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159 条记录 (耗时 0.04 秒)

    Process for making a crystalline zilpaterol salt
    74.
    发明授权
    Process for making a crystalline zilpaterol salt 有权
    制备结晶齐帕特罗盐的方法

    公开(公告)号：US08343956B2

    公开(公告)日：2013-01-01

    申请号：US13039455

    申请日：2011-03-03

    申请人： Oliver Krebs ,  Philipp Kuenti ,  Christoph Michlig ,  Karl Reuter

    发明人： Oliver Krebs ,  Philipp Kuenti ,  Christoph Michlig ,  Karl Reuter

    IPC分类号： A61K31/55 ,  C07D487/06

    CPC分类号： C07D487/06

    摘要： This invention generally relates to processes for making a crystalline zilpaterol salt, particularly zilpaterol hydrochloride. This invention also relates to methods of treatment using a crystalline zilpaterol salt prepared in accordance with this invention to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.

    摘要翻译： 本发明一般涉及制备结晶齐帕特罗盐，特别是盐酸齐帕特罗的方法。 本发明还涉及使用根据本发明制备的结晶齐帕特罗盐治疗以增加家畜，家禽和鱼类中的体重增加速率，提高饲料效率和/或增加胴体瘦肉的方法。

    Zilpaterol enantiomer compositions and methods of making and using such compositions
    75.
    发明授权
    Zilpaterol enantiomer compositions and methods of making and using such compositions 有权
    齐帕特罗对映异构体组合物和制备和使用这些组合物的方法

    公开(公告)号：US08268813B2

    公开(公告)日：2012-09-18

    申请号：US12373221

    申请日：2007-07-10

    申请人： Christian Miculka ,  Thorsten Meyer ,  Christopher Kern ,  Serge Francois Droux

    发明人： Christian Miculka ,  Thorsten Meyer ,  Christopher Kern ,  Serge Francois Droux

    IPC分类号： A61P1/16 ,  A61K31/551 ,  A23K1/16 ,  C07D487/06

    CPC分类号： C07D487/06 ,  A23K20/137 ,  A23K50/10

    摘要： This invention is directed generally to zilpaterol enantiomer compositions, and, in particular, to compositions comprising the 6R,7R zilpaterol enantiomer. This invention is also directed to processes for making such compositions; methods for using such compositions to, for example, increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and/or fish; and uses of such compositions to make medicaments. This invention is further directed to methods for determining the absolute configurations of zilpaterol enantiomers.

    摘要翻译： 本发明一般涉及齐伐他醇对映异构体组合物，尤其涉及包含6R，7R齐伐他醇对映异构体的组合物。 本发明还涉及制备这种组合物的方法; 使用这种组合物的方法例如可以增加家畜，家禽和/或鱼中的体重增加率，提高饲料效率和/或增加胴体瘦身; 以及这些组合物的用途来制备药物。 本发明进一步涉及确定齐勒特罗对映异构体的绝对构型的方法。

    MACROLIDE SYNTHESIS PROCESS AND SOLID-STATE FORMS
    76.
    发明申请
    MACROLIDE SYNTHESIS PROCESS AND SOLID-STATE FORMS 有权
    MACROLIDE合成方法和固体形式

    公开(公告)号：US20120208779A1

    公开(公告)日：2012-08-16

    申请号：US13401991

    申请日：2012-02-22

    申请人： Fritz Blatter ,  Timo Rager ,  Ralf Warras

    发明人： Fritz Blatter ,  Timo Rager ,  Ralf Warras

    IPC分类号： A61K31/7048 ,  A61P31/04 ,  A61P11/00

    CPC分类号： C07H17/08

    摘要： Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.

    摘要翻译： 描述了制备大环内酯类的方法，特别是制备任选取代的20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯及其衍生物的方法，以及大环内酯类制备药物的用途，使用大环内酯类的治疗方法 ，以及制备中间体的方法，其特别可用于制备大环内酯。 还描述了20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯的溶剂化和非溶剂化结晶形式，以及制备这种结晶形式的方法，包含（或衍生自）这种结晶形式的药物，制备药物的方法 包括（或衍生自）这种结晶形式，使用这种结晶形式的处理方法，以及包含这种结晶形式的试剂盒。

    Macrolide synthesis process and solid-state forms
    77.
    发明授权
    Macrolide synthesis process and solid-state forms 有权

    公开(公告)号：US08227429B2

    公开(公告)日：2012-07-24

    申请号：US11828404

    申请日：2007-07-26

    申请人： Ralf Warrass ,  Fritz Blatter ,  Meinrad Brenner ,  Guixan Hu ,  Tamo Rager

    发明人： Ralf Warrass ,  Fritz Blatter ,  Meinrad Brenner ,  Guixan Hu ,  Tamo Rager

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.

    MACROLIDE SYNTHESIS PROCESS AND SOLID-STATE FORMS
    78.
    发明申请
    MACROLIDE SYNTHESIS PROCESS AND SOLID-STATE FORMS 有权
    MACROLIDE合成方法和固体形式

    公开(公告)号：US20120122808A1

    公开(公告)日：2012-05-17

    申请号：US13359327

    申请日：2012-01-26

    申请人： Ralf Warrass ,  Fritz Blatter ,  Meinrad Brenner ,  Guixan Hu ,  Timo Rager

    发明人： Ralf Warrass ,  Fritz Blatter ,  Meinrad Brenner ,  Guixan Hu ,  Timo Rager

    IPC分类号： A61K31/706 ,  A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, among other uses, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.

    摘要翻译： 描述了制备大环内酯类的方法，特别是制备任选取代的20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯及其衍生物的方法，以及大环内酯类制备药物的用途，使用大环内酯类的治疗方法 以及用于制造中间体的方法，除了其它用途之外，可以使用它们来制备大环内酯类。 还描述了20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯的溶剂化和非溶剂化结晶形式，以及制备这种结晶形式的方法，包含（或衍生自）这种结晶形式的药物，制备药物的方法 包括（或衍生自）这种结晶形式，使用这种结晶形式的处理方法，以及包含这种结晶形式的试剂盒。

    Refrigerator for storing vials and cartridge for use in the same
    80.
    发明授权
    Refrigerator for storing vials and cartridge for use in the same 有权
    冰箱用于储存用于相同的小瓶和墨盒

    公开(公告)号：US08156755B2

    公开(公告)日：2012-04-17

    申请号：US11144955

    申请日：2005-06-03

    申请人： Stephen Murray ,  Gaynor Hillier ,  Philip Nigel Bordet-Stead ,  Tanja Langgner ,  David Helps

    发明人： Stephen Murray ,  Gaynor Hillier ,  Philip Nigel Bordet-Stead ,  Tanja Langgner ,  David Helps

    IPC分类号： F25D25/00

    CPC分类号： F25B21/02 ,  F25D25/00 ,  F25D31/007 ,  F25D2331/805 ,  F25D2400/10

    摘要： The invention relates to a refrigerator for storing vials containing a (bio)pharmaceutical substance, in particular vaccines for animals, comprising a cabinet having an internal space for accommodating the vials arranged in columns, a cooling element for cooling the internal space and at least one door or dispenser for removing vials from the internal space. A plurality of guides located inside the space and adapted to slidingly accommodate columns of the vials. The invention further relates to a cartridge suitable for use in the said refrigerator.

    摘要翻译： 本发明涉及一种用于储存含有（生物）药物物质的小瓶的冰箱，特别是用于动物的疫苗，该冰箱包括一个具有用于容纳设置成立柱的小瓶的内部空间的橱柜，用于冷却内部空间的冷却元件和至少一个 门或分配器，用于从内部空间移除小瓶。 多个引导件位于空间内并且适于滑动地容纳小瓶的柱。 本发明还涉及适用于所述冰箱的筒。