公开(公告)号：US07238683B2

公开(公告)日：2007-07-03

申请号：US10573108

申请日：2004-10-29

申请人： Wallace T. Ashton ,  Hong Dong ,  Jinyou Xu

发明人： Wallace T. Ashton ,  Hong Dong ,  Jinyou Xu

IPC分类号： C07D207/04 ,  C07D401/10 ,  C07D403/10 ,  C07D487/04 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/4725 ,  A61P3/10

CPC分类号： C07D207/10 ,  A61K38/00 ,  C07D205/04

摘要： The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-RV抑制剂”）的抑制剂的稠合苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。