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    Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
    81.
    发明申请
    Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists 审中-公开
    喹啉-4-甲酰胺衍生物作为nk-3和nk-2受体拮抗剂

    公开(公告)号：US20040152726A1

    公开(公告)日：2004-08-05

    申请号：US10474542

    申请日：2004-03-15

    发明人： Carlo Farina ,  Stefania Gagliardi ,  Giuseppe Arnaldo Maria Giardina ,  Marisa Martinelli

    IPC分类号： A61K031/47 ,  C07D215/38

    CPC分类号： C07D215/50 ,  C07D215/16 ,  C07D215/52 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D409/04 ,  C07D409/14 ,  C07D417/06 ,  C07D487/04

    摘要： A compound of formula (I) as detailed in the specification or a pharmaceutically acceptable salt or solvate thereof, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine. Figure (I) wherein: R1 is H or alkyl; R2 is aryl or cycloalkyl or heteroaryl; R3 is H or alkyl, wherein the group may be optionally substituted by one or more fluorine atoms; R4 is NR8R9; R8 is H, lakyl or R11R12 and R9 is H, alkyl or R13R14; or R8 and R9 together with the N atom to wich they are attached form a heterocyclic ring comprising 4-8 ring members, said ring members optionally including in addition to said N atom one or more further heteroatoms selected from N, O or S; and further detailed in the specification. 1

    摘要翻译： 说明书或其药学上可接受的盐或溶剂合物中详述的式（I）化合物，制备这些化合物的方法，包含这些化合物的药物组合物以及这些化合物在医药中的用途。 图（I）其中：R1是H或烷基; R2是芳基或环烷基或杂芳基; R3是H或烷基，其中基团可以任选被一个或多个氟原子取代; R4是NR8R9; R8是H，烷基或R11R12，R9是H，烷基或R13R14; 或R 8和R 9与它们所连接的N原子一起形成包含4-8个环成员的杂环，所述环成员除了所述N原子之外任选地还包括一个或多个另外的选自N，O或S的杂原子; 并在说明书中进一步详细描述。