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公开(公告)号：US20220031811A1
公开(公告)日：2022-02-03
申请号：US17306184
申请日：2021-05-03
摘要： The present invention refers to a pharmaceutical composition comprising (a) lixisenatide or/and a pharmaceutically acceptable salt thereof, and (b) insulin glargine or/and a pharmaceutically acceptable salt thereof, wherein the compound (b) and compound (a) are present in a fixed ratio.
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公开(公告)号：US20220023543A1
公开(公告)日：2022-01-27
申请号：US17449577
申请日：2021-09-30
发明人： Thomas Mark Kemp , Hugo Revellat
摘要： The present disclosure relates to a drug delivery device having a case adapted to retain a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, and at least one feedback mechanism that is in operative connection with the plunger. The feedback mechanism includes a collar, a needle shroud, and a control spring biasing the needle shroud in a distal direction relative to the collar. The collar is operatively coupled to the case in an axial direction and prevented from axially decoupling from the case by the plunger when in the proximal position. The plunger, during movement from the proximal position towards the distal position, allows axial decoupling of the collar from the case driven by the control spring until the collar's movement is halted, which creates an audible and/or tactile feedback.
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公开(公告)号：US20220016358A1
公开(公告)日：2022-01-20
申请号：US17391193
申请日：2021-08-02
发明人： Thomas Mark Kemp , Carsten Mosebach
摘要： The disclosure further relates to an autoinjector and a method of assembling the autoinjector. A syringe carrier is disclosed comprising a housing adapted to receive a syringe. They syringe includes a needle encapsulated by a removable protective needle sheath. The syringe carrier further includes two or more flexible arms protruding outwards in a relaxed state and adapted to couple with the syringe in a mounted position. In the mounted position, the flexible arms deflect radially inwards due, in part, to an axial force operating on the syringe carrier.
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公开(公告)号：US20220016217A1
公开(公告)日：2022-01-20
申请号：US17237632
申请日：2021-04-22
发明人： Ulrich Werner , Barbel Rotthauser
摘要： The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.
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公开(公告)号：US11213628B2
公开(公告)日：2022-01-04
申请号：US14771544
申请日：2014-03-10
IPC分类号： A61M5/315
摘要： The bearing component comprises a contact surface inside a periphery, which surrounds a centre, and a coupling feature arranged inside the periphery for rotatably engaging a component of a piston rod perpendicular to the contact surface. The coupling feature includes at least one flexible feature extending from the periphery towards the centre, and the flexible feature is arranged to be deflected towards the periphery by a force exerted on the flexible feature in a direction towards the contact surface and deflected towards the centre by a force exerted on the flexible feature in the opposite direction. The flexible feature may have a sloping surface facilitating assembly and preventing disassembly in combination with a further component of the piston rod. The component of the piston rod may be a lead screw, and the piston rod may be used in a drug delivery device.
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公开(公告)号：US11213627B2
公开(公告)日：2022-01-04
申请号：US15778278
申请日：2016-11-21
发明人： Marc Schader , Michael Helmer , Peter Nober , Michael Varga
摘要： A medicament injection device comprising a main body arranged to receive a medicament cartridge; a needle carrier carrying a needle, wherein the needle carrier is axially movable with respect to the main body; and a rotatable cap at a distal end of the device, wherein the cap is removably coupled to the needle carrier, a releasable arrangement between the main body and the cap comprising a guide element and a slotted link, wherein the slotted link is arranged to cause the guide element to follow a predefined path at least partly in an axial direction during rotational movement of the cap, thereby causing the needle carrier to move axially towards a proximal end of the device as the cap is rotated up to a predefined point, wherein the main body comprises a medicament cartridge holder comprising the guide element depending therefrom for engagement with the cap.
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公开(公告)号：US20210393891A1
公开(公告)日：2021-12-23
申请号：US17146948
申请日：2021-01-12
摘要： A method and system for detecting a limit of use of a medical device is disclosed. The method includes starting a timer of a medical device when said medical device is used for the first time, detecting the limit of use of the medical device and indicating the limit of use of the medical device. The limit of use is reached when at least one of a first criterion and a second criterion is met, wherein the first criterion is that the timer reaches or exceeds a time limit and wherein the second criterion is that at least one operation of a drive train of said medical device reaches or exceeds a limit.
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公开(公告)号：US20210393884A1
公开(公告)日：2021-12-23
申请号：US17466127
申请日：2021-09-03
发明人： Masaru Saiki
IPC分类号： A61M5/315
摘要： A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.
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公开(公告)号：US11197963B2
公开(公告)日：2021-12-14
申请号：US15761731
申请日：2016-09-20
发明人： Michael Helmer , Stefan Wendland
摘要： A supplementary device is configured to be attached to a drug delivery device. The supplementary device comprises a non-contact sensor configured to output signals indicative of the position of a moveable component within the drug delivery device. The supplementary device further comprises a processor configured to receive the signals output from the non-contact sensor. This processor is additionally configured to determine, based on the signals, whether the drug delivery device is in a pre-activation state or a post-activation state.
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公开(公告)号：US11197959B2
公开(公告)日：2021-12-14
申请号：US17321147
申请日：2021-05-14
摘要： A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
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