公开(公告)号：US20250051392A1

公开(公告)日：2025-02-13

申请号：US18796898

申请日：2024-08-07

Applicant: BicycleTx Limited

Inventor： Stephen J. Blakemore ,  Tara Gelb ,  Nicholas Keen ,  Michael Rigby

IPC: C07K7/08 ,  A61K31/40 ,  A61K31/5375 ,  A61K38/00 ,  A61K38/10 ,  A61K47/55 ,  A61K47/64 ,  A61K47/65 ,  A61P35/00

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

公开(公告)号：US20240173422A1

公开(公告)日：2024-05-30

申请号：US17769668

申请日：2020-10-15

Applicant: BICYCLETX LIMITED

Inventor： Paul Beswick ,  Gemma MUDD ,  Michael RIGBY

IPC: A61K47/64 ,  A61K47/60 ,  A61P35/00

CPC classification number: A61K47/64 ,  A61K47/60 ,  A61P35/00

Abstract: The present invention relates to drug conjugates comprising at least two polypeptides which are each covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also relates to pharmaceutical compositions comprising said drug conjugates and to the use of said drug conjugates in preventing, suppressing or treating diseases, such as those which may be alleviated by cell death, in particular diseases characterised by defective cell types, proliferative disorders such as cancer and autoimmune disorders such as rheumatoid arthritis.

公开(公告)号：US20240108737A1

公开(公告)日：2024-04-04

申请号：US18271333

申请日：2022-01-10

Applicant: BicycleTx Limited

Inventor： Nicholas KEEN ,  Gemma MUDD ,  Katerine VAN RIETSCHOTEN ,  Katie GAYNOR ,  Liuhong CHEN ,  Maximilian HARMAN ,  Michael SKYNNER ,  Paul BESWICK ,  Mehdi AMOURA ,  Simone GIORGI ,  Giulia LATTANZI ,  Iain LINGARD

IPC: A61K47/64 ,  A61P31/14

CPC classification number: A61K47/64 ,  A61P31/14

Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

公开(公告)号：US11866518B2

公开(公告)日：2024-01-09

申请号：US17223244

申请日：2021-04-06

Applicant: BicycleTx Limited

Inventor： Frank Narjes ,  Tor Svensson ,  Pavol Zlatoidsky ,  Lotta Hidestal ,  Liuhong Chen ,  Michael Skynner ,  Sophie Watcham

IPC: C07K7/64 ,  A61K47/54 ,  A61K38/00

CPC classification number: C07K7/64 ,  A61K47/545 ,  A61K38/00

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of thymic stromal lymphopoietin (TSLP). The invention also includes pharmaceutical compositions comprising said peptide ligands and to the use of said peptide ligands in preventing, suppressing or treating a disease or disorder mediated by TSLP.

公开(公告)号：US20240000957A1

公开(公告)日：2024-01-04

申请号：US18313983

申请日：2023-05-08

Applicant: BicycleTx Limited

Inventor： Liuhong CHEN ,  Philip HUXLEY ,  Silvia PAVAN ,  Katerine VAN RIETSCHOTEN

IPC: A61K47/64 ,  A61P35/00 ,  A61K47/65 ,  A61K38/10 ,  A61K38/05 ,  A61K47/62 ,  C07K7/08

CPC classification number: A61K47/6415 ,  A61P35/00 ,  A61K47/65 ,  A61K38/10 ,  A61K38/05 ,  A61K47/62 ,  C07K7/08 ,  A61K47/64

Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of the Eph receptor tyrosine kinase A2 (EphA2). The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder characterised by overexpression of EphA2 in diseased tissue (such as a tumour).

公开(公告)号：US11613560B2

公开(公告)日：2023-03-28

申请号：US16872097

申请日：2020-05-11

Applicant: BicycleTx Limited

Inventor： Tom Li Stephen ,  Kevin McDonnell ,  Nicholas Keen ,  Liuhong Chen ,  Helen Harrison ,  Peter U. Park ,  Michael Skynner ,  Harvey Che

IPC: C07K7/56 ,  A61K47/64

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to OX40. The invention also relates to multimeric binding complexes of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold that are functional agonists of OX40. The invention also includes drug conjugates comprising said peptides and complexes, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands, complexes and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by OX40.

公开(公告)号：US20230033370A1

公开(公告)日：2023-02-02

申请号：US17782910

申请日：2020-12-16

Applicant: BicycleTx Limited

Inventor： Paul BESWICK ,  Gemma MUDD

IPC: A61K47/64 ,  A61K47/54

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of IL-17. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by IL-17.

公开(公告)号：US20230021419A1

公开(公告)日：2023-01-26

申请号：US17782891

申请日：2020-12-16

Applicant: BicycleTx Limited

Inventor： Paul BESWICK ,  Gemma MUDD

IPC: C07K16/24 ,  C07K7/08

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of IL-17. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by IL-17.

公开(公告)号：US20230008076A1

公开(公告)日：2023-01-12

申请号：US17663169

申请日：2022-05-12

Applicant: BicycleTx Limited

Inventor： Nicholas KEEN ,  Kevin MCDONNELL ,  Peter PARK ,  Punit UPADHYAYA ,  Gemma Elizabeth MUDD

IPC: C07K14/00 ,  A61K38/12 ,  C07K7/08 ,  A61P35/00 ,  C07K7/50 ,  C07K7/06 ,  C07K14/705 ,  C07K14/715

Abstract: The present invention relates to heterotandem bicyclic peptide complexes which comprise a first peptide ligand, which binds to a component present on an immune cell, conjugated via a linker to a second peptide ligand, which binds to a component present on a cancer cell. The invention also relates to the use of said heterotandem bicyclic peptide complexes in preventing, suppressing or treating cancer.

公开(公告)号：US20220306694A1

公开(公告)日：2022-09-29

申请号：US17655822

申请日：2022-03-22

Applicant: BicycleTx Limited

Inventor： Gemma MUDD ,  Punit Upadhyaya ,  Kevin Mcdonnell

IPC: C07K11/02

Abstract: The present invention relates to heterotandem bicyclic peptide complexes which comprise a first peptide ligand, which binds to a component present on a cancer cell, conjugated via a linker to a second peptide ligand, which binds to a component present on an immune cell. The invention also relates to the use of said heterotandem bicyclic peptide complexes in preventing, suppressing or treating cancer.