公开(公告)号：US20220259218A1

公开(公告)日：2022-08-18

申请号：US17585530

申请日：2022-01-26

申请人： SITEONE THERAPEUTICS, INC. ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： John Mulcahy ,  Hassan Pajouhesh ,  George Miljanich ,  Anton Delwig ,  Jacob Beckley ,  Grant Masaaki Shibuya ,  Justin Du Bois

IPC分类号： C07D487/14

摘要： Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.

公开(公告)号：US11414425B2

公开(公告)日：2022-08-16

申请号：US16445854

申请日：2019-06-19

申请人： AGENEBIO, INC.

发明人： Belew Mekonnen ,  John A. Butera ,  Jianxing Huang ,  Hemantbhai Patel ,  Qin Jiang ,  Robert Jason Herr ,  Emily Elizabeth Freeman ,  Nicholas James Mayhew

IPC分类号： A61K31/551 ,  A61K31/5517 ,  A61K45/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D487/12 ,  C07D487/14

摘要： This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an α5-containing GABAA receptor agonist (e.g., an α5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease (AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an α5-containing GABAA receptor agonist (e.g., an α5-containing GABAA receptor positive allosteric modulator) in treating brain cancers (including brain tumors, e.g., medulloblastomas), and cognitive impairment associated therewith.

公开(公告)号：US20220177478A1

公开(公告)日：2022-06-09

申请号：US17440504

申请日：2020-03-17

申请人： Merck Patent GmbH

发明人： Amir Hossain PARHAM ,  Jonas Valentin KROEBER ,  Jens ENGELHART ,  Anja JATSCH ,  Christian EICKHOFF ,  Christian EHRENREICH

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D487/14 ,  C07D513/14 ,  C07F9/02 ,  H01L51/00 ,  C07F5/02

摘要： The invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.

公开(公告)号：US20220125785A1

公开(公告)日：2022-04-28

申请号：US17506220

申请日：2021-10-20

申请人： HUTCHISON MEDIPHARMA LIMITED

发明人： Guangxiu DAI ,  Kun XIAO

IPC分类号： A61K31/4985 ,  A61K45/06 ,  A61P35/00 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/53

摘要： The present invention belongs to the pharmaceutical field, and provides crystalline forms, solvates and the crystalline forms thereof of the compound (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbo nitrile, and the pharmaceutical compositions comprising the same as well as the methods of preparing the same and the use thereof.

公开(公告)号：US20220089604A1

公开(公告)日：2022-03-24

申请号：US17447685

申请日：2021-09-14

申请人： Samsung Display Co., Ltd.

发明人： Junwoo Park

IPC分类号： C07D487/14 ,  H01L51/00

摘要： Provided are a heterocyclic compound represented by Formula 1, a hole transport composition containing the same, a light-emitting device including the hole transport composition, a method of manufacturing the light-emitting device, and an electronic apparatus including the light-emitting device, wherein each substituent in Formula 1 is the same as described in the present specification.

公开(公告)号：US11279706B2

公开(公告)日：2022-03-22

申请号：US16499201

申请日：2018-03-29

申请人： SITEONE THERAPEUTICS, INC. ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： John Mulcahy ,  Hassan Pajouhesh ,  George Miljanich ,  Anton Delwig ,  Jacob Beckley ,  Grant Masaaki Shibuya ,  Justin Du Bois

IPC分类号： C07D487/14 ,  A61P29/00

摘要： Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R1, X1, and X2 are as described herein.

公开(公告)号：US20220085296A1

公开(公告)日：2022-03-17

申请号：US17455764

申请日：2021-11-19

申请人： DUK SAN NEOLUX CO., LTD.

发明人： Yun Suk LEE ,  Min Ji JO ,  Jung Hwan PARK ,  Bum Sung LEE

IPC分类号： H01L51/00 ,  C07D405/04 ,  C07D409/14 ,  C07D405/14 ,  C07D409/10 ,  C07D487/04 ,  C07D495/04 ,  C07D487/14

摘要： Provided are a compound of Formula 2-K, an organic electric element including a first electrode, a second electrode, and an organic material layer formed between the first electrode and the second electrode, and an electronic device thereof, including the compound of Formula 2-K in the organic material layer, and thereby achieving lowered driving voltage, improved luminous efficiency, and extended life time.

公开(公告)号：US11261193B2

公开(公告)日：2022-03-01

申请号：US16721631

申请日：2019-12-19

申请人： G1 Therapeutics, Inc.

发明人： Alexander Smith ,  Hannah S. White ,  Patricia Andres ,  Xufeng Sun ,  Lei Zhu ,  Petinka I. Vlahova

IPC分类号： C07D487/14 ,  A61K45/06

摘要： This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of for advantageous therapeutic pharmaceutical efficacy and dosage form stability.

公开(公告)号：US11242351B2

公开(公告)日：2022-02-08

申请号：US16955975

申请日：2018-12-21

申请人： Ontario Institute for Cancer Research (OICR)

发明人： Rima Al-awar ,  Methvin Isaac ,  Anh My Chau ,  Ahmed Mamai ,  Iain Watson ,  Gennady Poda ,  Pandiaraju Subramanian ,  Brian Wilson ,  David Uehling

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07D487/14 ,  A61P35/04 ,  C07D471/14 ,  C07D498/14 ,  C07D519/00

摘要： The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

公开(公告)号：US20220024940A1

公开(公告)日：2022-01-27

申请号：US17496939

申请日：2021-10-08

申请人： MERCK & CIE

发明人： Rudolf MOSER ,  Viola GROEHN ,  Thomas EGGER ,  Thomas AMMANN

IPC分类号： C07D487/14 ,  C07D475/04

摘要： The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.