公开(公告)号：US20250064976A1

公开(公告)日：2025-02-27

申请号：US18948601

申请日：2024-11-15

Applicant: The Broad Institute, Inc. ,  Massachusetts Institute of Technology

Inventor： Feng Zhang ,  Victoria Madigan ,  Yugang Zhang ,  Rumya Raghavan ,  Max Wilkinson ,  Guilhem Faure ,  Rhiannon Macrae

IPC: A61K48/00 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

Abstract: Described herein are engineered paraneoplastic Ma protein (PNMA) capable of forming a capsid. In some embodiments, the engineered PNMA proteins comprise one or more modifications that enhance binding or loading of a cargo into the capsid, one or more modifications that modify cell-specificity of the capsid, one or more modifications that enhance intracellular delivery of the capsid, or a combination thereof. Also described herein are delivery systems comprising capsids comprising an engineered PNMA protein and a cargo.

公开(公告)号：US20250051800A1

公开(公告)日：2025-02-13

申请号：US18915537

申请日：2024-10-15

Applicant: The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  Massachusetts Institute of Technology

Inventor： Pardis Sabeti ,  Mohammadsharif Tabebordbar ,  Simon Ye

IPC: C12N15/86 ,  A61K31/7088 ,  A61K47/64 ,  A61K48/00 ,  C07K7/06 ,  C07K14/005 ,  C07K14/47 ,  C12N9/22 ,  C12N15/11

Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.

公开(公告)号：US12223265B2

公开(公告)日：2025-02-11

申请号：US17855248

申请日：2022-06-30

Applicant: Qatar Foundation for Education, Science and Community Development ,  Massachusetts Institute of Technology

Inventor： Preslav I. Nakov ,  Giovanni Da San Martino ,  Seunghak Yu

IPC: G06F40/205 ,  G06F3/04842 ,  G06F40/289

Abstract: Explainable propaganda detection is provided by parsing each sentence of a plurality of sentences in an article for structural details; identifying, via a machine learning model, dimensional features across the plurality of sentences based on the structural details; identifying, via the machine learning model, a propagandizing tactic demonstrated in each sentence of the plurality of sentences based a covariance score to the propagandizing tactic and the plurality of dimensional features identified for a given sentence; and displaying, in a user interface that includes the article, propaganda labels corresponding to the propagandizing tactic identified for each sentence of the plurality of sentences.

公开(公告)号：US20250047016A1

公开(公告)日：2025-02-06

申请号：US18765682

申请日：2024-07-08

Applicant: Massachusetts Institute of Technology ,  Commonwealth Fusion Systems LLC

Inventor： Christopher CRAIGHILL ,  Alexey RADOVINSKY ,  Rui VIEIRA ,  Vincent FRY ,  Colin O'SHEA ,  Sera EVCIMEN

IPC: H01R4/68 ,  H01B12/02

Abstract: Described is a partitioned cable joint comprising a plurality of physically distributed joint elements with the plurality of joint elements taken together defining a joint length. Joint elements may have a first mounting region having a shape selected to accept one petal of superconducting cable and a second mounting region having a shape selected to accept one petal of a second conductor.

公开(公告)号：US20250045185A1

公开(公告)日：2025-02-06

申请号：US18228423

申请日：2023-07-31

Applicant: International Business Machines Corporation ,  Massachusetts Institute of Technology

Inventor： Zilu Tang ,  Mayank Agarwal ,  JIE CHEN ,  Alexander Gregory Shypula ,  Bailin Wang ,  Yoon Hyung Kim

IPC: G06F11/36 ,  G06F8/51 ,  G06F40/47 ,  G06F40/51

Abstract: One or more unit-test cases are generated from a monolingual code corpus and the generated unit-test cases are filtered to generate a corpus of unit-test cases which have acceptability scores exceeding one or more predefined thresholds. One or more of the code samples of the monolingual code corpus are translated from a source language to a target language using a pretrained Large Language Model and the generated unit-test cases are translated from the source language to the target language. The LLM-translated code samples are validated using the translated unit-test cases and a parallel-data training corpus comprising the LLM-translated code samples that pass the validation is created. The pretrained large language model (LLM) is fine-tuned using the parallel-data training corpus, a given code segment is translated using the fine-tuned large language model (LLM), the translated given code segment is tested and the tested given code segment is deployed.

公开(公告)号：US20250043283A1

公开(公告)日：2025-02-06

申请号：US18749007

申请日：2024-06-20

Applicant: Sarepta Therapeutics, Inc. ,  Massachusetts Institute of Technology

Inventor： Kyle A. Totaro ,  Mark D. Simon ,  Ming Zhou ,  Hong Zong ,  Gunnar J. Hanson ,  Bradley L. Pentelute

IPC: C12N15/113

Abstract: Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomersynthesis while maintaining overall yield and purity of a synthesized oligomer.

公开(公告)号：US12215206B2

公开(公告)日：2025-02-04

申请号：US18448894

申请日：2023-08-11

Applicant: Massachusetts Institute of Technology

Inventor： Jeonyoon Lee ,  Brian L. Wardle ,  Diana Jean Lewis

IPC: C08J5/00 ,  C01B32/15 ,  C01B32/16 ,  C08J5/24

Abstract: Methods and systems for the fabrication of composite materials are generally described. Certain inventive methods and systems can be used to fabricate composite materials with few or no defects. According to certain embodiments, composite materials are fabricated without the use of an autoclave. In some embodiments, composite materials are fabricated in low pressure environments.

公开(公告)号：US12208344B2

公开(公告)日：2025-01-28

申请号：US17969608

申请日：2022-10-19

Applicant: Massachusetts Institute of Technology

Inventor： Kripa K. Varanasi ,  Leonid Rapoport

IPC: B01D19/00 ,  B01D19/02 ,  C02F1/20

Abstract: Foam mitigation using a variety of articles, systems, and methods is generally described. According to certain embodiments, surfaces with certain wetting properties can be used to reduce or eliminate the formation of foam from bubble-containing liquids. In some embodiments, a surface with certain wetting properties is configured and/or arranged within bubble-containing liquids such that the surface provides a gaseous fluidic pathway through which gas from the bubbles within the liquid may be channeled to a gaseous environment outside the liquid.

公开(公告)号：US20250027204A1

公开(公告)日：2025-01-23

申请号：US18710382

申请日：2021-11-15

Applicant: Massachusetts Institute of Technology

Inventor： Jennifer Lilia Rupp ,  Yuntong Zhu ,  Lingping Kong ,  Moran Balaish

IPC: C23C18/12 ,  G01N33/00

Abstract: A method for making a lithium salt film includes heating a substrate, spraying a mixture with a spray nozzle onto the substrate to form a precursor film, and annealing the precursor film to form the lithium salt film. The lithium salt film has a thickness of about 400 nm to about 100 pm. The spray mixture includes a first precursor comprising a lithium ion, a second precursor comprising an anion, and a solvent.

公开(公告)号：US20250026871A1

公开(公告)日：2025-01-23

申请号：US18553976

申请日：2022-04-04

Applicant: University of Washington ,  Massachusetts Institute of Technology (M.I.T.)

Inventor： Matthew Golder ,  Teng-Wei Wang ,  Jeremiah A. Johnson

IPC: C08F132/04 ,  C07F15/00

Abstract: Cyclic ruthenium benzylidene initiators useful for the controlled synthesis of functionalized cyclic macromolecules via ring-expansion metathesis polymerization.