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51.发明授权Biological adhesive composition and method of promoting adhesion between tissue surfaces 失效生物粘合剂组合物和促进组织表面之间粘附的方法公开(公告)号：US5549904A
公开(公告)日：1996-08-27
申请号：US071528
申请日：1993-06-03
Applicant: Kay Juergensen , Daniel Aeschlimann , Ernst B. Hunziker
Inventor： Kay Juergensen , Daniel Aeschlimann , Ernst B. Hunziker
CPC classification number: C12N9/1044 , A61K38/45 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/102 , A61L2300/254 , A61L2300/414 , Y10S514/953 , Y10S514/955 , Y10S514/965 , Y10S530/835 , Y10S530/84 , Y10S530/841 , Y10S530/842 , Y10S530/846 , Y10S530/85
Abstract: A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
Abstract translation: 配制的生物粘合剂组合物在药学上可接受的水性载体中使用组织转谷氨酰胺酶。 组织转谷氨酰胺酶以有效的催化量使用，以通过催化组织和/或酶的谷氨酰胺残基和胺供体之间的反应来促进组织表面之间的粘附。 载体包含二价金属离子如钙，以促进所述反应。
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公开(公告)号：US20240226369A1
公开(公告)日：2024-07-11
申请号：US18559199
申请日：2022-05-06
Applicant: LABORATORIOS INIBSA, S.A.
Inventor： Joaquín Nebot Troyano , Ramon M. Roca I Juanes
CPC classification number: A61L24/0015 , A61L24/046 , A61L24/10 , C08L33/10 , A61L2300/214 , A61L2300/404 , A61L2300/80 , A61L2400/14 , C08L2203/02
Abstract: A composition including: (a) one or more alkyl acrylaor alkyl methacrylate based polymer film forming agents; (b) one or more (C1-C6)alkyl N(alpha)-(C10-C25)alkanoyl-L-arginate disinfectant or a salt thereof; (c) a solvent system comprising: (c1) one or more water immiscible solvents selected from (C1-C5)alkyl-CO—O—(C1-C6)alkyl, ((C1-C6)alkyl)3Si—O-Si((C1-C6)alkyl)3, (C1-C5)alkyl-O—(C2-C5)alkyl and a mixture thereof; (c2) acetone; and (c3) one or more (C2-C3) alcohols and processes for its preparation. An adherent film, including: (a) one or more film forming agents; and (b) one or more disinfectants; and processes for its preparation.
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公开(公告)号：US11826028B2
公开(公告)日：2023-11-28
申请号：US16897328
申请日：2020-06-10
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Sridevi Dhanaraj , Ashley DeAnglis , Salim Ghodbane
CPC classification number: A61B17/0057 , A61L24/10 , A61L31/005 , A61L31/047 , A61L31/06 , A61L31/125 , A61L31/146 , A61L31/148 , A61B2017/00004 , A61B2017/0065 , A61L2400/04
Abstract: A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.
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公开(公告)号：US20180256776A1
公开(公告)日：2018-09-13
申请号：US15880650
申请日：2018-01-26
Applicant: UNIVERSITYOF UTAH RESEARCH FOUNDATION
Inventor： Russell J. STEWART
CPC classification number: A61L24/046 , A61K49/0043 , A61K49/0054 , A61K49/0073 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/02 , A61L24/043 , A61L24/10 , A61L24/104 , A61L2300/416 , A61L2300/44 , A61L2430/02 , A61L2430/36 , C09D5/1668 , C08L89/00
Abstract: Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
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公开(公告)号：US09931435B2
公开(公告)日：2018-04-03
申请号：US15137188
申请日：2016-04-25
Applicant: Warsaw Orthopedic, Inc.
Inventor： Jeffrey L. Scifert , William F. McKay
IPC: A61K9/70 , A61L27/24 , A61K9/00 , A61K9/16 , A61L27/58 , A61L24/00 , A61L24/10 , A61L27/46 , A61F2/02 , A61L24/02 , A61L27/02 , A61L27/54 , A61L27/56
CPC classification number: A61L27/24 , A61F2/02 , A61K9/0019 , A61K9/0024 , A61K9/1652 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/02 , A61L24/10 , A61L24/102 , A61L27/02 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45 , A61L2300/604 , A61L2400/06 , A61L2430/02 , A61L2430/38
Abstract: Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients.
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56.发明授权Joining and/or sealing tissues through photo-activated cross-linking of matrix proteins 有权通过基质蛋白的光激活交联连接和/或密封组织
公开(公告)号：US09579415B2
公开(公告)日：2017-02-28
申请号：US12223945
申请日：2007-02-14
Applicant: Alan George Brownlee , Christopher Malcolm Elvin
Inventor： Alan George Brownlee , Christopher Malcolm Elvin
CPC classification number: A61L24/106 , A61L24/0015 , A61L24/02 , A61L24/10 , A61L2400/04 , C08J3/24 , C08J2389/00 , C09J189/00
Abstract: A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivatable metal-ligand complex: thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.
Abstract translation: 一种在外科手术或医疗处理中接合和/或密封组织的方法，包括以下步骤：（1）将基质蛋白，可光活化的金属 - 配体复合物和电子受体施用于组织部分; （2）照射所述组织部分以激活可光活化的金属 - 配体络合物：由此引发基质蛋白质的交联反应以密封所述组织部分或将所述组织部分连接到相邻组织部分。
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57.发明申请
公开(公告)号：US20160310636A1
公开(公告)日：2016-10-27
申请号：US15137188
申请日：2016-04-25
Applicant: Warsaw Orthopedic, Inc.
Inventor： Jeffrey L. Scifert , William F. McKay
IPC: A61L27/24 , A61L27/56 , A61K9/00 , A61L24/00 , A61L27/54 , A61L27/46 , A61L24/10 , A61L24/02 , A61L27/02 , A61L27/58
CPC classification number: A61L27/24 , A61F2/02 , A61K9/0019 , A61K9/0024 , A61K9/1652 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/02 , A61L24/10 , A61L24/102 , A61L27/02 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45 , A61L2300/604 , A61L2400/06 , A61L2430/02 , A61L2430/38
Abstract: Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients.
Abstract translation: 描述了一种医学上有用的制品，其包括包含一种或多种可植入物质的三维体，其中所述主体限定用于接收生物相容性润湿液体量的一个或多个储存器。 在某些实施方案中，身体在与生物相容性液体润湿时形成适形植入材料，例如油灰，糊状物或更易流动的润湿植入材料。 还描述了制造这种医疗材料的方法，以及使用这种医疗材料来治疗患者的方法。
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公开(公告)号：US09302026B2
公开(公告)日：2016-04-05
申请号：US14591265
申请日：2015-01-07
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Erez Ilan , Kfir Regev , Israel Nur
CPC classification number: A61L24/043 , A61L24/0015 , A61L24/0042 , A61L24/10 , A61L24/106 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/45 , A61L2300/61 , A61L2400/04 , B65D81/32
Abstract: The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue.
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公开(公告)号：US20160051194A1
公开(公告)日：2016-02-25
申请号：US14802974
申请日：2015-07-17
Applicant: Biotronik SE & Co. KG
Inventor： Thomas DOERR , Michael DIEBOLD
CPC classification number: A61B5/688 , A61L24/0036 , A61L24/02 , A61L24/06 , A61L24/10 , A61L24/104 , A61L24/106 , A61L24/108 , A61N1/05 , A61N1/057 , A61N1/059 , A61N1/37205 , A61N1/3756 , A61N2001/058
Abstract: Embodiments include an implant for insertion into a human and/or animal body and an insertion device for the implant. The implant includes a housing, at least one negative pressure unit and at least one adhesive application unit to temporarily and/or permanently fix the implant to a bodily tissue.
Abstract translation: 实施例包括用于插入人和/或动物体的植入物和用于植入物的插入装置。 植入物包括壳体，至少一个负压单元和至少一个粘合剂施加单元，用于临时和/或永久地将植入物固定到身体组织上。
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公开(公告)号：US20150352246A1
公开(公告)日：2015-12-10
申请号：US14762424
申请日：2014-01-22
Applicant: PROLYNX LLC
Inventor： Jeffrey C. HENISE , Gary W. ASHLEY , Daniel V. SANTI
CPC classification number: A61L26/0019 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L24/06 , A61L24/10 , A61L26/0066 , A61L26/008 , A61L26/0085 , A61L26/009 , A61L2300/216 , A61L2300/604 , C09B11/24 , C09B57/02
Abstract: The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.
Abstract translation: 本发明提供了密封剂，其中任选地通过连接体为所述基团提供其中不另外包含用于结合膜或组织的蛋白质反应性基团的可生物降解的水凝胶。 接头可以是可生物降解的并且可以通过消除反应生物降解。 本发明还提供用于药物递送的多层凝胶，其中与药物将被递送的组织或器官接触的多孔凝胶被来自周围体液的微孔层保护。
