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公开(公告)号：US20070154906A1
公开(公告)日：2007-07-05
申请号：US11544191
申请日：2006-10-05
Applicant: Christopher Martin , Philip Howard , David Thurston , John Hartley , Francesca Crawford
Inventor： Christopher Martin , Philip Howard , David Thurston , John Hartley , Francesca Crawford
CPC classification number: A61K31/711 , G16B35/00 , G16C20/60
Abstract: The invention provides systematic methods for identification of candidate compounds useful in treatment of conditions initiated or modulated by genetic expression. The methods of the invention permit efficient identification of candidates suitable for verification testing by in vitro and/or in vivo models.
Abstract translation: 本发明提供了用于鉴定可用于治疗由遗传表达启动或调节的病症的候选化合物的系统方法。 本发明的方法允许通过体外和/或体内模型有效鉴定适合于验证测试的候选物。
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62.发明申请Raman signature probes and their use in the detection and imaging of molecular processes and structures 审中-公开拉曼标记探针及其在分子过程和结构检测和成像中的应用
公开(公告)号：US20070134733A1
公开(公告)日：2007-06-14
申请号：US10564110
申请日：2004-07-09
Applicant: Mustapha Haddach , Gregory S. Naeve
Inventor： Mustapha Haddach , Gregory S. Naeve
CPC classification number: G01N21/65 , G01N21/658 , G01N33/53 , G01N33/5308 , G01N2021/653 , G01N2021/656
Abstract: Disclosed are methods and materials for detecting and imaging molecular processes and structures. Methods included detecting and imaging by contacting targets with RSPs, irradiating the target, and collecting and analyzing the spectra produced by the RSPs.
Abstract translation: 公开了用于检测和成像分子过程和结构的方法和材料。 方法包括通过使目标与RSP接触进行检测和成像，照射靶标，以及收集和分析RSP产生的光谱。
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63.发明申请Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same 有权用于鉴定调节非翻译区域依赖性基因表达的化合物的方法及其使用方法
公开(公告)号：US20070111203A1
公开(公告)日：2007-05-17
申请号：US10543033
申请日：2004-01-21
Applicant: Liangxian Cao , Panayiota Trifillis
Inventor： Liangxian Cao , Panayiota Trifillis
CPC classification number: C12Q1/6897 , C07K14/52 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , G01N2333/515 , G01N2500/00
Abstract: The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
Abstract translation: 本发明涉及用于鉴定调节靶基因的非翻译区域依赖性表达的化合物的方法。 本发明特别涉及使用与报告基因连接的靶基因的非翻译区或其片段来鉴定调节靶基因的非翻译区域依赖性表达的化合物。 本发明的方法提供了用于识别药物引线的化合物文库的高通量筛选的简单，灵敏的测定。
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公开(公告)号：US20070087382A1
公开(公告)日：2007-04-19
申请号：US10571456
申请日：2004-09-10
Applicant: Stefan Howorka , Patrick Pammer
Inventor： Stefan Howorka , Patrick Pammer
CPC classification number: B82Y30/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00459 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , C40B40/06 , C40B40/10 , C40B60/14
Abstract: The invention relates to assemblies for bonding molecules comprising bondable functional groups, which are present on a solid supporting material as individual molecular functional groups or multiple identical functional groups. Said assemblies are characterised in that the density of the individual functional groups or multiple functional groups on the solid supporting material is between 104 and 1010 individual or multiple functional groups per cm2 and that there are no additional bondable functional groups within a selected distance d from any individual bondable functional group or multiple functional group for at least 95% and in particular at least 99% of the individual or multiple functional groups.
Abstract translation: 本发明涉及用于结合包含可结合官能团的分子的组合物，其作为单独的分子官能团或多个相同的官能团存在于固体支持材料上。 所述组件的特征在于，固体支持材料上的各个官能团或多个官能团的密度为每厘米10个至10个/个以上的单个或多个官能团 并且在单个或多个功能的至少95％，特别是至少99％的任何个别可结合官能团或多官能团的选定距离d内不存在额外的可结合的官能团 团体
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65.发明申请Compositions and methods for in vitro sorting of molecular and cellular libraries 审中-公开分子和细胞文库的体外分选的组合物和方法
公开(公告)号：US20070077572A1
公开(公告)日：2007-04-05
申请号：US11439533
申请日：2006-05-24
Applicant: Dan Tawfik , Kalia Bernath , Amir Aharoni , Sergio Peisajovich , Andrew Griffiths , Enrico Mastrobattista , Shlomo Magdassi
Inventor： Dan Tawfik , Kalia Bernath , Amir Aharoni , Sergio Peisajovich , Andrew Griffiths , Enrico Mastrobattista , Shlomo Magdassi
CPC classification number: C12N15/1075 , C40B40/08
Abstract: The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulsion includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.
Abstract translation: 本发明提供了用于分子或细胞文库区分的体外系统，并提供从文库中选择和分离所需分子或细胞的方法。 该文库包括多个不同的分子或包封在水包油包水乳液中的细胞。 乳液包括连续的外部水相和油包水液滴的不连续分散体。 多个这样的液滴的内部水相包含位于文库的多个不同分子或细胞内的特定分子或细胞。
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公开(公告)号：US20070059844A1
公开(公告)日：2007-03-15
申请号：US11162485
申请日：2005-09-12
Applicant: James HARPER , David TURNER , Kenneth JACOBSON , Brian WEST
Inventor： James HARPER , David TURNER , Kenneth JACOBSON , Brian WEST
Abstract: A pigment library and a method for preparing it are provided, which includes identifying a plurality of thermoplastic polymers and then selecting pigments useful in the plurality of thermoplastic polymers. The pigments are heat stable at the melt temperature of each of the plurality of thermoplastic polymers and are not chemically interactive or reactive with each of the polymers of the plurality of thermoplastic polymer. Further, each of the pigments in combination with each of the polymers of the plurality of thermoplastic polymers possesses the property of being lightfast, injection moldable, and fiber spinnable and also not crocking. A colorant database is then prepared using the pigment library. The colorant database is used with color matching software that predict formulations using the colorant database. The result is the development of formulations that minimize or eliminate metameric color effect under various lighting conditions across multiple polymers and end product types.
Abstract translation: 提供了颜料库及其制备方法，其包括鉴定多种热塑性聚合物，然后选择可用于多种热塑性聚合物的颜料。 颜料在多种热塑性聚合物的熔融温度下是热稳定的，并且与多种热塑性聚合物中的每一种聚合物不化学相互作用或具有反应性。 此外，与多种热塑性聚合物的每种聚合物组合的每种颜料都具有耐光性，可注射模塑性和可纺纤维性，并且也不会变质的性质。 然后使用颜料库制备着色剂数据库。 着色剂数据库与使用着色剂数据库预测配方的颜色匹配软件一起使用。 结果是开发了在多个聚合物和最终产品类型下在各种照明条件下最小化或消除同色异色效应的配方。
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公开(公告)号：US20070059769A1
公开(公告)日：2007-03-15
申请号：US11516014
申请日：2006-09-05
Applicant: Ola Blixt , Steve Head
Inventor： Ola Blixt , Steve Head
CPC classification number: G01N33/54386 , B01J2219/00387 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00731 , G01N2400/10
Abstract: The invention provides arrays of glycans for detecting entities that bind to glycans. In some embodiments, the arrays can be used to detect disease, blood types, antibodies, bacterial or viral infection, cancer, and the like. The invention also provides methods and kits for such detection. In another embodiment, the invention provides methods of preventing or treating disease in a mammal by administering to the mammal a composition that includes at least glycan.
Abstract translation: 本发明提供用于检测结合聚糖的实体的聚糖阵列。 在一些实施方案中，阵列可用于检测疾病，血型，抗体，细菌或病毒感染，癌症等。 本发明还提供了用于这种检测的方法和试剂盒。 在另一个实施方案中，本发明通过向哺乳动物施用至少包含聚糖的组合物来提供预防或治疗哺乳动物疾病的方法。
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68.发明申请Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure 失效磁性物质 - 生物体复合结构，能够与磁性物质连接的肽片段及其基因，以及复合结构体的制造方法
公开(公告)号：US20070054315A1
公开(公告)日：2007-03-08
申请号：US10546404
申请日：2004-04-30
Applicant: Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
Inventor： Takeshi Imamura , Tetsuya Yano , Tsuyoshi Nomoto , Shinya Kozaki , Tsutomu Honma , Akiko Tsuchitani
CPC classification number: C12N9/1025 , C07K2319/00 , C12N11/06 , C12N11/14 , C12N15/1013 , G01N33/54326 , G01N33/54353 , Y10S530/811
Abstract: A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.
Abstract translation: 磁性物质 - 生物物质复合结构包括含磁性物质的载体和固定在载体上的生物物质，生物质通过载体表面上的氨基酸序列的间隔物固定化。
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69.发明申请Method for selectively binding a substrate to sorbents by way of at least bivalent bonds 审中-公开通过至少二价键选择性地将底物与吸附剂结合的方法
公开(公告)号：US20060292569A1
公开(公告)日：2006-12-28
申请号：US10550756
申请日：2004-03-24
Applicant: Klaus Gottschall
Inventor： Klaus Gottschall
CPC classification number: B01J20/3253 , B01J20/3242 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3285 , G01N33/543
Abstract: A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii): (i) determining at least two groups capable of binding a sorbent from a synthetic or natural first substrate, (ii) respectivly applying at least two different groups capable of binding a second synthetic or natural substrate to one respective carrier, thereby forming at least one sorbent, whereby the groups are the same groups of step (i) or are groups that are complementary thereto, and the second substrate of step (ii) is the same or different from the first substrate according to step (i), and whereby the groups are determined such that the contributions of the Gibbs energies of the individual groups to the non-covalent bond with the second substrate yield a negative value of the Gibbs energy ΔG, such that a binding strengthening occurs that results in an improved separation selectivity with respect to at least one substance to be separated off.
Abstract translation: 一种用于制造具有至少两个能够结合底物的选择性结合的至少两个不同基团的吸附剂的方法，其特征在于其包括步骤（i）至（ii）：（i）确定 至少两个能够从合成或天然的第一底物粘合吸附剂的基团，（ii）相对于至少两个能够将第二合成或天然底物结合到一个相应载体上的不同基团，从而形成至少一种吸附剂，由此， 基团是步骤（i）的相同组或与其互补的基团，并且步骤（ii）的第二底物与根据步骤（i）的第一底物相同或不同，并且由此确定这些基团 单个组的吉布斯能量对与第二底物的非共价键的贡献产生吉布斯能量DeltaG的负值，使得发生结合强化，导致改进 相对于待分离的至少一种物质的分离选择性。
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公开(公告)号：US20050142614A1
公开(公告)日：2005-06-30
申请号：US11054754
申请日：2005-02-09
Applicant: Jim Wells , Dan Erlanson , Andrew Braisted
Inventor： Jim Wells , Dan Erlanson , Andrew Braisted
IPC: G01N33/531 , C07B61/00 , C07C323/39 , C07C335/04 , C07D207/46 , C07D333/38 , C07D333/70 , C07D401/04 , C07D405/12 , C07K14/00 , C07K14/435 , C12Q1/00 , C12Q1/68 , C12Q1/70 , C40B20/08 , C40B30/04 , C40B40/04 , G01N33/00 , G01N33/53
CPC classification number: C40B40/04 , C07D207/46 , C07D333/38 , C07D333/70 , C07D401/04 , C07D405/12 , C40B20/08 , C40B30/04 , G01N33/6845
Abstract: The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed “tethering” where potential ligands are covalently bonded or “tethered” to a target and subsequently identified.
Abstract translation: 本发明提供了配体发现的新方法。 本发明的方法依赖于称为“系链”的过程，其中潜在的配体共价键合或“连接”到靶并随后鉴定。
