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公开(公告)号：US20200030025A1
公开(公告)日：2020-01-30
申请号：US16590239
申请日：2019-10-01
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Benjamyn Serna , Jesus Magana , Michael Ngo , John Stankus
IPC: A61B18/14
Abstract: A method for manufacturing a shaping structure having a generally helical profile and configured to support electrodes for delivering electric energy into a cylindrical lumen of a patient. The method comprises providing a mandrel with a circular cylindrical shape and forming a first hole in the mandrel along the elongate axis, such that opposing ends of a bore of the first hole emerge at the proximal end and at the distal end; forming a second hole in the mandrel to extend from the curved surface to connect with the first hole; wrapping a metal wire around the mandrel; and inserting opposing ends of the metal wire into the second and the third hole respectively, and threading the opposing ends of the metal wire until they emerge from the opposing ends of the bore of the first hole; finally, heating the mandrel and the wire.
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公开(公告)号：US10448994B2
公开(公告)日：2019-10-22
申请号：US14994868
申请日：2016-01-13
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Benjamyn Serna , Jesus Magana , Michael Ngo , John Stankus
Abstract: A method for manufacturing a shaping structure having a generally helical profile and configured to support electrodes for delivering electric energy into a cylindrical lumen of a patient. The method comprises providing a mandrel with a circular cylindrical shape and forming a first hole in the mandrel along the elongate axis, such that opposing ends of a bore of the first hole emerge at the proximal end and at the distal end; forming a second hole in the mandrel to extend from the curved surface to connect with the first hole; wrapping a metal wire around the mandrel; and inserting opposing ends of the metal wire into the second and the third hole respectively, and threading the opposing ends of the metal wire until they emerge from the opposing ends of the bore of the first hole; finally, heating the mandrel and the wire.
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公开(公告)号：US20170095361A1
公开(公告)日：2017-04-06
申请号：US15383821
申请日：2016-12-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： John Stankus , Benjamyn Serna
CPC classification number: A61F2/915 , A61F2/958 , A61F2002/91566 , A61F2002/9522 , A61F2240/001 , Y10T29/49908 , Y10T29/49925 , Y10T29/49936
Abstract: A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon while retaining, at least partially, the original balloon folds as the balloon is pressurized and de-pressurized within a crimper head. By at least partially retaining the original balloon folds, a uniformity of scaffold expansion by the balloon is improved.
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公开(公告)号：US20160175040A1
公开(公告)日：2016-06-23
申请号：US14574664
申请日：2014-12-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Jesus Magana , John Stankus , Benny Serna , Michael Ngo
CPC classification number: A61B18/1492 , A61B2017/00526 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61M25/04
Abstract: A catheter apparatus defining a first lumen with a first internal diameter, the catheter apparatus further comprising a shaping structure having a distal end and a proximal end and a length therebetween, the shaping structure being moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. A deployment member having a second lumen with a second internal diameter, a first portion of the deployment member being positioned within the first lumen and having a third outside diameter sized to enable the deployment member to slide within the first lumen, the deployment member being operably coupled to the distal end of the shaping structure and being configured such that distal axial movement of the deployment member places the shaping structure in the delivery state, and proximal axial movement of the deployment member places the shaping structure in the deployed state.
Abstract translation: 导管装置限定具有第一内径的第一腔，所述导管装置还包括具有远端和近端以及其间的长度的成形结构，所述成形结构可在具有第一螺旋形状的输送状态和在具有第一螺旋形状的输送状态之间移动， 具有第二螺旋形状的展开状态。 具有第二内腔的展开构件具有第二内径，所述展开构件的第一部分定位在所述第一内腔内并且具有尺寸适于使所述展开构件能够在所述第一内腔内滑动的第三外径，所述展开构件可操作地 联接到成形结构的远端并且被构造成使得展开构件的远侧轴向移动使成形结构处于输送状态，并且展开构件的近侧轴向运动将成形结构置于展开状态。
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45.发明申请Methods and Devices for Treating a Bodily Lumen with In Situ Generated Structural Support 审中-公开用原位生成的结构支持治疗身体的方法和装置
公开(公告)号：US20150305892A1
公开(公告)日：2015-10-29
申请号：US14262516
申请日：2014-04-25
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed Hossainy , Krishna Sudhir , John Stankus , Mikael Trollsas
CPC classification number: A61F2/50 , A61F2/82 , A61F2210/0004 , A61F2210/0085 , A61L27/18 , A61L27/50 , A61L27/58 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , A61L2300/624 , A61L2400/06 , A61L2400/12 , C08L67/04 , C08L71/02
Abstract: A bodily lumen, such as a blood vessel, can be treated by forming a structural support in situ within the bodily lumen. This can be done by ejecting a formulation that includes a polymer that solidifies over a period of time, such as due to DMSO exchange or photocrosslinking. This can also be done by cooling a formulation until it freezes in situ. The structural support can also be made from a plaque which is already present in the bodily lumen. The plaque can be compressed by a balloon catheter and cooled so that it hardens and thereby forms the structural support. The bodily lumen can also be treated using a preformed structural support made of ice, for example frozen isotonic saline, or a fast degrading polymer, such as PEG. The preformed support is created outside of the bodily lumen, and then transported on a catheter to the treatment zone.
Abstract translation: 可以通过在体腔内原位形成结构支架来治疗诸如血管的体腔。 这可以通过喷射包括在一段时间内固化的聚合物的制剂来实现，例如由于DMSO交换或光致交联。 这也可以通过冷却制剂直到其原位冻结来完成。 结构支撑物也可以由已经存在于体腔中的斑块制成。 斑块可以通过气囊导管压缩并冷却，使得其硬化并由此形成结构支撑。 还可以使用由冰制成的预制结构支撑物例如冷冻等渗盐水或快速降解聚合物例如PEG来处理身体腔。 预先形成的支撑体在体腔外部产生，然后在导管上运送到治疗区域。
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公开(公告)号：US20140212355A1
公开(公告)日：2014-07-31
申请号：US13752281
申请日：2013-01-28
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Mikael TROLLSAS , Syed Hossainy , John Stankus , Paul Consigny
IPC: A61K9/00
CPC classification number: A61L31/145 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2400/12 , A61L2430/36 , C08L67/04 , C08L71/02
Abstract: It is provided herein methods, devices, and compositions for trans-arterial local delivery of therapeutic agent for the treatment of liver cancers.
Abstract translation: 本文提供用于治疗肝癌的治疗剂的跨动脉局部递送的方法，装置和组合物。
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公开(公告)号：US20140186446A1
公开(公告)日：2014-07-03
申请号：US14142651
申请日：2013-12-27
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , John Stankus , James Su , Syed Hossainy , Joshua Takeshi Smith , Shadid Askar
CPC classification number: A61K9/146 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K38/215 , A61K47/10 , A61K2039/505 , C07K16/241 , C07K16/40 , C07K2317/21
Abstract: Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.
Abstract translation: 公开了提供对体内空间的生物治疗剂的受控的持续释放的制剂和方法。 更具体地，公开了包含多个亲水性聚合物链的制剂，以及形成和施用这些制剂的方法。 在一些实施方案中，制剂在生物治疗的三十至九十天内显示爆发释放，初始释放，三相释放和释放。 在一些实施方案中，制剂将生物治疗剂的可逆沉淀显示为具有约50nm至约10μm直径的沉淀物。
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公开(公告)号：US20140046254A1
公开(公告)日：2014-02-13
申请号：US14054797
申请日：2013-10-15
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： John Stankus , Mikael Trollsas , Syed Hossainy , Zhang Liangxuan , Ed Berger , Stephen Pacetti , John L. Toner
CPC classification number: A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
Abstract: A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
Abstract translation: 提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。 根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。 或者，至少30％的涂层在充气后一分钟内从气球表面转移。 涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。
