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公开(公告)号：US08208189B2
公开(公告)日：2012-06-26
申请号：US12102739
申请日：2008-04-14
CPC分类号： A61K48/0075 , A61K48/0091
摘要： A method of restoring hair to skin that has suffered hair loss includes optically ablating an array of spaced-apart microchannels or voids into the skin and transplanting into the voids stem cells, a scaffold and a differentiation factor for causing the stem cells to differentiate into hair follicles.
摘要翻译： 一种将头发恢复成脱发的方法包括将间隔开的微通道或空隙的阵列光学消融到皮肤中并移植到空隙干细胞中，支架和分化因子，以使干细胞分化为毛发 滤泡。
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公开(公告)号：US20110137302A1
公开(公告)日：2011-06-09
申请号：US13026697
申请日：2011-02-14
摘要： An optical pattern uses a single rotating component. The rotating component includes a number of deflection sectors. Each sector deflects an incident optical beam by a substantially constant angular amount although this amount may vary from one sector to the next. The rotating component may be combined with an imaging lens group that produces, for example, image points, spots, or lines displaced along a line locus.
摘要翻译： 光学图案使用单个旋转部件。 旋转部件包括多个偏转扇区。 每个扇区将入射光束偏转大致恒定的角度量，尽管该量可以从一个扇区到下一个扇区变化。 旋转分量可以与产生例如图像点，点或沿着线轨迹移位的线的成像透镜组组合。
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43.发明授权公开(公告)号：US07938821B2
公开(公告)日：2011-05-10
申请号：US11777965
申请日：2007-07-13
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B18/20 , A61B2018/00452 , A61B2018/00636 , A61B2018/20351
摘要： A fractional treatment system can be configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue increases as the tissue is heated by the laser (e.g., 1390-1425 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 8 cm−1 to about 30 cm−1. An adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. The system may be designed to be switchable between a treatment mode that is semi-ablative and a treatment mode that is not semi-ablative. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements.
摘要翻译： 分数处理系统可以配置有激光波长，其被选择为使得组织内的激光波长的吸收随着组织被激光加热（例如，1390-1425nm）而增加。 理想地，激光波长主要被水吸收在皮肤处理区域内，并且热调节的吸收系数在约8cm -1至约30cm -1的范围内。 可以使用可调节的机构来调整光束形状，光束数值孔径，光束聚焦深度和/或光束尺寸，以影响治疗深度和所得病变的特征。 该系统可以被设计为在半烧蚀的治疗模式和不是半烧蚀的治疗模式之间切换。 这些参数的调整可以提高治疗的效率和疗效。 可调节机构的说明性实例包括一组不同长度的间隔物，具有不同焦距的透镜元件的可旋转转台，光学变焦透镜和用于调节两个光学透镜元件之间的间距的机械调节装置。
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44.发明申请Apparatus and Method for Adjustable Fractional Optical Dermatological Treatment 有权可调分数光学皮肤病治疗的装置和方法公开(公告)号：US20110098691A1
公开(公告)日：2011-04-28
申请号：US12955396
申请日：2010-11-29
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B18/20 , A61B2018/00452 , A61B2018/00636 , A61B2018/20351
摘要： In a fractional treatment system, an adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements. In one aspect, the fractional treatment is configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue decreases as the tissue is heated by the laser (e.g., 1480-1640 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 7 cm−1 to about 26 cm−1.
摘要翻译： 在分数处理系统中，可以使用可调节的机构来调整光束形状，光束数值孔径，光束聚焦深度和/或光束尺寸，以影响治疗深度或所得损伤的特征。 这些参数的调整可以提高治疗的效率和疗效。 可调节机构的说明性实例包括一组不同长度的间隔物，具有不同焦距的透镜元件的可旋转转台，光学变焦透镜和用于调节两个光学透镜元件之间的间距的机械调节装置。 在一个方面，分数处理配置有激光波长，激光波长被选择为使得组织内的激光波长的吸收随着组织被激光加热而减小（例如，1480-1640nm）。 理想地，激光波长主要被水吸收在皮肤处理区域内，并且热调节的吸收系数在约7cm -1至约26cm -1的范围内。
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45.发明授权Method and apparatus for monitoring and controlling thermally induced tissue treatment 失效用于监测和控制热诱导组织处理的方法和装置公开(公告)号：US07824395B2
公开(公告)日：2010-11-02
申请号：US11468275
申请日：2006-08-29
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B18/14 , A61B34/20 , A61B2017/00022 , A61B2017/00106 , A61B2018/00452 , A61B2018/00476 , A61B2034/2048 , A61B2034/2051 , A61B2034/2055 , A61B2034/2059 , A61B2034/2063 , A61B2034/2065 , A61B2090/373 , A61B2090/378 , A61B2090/395 , A61B2090/3958 , A61N5/062
摘要： A method and apparatus for thermal treatment of tissue by irradiating the skin with electromagnetic energy is disclosed. Sources of electromagnetic energy include radio frequency (RF) generators, lasers, and flashlamps. The apparatus includes either a positional sensor or a dosage evaluation sensor, or both types of sensors. These sensors provide feedback to a controller. The controller may control the electromagnetic source parameters, the electromagnetic source activation, and/or the sensor measurement parameters. An additional scanning delivery unit may be operably coupled to the controller or to the sensors to provide a controlled distribution of electromagnetic energy to the target region of the skin. The use of positional measurement sensors and dosage evaluation sensors permits the controller to automatically determine the proper electromagnetic source parameters including, for example, pulse timing and pulse frequency.
摘要翻译： 公开了一种通过用电磁能照射皮肤来热处理组织的方法和装置。 电磁能源包括射频（RF）发生器，激光器和闪光灯。 该装置包括位置传感器或剂量评估传感器，或两种类型的传感器。 这些传感器向控制器提供反馈。 控制器可以控制电磁源参数，电磁源激活和/或传感器测量参数。 附加的扫描传送单元可以可操作地耦合到控制器或传感器，以向皮肤的目标区域提供受控的电磁能量分布。 使用位置测量传感器和剂量评估传感器允许控制器自动确定适当的电磁源参数，包括例如脉冲定时和脉冲频率。
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公开(公告)号：US07646522B2
公开(公告)日：2010-01-12
申请号：US12119461
申请日：2008-05-12
IPC分类号： G02B26/08
摘要： An optical pattern uses a single rotating component. The rotating component includes a number of deflection sectors. Each sector deflects an incident optical beam by a substantially constant angular amount although this amount may vary from one sector to the next. The rotating component may be combined with an imaging lens group that produces, for example, image points, spots, or lines displaced along a line locus.
摘要翻译： 光学图案使用单个旋转部件。 旋转部件包括多个偏转扇区。 每个扇区将入射光束偏转大致恒定的角度量，尽管该量可以从一个扇区到下一个扇区变化。 旋转分量可以与产生例如图像点，点或沿着线轨迹移位的线的成像透镜组组合。
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公开(公告)号：US07557975B2
公开(公告)日：2009-07-07
申请号：US11952925
申请日：2007-12-07
IPC分类号： G02B26/08
CPC分类号： G02B26/105 , G02B13/0095 , G02B26/0875 , G02B26/10 , G02B27/30 , Y10S359/90
摘要： An optical pattern generator includes one or more multi-faceted rotating optical elements that introduce an offset that is rotation insensitive. The component that generates the offset is rotationally symmetric around the rotational axis of the optical element. Thus, as the optical element rotates, the effect of the offset component does not change. In addition, rotating optical elements may be designed to counteract unwanted optical effects of each other.
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公开(公告)号：US07480086B2
公开(公告)日：2009-01-20
申请号：US11849745
申请日：2007-09-04
IPC分类号： G02B26/08
CPC分类号： G02B26/105 , G02B13/0095 , G02B26/0875 , G02B26/10 , G02B27/30 , Y10S359/90
摘要： An optical pattern generator includes one or more multi-faceted rotating optical elements that introduce an offset that is rotation insensitive. The component that generates the offset is rotationally symmetric around the rotational axis of the optical element. Thus, as the optical element rotates, the effect of the offset component does not change. In addition, rotating optical elements may be designed to counteract unwanted optical effects of each other.
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公开(公告)号：US20080252956A1
公开(公告)日：2008-10-16
申请号：US12119461
申请日：2008-05-12
IPC分类号： G02B26/08
摘要： An optical pattern uses a single rotating component. The rotating component includes a number of deflection sectors. Each sector deflects an incident optical beam by a substantially constant angular amount although this amount may vary from one sector to the next. The rotating component may be combined with an imaging lens group that produces, for example, image points, spots, or lines displaced along a line locus.
摘要翻译： 光学图案使用单个旋转部件。 旋转部件包括多个偏转扇区。 每个扇区将入射光束偏转大致恒定的角度量，尽管该量可以从一个扇区到下一个扇区变化。 旋转分量可以与产生例如图像点，点或沿着线轨迹移位的线的成像透镜组组合。
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公开(公告)号：US07413572B2
公开(公告)日：2008-08-19
申请号：US10868134
申请日：2004-06-14
IPC分类号： A61N5/06
CPC分类号： A61B18/203 , A61B18/20 , A61B2017/00022 , A61B2017/00084 , A61B2018/00452 , A61B2018/00636 , A61B2018/20351
摘要： Tissue is treated by irradiating it with a sequence of optical pulses that are directed in sequence to various sites on the tissue. During the irradiation sequence, one or more tissue properties are measured at a site(s) that has already been irradiated. These measurements are used to adjust the parameters of subsequent optical pulses in the sequence.
摘要翻译： 通过用顺序指向组织上的各个部位的光脉冲序列照射组织来治疗组织。 在照射序列期间，在已经被照射的位点处测量一个或多个组织性质。 这些测量用于调整序列中后续光脉冲的参数。
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