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公开(公告)号：US12083124B2
公开(公告)日：2024-09-10
申请号：US18159798
申请日：2023-01-26
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Minh Nguyen , Chao Qi , Anlai Wang , Michael Witten , Yao Xu , Hai Fen Ye , Ke Zhang , Peng Zhao , Wenqing Yao
IPC分类号： A61K31/5377 , A61K31/437 , A61K31/496 , A61K31/4995 , A61P35/00 , C07D471/04 , C07D519/00
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/496 , A61K31/4995 , A61P35/00 , C07D471/04 , C07D519/00
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US12077539B2
公开(公告)日：2024-09-03
申请号：US17700923
申请日：2022-03-22
申请人： Incyte Corporation
发明人： Chao Qi , Xiaozhao Wang , Wenqing Yao
IPC分类号： C07D471/14 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/14 , A61P35/00
摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
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公开(公告)号：US12030889B2
公开(公告)日：2024-07-09
申请号：US17836602
申请日：2022-06-09
申请人： Incyte Corporation
发明人： Jun Pan , Jeremy Roach , Song Mei , Chunhong He , Liangxing Wu , Wenqing Yao
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519
CPC分类号： C07D487/04 , C07D519/00 , A61K31/519
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.
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公开(公告)号：US20240174664A1
公开(公告)日：2024-05-30
申请号：US18386224
申请日：2023-11-01
申请人： Incyte Corporation
发明人： Yingda Ye , Zhenwu Li , Ding-Quan Qian , Sarah Winterton , Kaijiong Xiao , Liangxing Wu , Wenqing Yao , Joshua Hummel , Meizhong Xu , Min Ye , Yingnan Chen , Margaret Favata , Yvonne Lo
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D519/00
摘要： The present application provides bicyclic amines that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
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公开(公告)号：US20240083918A1
公开(公告)日：2024-03-14
申请号：US18385742
申请日：2023-10-31
申请人： Incyte Corporation
发明人： Jun Pan , Yu Bai , Liangxing Wu , Wenqing Yao
IPC分类号： C07D519/00 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.
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公开(公告)号：US11912722B2
公开(公告)日：2024-02-27
申请号：US17307450
申请日：2021-05-04
申请人： Incyte Corporation
发明人： Liangxing Wu , Yingda Ye , Wenqing Yao
IPC分类号： C07D519/00 , A61K31/519 , A61P35/00 , A61K45/06
CPC分类号： C07D519/00 , A61K45/06
摘要： The present application provides tricyclic heteroaryl compounds that activate the STING pathway to produce interferons, which are useful in the treatment of various diseases including infectious diseases and cancer.
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公开(公告)号：US11891388B2
公开(公告)日：2024-02-06
申请号：US17558824
申请日：2021-12-22
申请人： Incyte Corporation
发明人： Kai Liu , Jun Pan , Alexander Sokolsky , Oleg Vechorkin , Hai Fen Ye , Qinda Ye , Wenqing Yao
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US11866426B2
公开(公告)日：2024-01-09
申请号：US17098880
申请日：2020-11-16
申请人： Incyte Corporation
发明人： Joshua Hummel , Oleg Vechorkin , Alexander Sokolsky , Qinda Ye , Kai Liu , Wenqing Yao
IPC分类号： C07D417/14 , A61P35/00 , C07D487/08 , C07D498/08
CPC分类号： C07D417/14 , A61P35/00 , C07D487/08 , C07D498/08
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US11851426B2
公开(公告)日：2023-12-26
申请号：US17067203
申请日：2020-10-09
申请人： Incyte Corporation
发明人： Yingda Ye , Zhenwu Li , Ding-Quan Qian , Sarah Winterton , Liangxing Wu , Wenqing Yao
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61P35/00
CPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D519/00
摘要： The present application provides bicyclic amines that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
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公开(公告)号：US11767323B2
公开(公告)日：2023-09-26
申请号：US17365686
申请日：2021-07-01
申请人： Incyte Corporation
发明人： Kai Liu , Onur Atasoylu , Yu Bai , Andrew W. Buesking , Leah C. Konkol , Cheng-Tsung Lai , Song Mei , Jun Pan , Liangxing Wu , Wenqing Yao
IPC分类号： C07D471/14 , A61K31/437 , C07D519/00
CPC分类号： C07D471/14 , C07D519/00
摘要： The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
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