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117 条记录 (耗时 0.021 秒)

    2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF
    71.
    发明申请
    2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF 审中-公开
    2-氨基-6-环丙氨基-3-（吡啶-4-基）咪唑并[1,2-B] - 吡啶衍生物，其制备方法及其治疗应用

    公开(公告)号：US20110312934A1

    公开(公告)日：2011-12-22

    申请号：US13058665

    申请日：2009-08-12

    申请人： Antonio Almario Garcia ,  Philippe Burnier ,  Sylvain Cote-Des Combes ,  Jean-François Gibert ,  Christophe Pacaud ,  Frédéric Puech ,  Yulin Chiang ,  Larry Davis ,  Zhongli Gao ,  Qiuxia Zhao

    发明人： Antonio Almario Garcia ,  Philippe Burnier ,  Sylvain Cote-Des Combes ,  Jean-François Gibert ,  Christophe Pacaud ,  Frédéric Puech ,  Yulin Chiang ,  Larry Davis ,  Zhongli Gao ,  Qiuxia Zhao

    IPC分类号： A61K31/551 ,  C07D498/10 ,  C07D471/08 ,  A61P25/30 ,  A61K31/5386 ,  A61P35/00 ,  A61P25/00 ,  C07D487/04 ,  A61K31/5025

    CPC分类号： C07D487/04 ,  C07D519/00

    摘要： The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy-C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl>C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, —NR4R5, hydroxyl or C1-4 alkyloxy groups; A is a C1-7-alkylene group optionally substituted by one or two Ra groups; B is a C1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1-6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-allyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.

    摘要翻译： 本发明涉及通式（I）的2-烷基-6-环氨基-3-（吡啶-4-基）咪唑并[1,2-b]哒嗪衍生物，其中：R2是C1-6烷基，C3 7-环烷基，C 3-7 - 环烷基-C 1-4 - 烷基，C 1-4 - 烷氧基-C1-烷基，C 3-7 - 环烷氧基-C 1-4 - 烷基，C 3-7 - 环烷基-C 1-4 - 烷氧基 C 1-4烷基，羟基-C 1-6 - 烷基，C 1-4 - 氟代烷基; R3是氢原子或选自卤素原子和C1-3烷基，-NR4R5，羟基或C1-4烷氧基的取代基; A是任选被一个或两个R a基团取代的C 1-7 - 亚烷基; B是任选被一个或两个Rb基团取代的C 1-7 - 亚烷基; L是任选被Rc或Rd基团取代的氮原子或被Re 1基团和Rd基团取代的碳原子或两个Re 2基团; Rd是选自氢原子或C 1-6 - 烷基，C 3-7 - 环烷基，C 3-7 - 环烷基-C 1-6 - 烷基，C 1-6 - 烷硫基-C 1-6 - 烷基，C 1-6 - 烷氧基-C 1-6 - 烷基，C 1-6 - 氟代烷基，羟基-C 1-6 - 烷基; R f是C 1-6 - 烷基，C 3-7 - 环烷基，C 3-7 - 环烷基-C 1-6 - 烷基，C 1-6 - 烷氧基-C 1-6 - 烷基，C 3-7 - 环烷氧基-C 1-4 - 烷基 C 3-7 - 环烷基-C 1-4 - 烷氧基-C 1-4 - 烷基，羟基-C 1-6 - 烯丙基，C 1-6 - 氟烷基或苄基。 本发明还涉及其制备方法及其治疗应用。

    Tower crane device
    73.
    发明授权
    Tower crane device 失效

    公开(公告)号：US07147117B2

    公开(公告)日：2006-12-12

    申请号：US10309586

    申请日：2002-12-04

    申请人： Larry Davis ,  Larry Howard ,  Michael Schiavoni

    发明人： Larry Davis ,  Larry Howard ,  Michael Schiavoni

    IPC分类号： B66C23/30

    CPC分类号： B66C23/32

    摘要： A crane tower device includes a basket that supports a tower crane and sits within a bay formed by the vertical columns of a building under construction. The basket and the tower crane are supported by support stubs that are attached to the vertical columns. Because the lateral and vertical load is principally distributed vertically to the vertical columns rather than horizontally, no reinforcement of the horizontal beams, floors or any other portion of the building structure are needed, which results in substantial cost savings.

    System and method for fast illumination-invariant background subtraction using two views
    74.
    发明申请
    System and method for fast illumination-invariant background subtraction using two views 有权

    公开(公告)号：US20060204077A1

    公开(公告)日：2006-09-14

    申请号：US11282513

    申请日：2005-11-18

    申请人： Ser-Nam Lim ,  Anurag Mittal ,  Larry Davis

    发明人： Ser-Nam Lim ,  Anurag Mittal ,  Larry Davis

    IPC分类号： H04N13/00 ,  G06K9/00 ,  G06T15/00

    CPC分类号： G06K9/00771 ,  G06T7/254 ,  G06T7/97

    摘要： A method for eliminating errors in foreground object detection in digitized images comprises providing a reference camera and a secondary camera, vertically aligning each said camera with a baseline that is approximately perpendicular to a ground plane, wherein said reference camera is placed lower than said secondary camera, selecting a foreground pixel in a reference view of a first point in a foreground object, finding a conjugate pixel of the foreground pixel in a secondary view, using the foreground and conjugate pixels to determine an image base pixel of a base point in the reference view, wherein said base point is a point on the ground plane below the first point, and using the foreground and image base pixels to find a location where the ground plane is first visible.

    Weight-balanced golf putter head
    75.
    发明申请
    Weight-balanced golf putter head 失效
    重量平衡高尔夫推杆头

    公开(公告)号：US20050282656A1

    公开(公告)日：2005-12-22

    申请号：US11136294

    申请日：2005-05-23

    申请人： Larry Davis

    发明人： Larry Davis

    IPC分类号： A63B53/04 ,  A63B59/00

    CPC分类号： A63B53/0487 ,  A63B60/42 ,  A63B2053/0441 ,  A63B2053/0491 ,  A63B2209/00

    摘要： A golf putter head is generally triangular, when viewed from the top, with a flat, front face and a trailing, central tail. When viewed from the side, the head has a generally straight front face and a flat or slightly curved or rounded bottom surface. The shaft for the grip is anchored to the head at a generally central position on the top of the head, with the axis of the shaft from the ball contact point on the face of the putter head being about one-half the diameter of a legal U.S. golf ball. The head is formed and/or weighted so that the shaft is on the horizontal center of gravity of the putter head, and the vertical center of gravity is about midway between the top and bottom surfaces of the head.

    摘要翻译： 当从顶部观察时，高尔夫球杆头通常是三角形的，具有平坦的前表面和后尾中央尾部。 当从侧面观察时，头部具有大致直的前表面和平坦或略微弯曲或圆形的底部表面。 用于把手的轴在头部的顶部的大致中心位置处固定到头部，轴的从推杆头的表面上的球接触点的轴线约为法定直径的一半 美国高尔夫球 头部被形成和/或加权，使得轴处于推杆头的水平重心上，并且垂直重心位于头部的顶表面和底表面之间的大约中间。

    N-substituted-4-pyrimidinamines and pyrimidinediamines
    78.
    发明授权
    N-substituted-4-pyrimidinamines and pyrimidinediamines 失效
    N-取代-4-嘧啶胺和嘧啶二胺

    公开(公告)号：US5179204A

    公开(公告)日：1993-01-12

    申请号：US584554

    申请日：1990-09-18

    申请人： Richard C. Effland ,  Joseph T. Klein ,  Larry Davis ,  Gordon E. Olsen

    发明人： Richard C. Effland ,  Joseph T. Klein ,  Larry Davis ,  Gordon E. Olsen

    IPC分类号： C07D403/12 ,  C07D403/14

    CPC分类号： C07D403/12 ,  C07D403/14

    摘要： This invention relates to N-heteroaryl-4-pyrimidinamines of the formula ##STR1## where R.sub.1 is hydrogen, loweralkyl, aryl, or arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen or loweralkyl, or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen or loweralkyl, or R.sub.4 and R.sub.5 taken together are aryl; X is hydrogen, halogen, cyano, nitro, amino, loweralkyl, loweralkoxy, trifluoromethyl or ##STR2## where Y is hydrogen, halogen or loweralkyl; m is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometrical and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as memory enhancing agents and as analgesic agents.

    摘要翻译： 本发明涉及式（I）的N-杂芳基-4-嘧啶胺，其中R 1是氢，低级烷基，芳基或芳基低级烷基; R2和R3独立地是氢或低级烷基，或R2和R3一起是芳基; R4和R5独立地是氢或低级烷基，或R4和R5一起是芳基; X是氢，卤素，氰基，硝基，氨基，低级烷基，低级烷氧基，三氟甲基或者其中Y是氢，卤素或低级烷基; m为1〜3的整数。 和其药学上可接受的酸加成盐，并且在适用的情况下，其几何和旋光异构体及其外消旋混合物。 本发明的化合物显示效用作为记忆增强剂和止痛剂。

    1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation
    79.
    发明授权
    1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation 失效
    1-芳氧基-2,3,4,5-四氢-3-苯并氮杂制剂

    公开(公告)号：US5059688A

    公开(公告)日：1991-10-22

    申请号：US513400

    申请日：1990-04-23

    申请人： Richard C. Effland ,  Joseph T. Klein ,  Larry Davis

    发明人： Richard C. Effland ,  Joseph T. Klein ,  Larry Davis

    IPC分类号： C07D223/16

    CPC分类号： C07D223/16

    摘要： The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, No.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen CF.sub.3, NO.sub.2 and NH.sub.2 ; Aryloxy lower alkyl of the formula ##STR4## where Z is as previously defined; and an alkylene amine of the formula ##STR5## where R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl, n is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof.

    摘要翻译： 本发明涉及式（I）的1-芳氧基-2,3,4,5-四氢-3-苯并吖庚因，其中Y相同或不同，为氢和低级烷氧基; X是氢，卤素，低级烷基，低级烷氧基，CF 3，NO 2，CN和NH 2; R是氢，低级烷基，环烷基低级烷基，其中Z是氢，低级烷基，低级烷氧基，卤素，CF 3，NO 2和NH 2; 其中Z如前所定义的式“IMAGE”的芳氧基低级烷基; 和式“IMAGE”的亚烷基胺，其中R 1和R 2相同或不同，为氢和低级烷基，n为1或2的整数; 及其药学上可接受的酸加成盐。