公开(公告)号：US20210338426A1

公开(公告)日：2021-11-04

申请号：US17335845

申请日：2021-06-01

申请人： CARDIOVALVE LTD.

发明人： Yossi GROSS ,  Gil HACOHEN

IPC分类号： A61F2/24

摘要： An implant is configured to be coupled to first and second native leaflets of a native heart valve of a patient. The implant includes a proximal collar, a distal collar, and first and second clasps. Each of the first and second clasps has first and second tissue-engaging portions that are (1) disposed distal to the proximal collar and proximal to the distal collar, and (2) movable, with respect to each other, to clamp one of the leaflets between the first and second tissue-engaging portions of the clasp. The implant is configured such that, when the leaflets are clamped by the first and second clasps, the first and second clasps form the first and second native leaflets into a double orifice, each orifice configured to function as a respective check-valve. Other embodiments are also described.

公开(公告)号：US20210330456A1

公开(公告)日：2021-10-28

申请号：US17366711

申请日：2021-07-02

申请人： CARDIOVALVE LTD.

发明人： Gil Hacohen ,  Yossi Gross

IPC分类号： A61F2/24

摘要： Implantable first atrial and ventricular arms are articulatable at a first articulation site to clamp a first heart valve leaflet. A first elongate transitioning member is (a) connected at a fixed connection point at a portion of the first ventricular arm farthest from the first articulation site, (b) has a portion that faces an opposite surface of the first ventricular arm, and (c) is controllable to move the first ventricular arm. Implantable second atrial and ventricular arms are articulatable at a second articulation site to clamp a second leaflet. A second elongate transitioning member is (a) connected at a fixed connection point at a portion of the second ventricular arm farthest from the second articulation site, (b) has a portion that faces an opposite surface of the second ventricular arm, and (c) is controllable to move the second ventricular arm. Other embodiments are also described.

公开(公告)号：US11135059B2

公开(公告)日：2021-10-05

申请号：US16802353

申请日：2020-02-26

申请人： CARDIOVALVE LTD.

发明人： Tal Hammer ,  Yuval Zipory ,  Tal Reich ,  Yaron Herman ,  Gil Hacohen ,  Eran Miller ,  Rotem Neeman ,  Natalia Kruglova

IPC分类号： A61F2/24

摘要： Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US10905548B2

公开(公告)日：2021-02-02

申请号：US16135770

申请日：2018-09-19

申请人： CARDIOVALVE LTD.

发明人： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC分类号： A61F2/24

摘要： An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.

公开(公告)号：US20200046497A1

公开(公告)日：2020-02-13

申请号：US16660231

申请日：2019-10-22

申请人： CARDIOVALVE LTD.

发明人： Ilia HARITON ,  Boaz HARARI

IPC分类号： A61F2/24

摘要： Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a method of implanting a prosthetic valve within a native heart valve may be provided. The method may include delivering the prosthetic valve into a heart chamber while the prosthetic valve is constrained in a radially-contracted delivery configuration. The method may also include unconstraining ventricular tissue anchors and atrial tissue anchors of the prosthetic valve while maintaining an annular valve body of the prosthetic valve in the delivery configuration. The method may also include unconstraining the annular valve body from the delivery configuration while the unconstrained atrial tissue anchors and ventricular tissue anchors are positioned within an atrium and a ventricle, respectively. Unconstraining the annular valve body may decrease a longitudinal distance between the ventricular tissue anchors and atrial tissue anchors to secure the prosthetic valve within the native heart valve.

公开(公告)号：US20190083262A1

公开(公告)日：2019-03-21

申请号：US16135447

申请日：2018-09-19

申请人： CARDIOVALVE LTD.

发明人： LLIA HARITON ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC分类号： A61F2/24

摘要： A heart valve delivery system may be provided. The heart valve delivery system may include at least a first catheter movable relative to second and third catheters, arranged in a telescoping configuration. The second catheter may be movable relative to and extend from the distal end of the third catheter. The delivery system may include a first adjustable flexure radius associated with the second catheter, and a second flexure radius. The delivery system may include at one control handle assembly configured to permit the catheters to rotate together, independently adjust the first and second flexure radii, cause relative axial movement between the catheters, and permit the ejector to cause relative movement between a heart valve and a capsule connected to the first catheter.

公开(公告)号：US20190083251A1

公开(公告)日：2019-03-21

申请号：US16136082

申请日：2018-09-19

申请人： CARDIOVALVE LTD.

发明人： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC分类号： A61F2/24

摘要： Prosthetic valves and methods of implanting prosthetic valves may be provided, including an expandable prosthetic valve for implantation within a native heart valve. The prosthetic valve may include an annular valve body and atrial anchoring arms configured to extend radially outward from the annular valve body. Each atrial anchoring arm may have a proximal arm end and a distal arm end. The flexibility of at least one atrial anchoring arm may vary substantially from the proximal arm end thereof to the distal arm end thereof. The prosthetic valve may also include a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. Each ventricular anchoring leg may have a proximal leg end and a distal leg end. Each ventricular anchoring leg may have a substantially constant flexibility from the proximal leg end to the distal leg end.

公开(公告)号：US20190083250A1

公开(公告)日：2019-03-21

申请号：US16136074

申请日：2018-09-19

申请人： CARDIOVALVE LTD.

发明人： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC分类号： A61F2/24

摘要： A prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body, as well as a plurality of ventricular anchoring legs and a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body. The ventricular anchoring legs and grasping segments of the atrial anchoring arms may be configured to substantially restrict axial movement of the annular valve body within the native heart valve. In addition, anchoring segments of the atrial anchoring arms may be configured for lateral deformation relative to the native heart valve.

公开(公告)号：US20190083244A1

公开(公告)日：2019-03-21

申请号：US16135599

申请日：2018-09-19

申请人： CARDIOVALVE LTD.

发明人： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC分类号： A61F2/24

摘要： An expandable prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an expandable valve body having an atrial end, a ventricular end opposite the atrial end, and an intermediate portion extending between the atrial end and the ventricular end. The valve body may include a plurality of struts intersecting at junctions. The prosthetic valve may also include a plurality of tissue anchoring legs extending from junctions within the intermediate portion of the valve body. At least one of the tissue anchoring legs may have a cross-sectional area which is larger by at least 20% than a cross-sectional area of a strut extending between the at least one tissue anchoring leg and an adjacent tissue anchoring leg.

公开(公告)号：USD841812S1

公开(公告)日：2019-02-26

申请号：US29635658

申请日：2018-02-01

申请人： MITRAL TECH LTD.

设计人： Ilia Hariton ,  Boaz Harari ,  Meni Iamberger ,  Aviram Baum