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公开(公告)号：US12187781B2
公开(公告)日：2025-01-07
申请号：US17264707
申请日：2019-08-01
Applicant: Regents of the University of Minnesota
Inventor： Marc Kevin Jenkins , Thamotharampillai Dileepan , Deepali Malhotra
IPC: G01N33/50 , C07K14/74 , G01N33/543 , G01N33/58
Abstract: The present disclosure provides variant major histocompatibility complex class II (MHCII) beta chains, as well as heterodimers and multimers including MHCII alpha chains and the variant MHCII beta chains. Also provided by the present disclosure are nucleic acids, expression cassettes, and expression vectors encoding the MHCII beta chains. The heterodimers and multimers of the present disclosure have a higher affinity for CD4 co-receptors than comparable reagents including wild type MHCII beta chains, and therefore are advantageous for use in methods of phenotyping or activating CD4+ T cells.
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公开(公告)号：US20250003985A1
公开(公告)日：2025-01-02
申请号：US18707589
申请日：2022-11-07
Applicant: Rallybio IPA, LLC
Inventor： Douglas L. Sheridan , Jonathan Reeves , Julien Rainville Sirois
IPC: G01N33/68 , C12Q1/6804 , G01N33/543 , G01N33/58
Abstract: Methods of quantifying anti-HPA-1a antibodies in a sample, comprising (a) contacting the sample with a capture reagent that binds to the anti-HPA-1a antibodies to form a detection complex, wherein the capture reagent comprises a modified integrin psi and (b) measuring an amount of the detection complex, wherein the amount of the detection complex indicates the quantity of the anti-HPA-1a antibodies in the sample. The methods may also comprise contacting the sample with a detecting reagent that binds to the anti-HPA-1a antibodies and becomes part of the detection complex. The capture reagent and/or the detecting reagent may comprise a detection label, in which measuring the amount of the detection complex comprises measuring the amount of the detectable label.
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公开(公告)号：US20250003967A1
公开(公告)日：2025-01-02
申请号：US18711553
申请日：2022-11-18
Inventor： Jeong-Yeol Yoon
IPC: G01N33/569 , G01N33/543 , G01N33/58 , G01N33/68
Abstract: The present disclosure provides kits and methods for detecting and/or quantifying coronavirus from aerosols and droplets.
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公开(公告)号：US20250003961A1
公开(公告)日：2025-01-02
申请号：US18827348
申请日：2024-09-06
Inventor： Toshifumi TAKEUCHI , Yukiya KITAYAMA , Hirobumi SUNAYAMA
IPC: G01N33/543
Abstract: A material for producing a sensor for analysis of a detection target, including: a base material; and a polymer film provided on a surface of the base material, wherein the polymer film includes a concave that receives the detection target, and inside the concave is a group for binding an antibody substance and a group for binding a signal substance, wherein the group for binding the antibody substance is attached to the base material and is only accessible by the antibody substance through a clearing in the polymer film within the concave, wherein the group for binding the antibody substance is not accessible by the antibody substance on any part of the surface of the base material other than within the concave, and wherein the group for binding the signal substance is attached to the polymer within the concave and is not accessible by the signal substance on any part of the polymer film other than within the concave.
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公开(公告)号：US20250001417A1
公开(公告)日：2025-01-02
申请号：US18190927
申请日：2023-03-27
Applicant: Rula Abbud-Antaki
Inventor： Rula Abbud-Antaki
Abstract: The present invention describes kits and methods for rapid detection of nucleic acid sequences in real-time and in any setting. Unique features of this kit include isothermal nucleic acid extraction in Unit 1, and amplification, labeling, and signal detection in Unit 2 (FIG. 1). These units can be operated separately with manual transfer of product from one to the other or can be put together in a fashion where user places sample into inlet of Unit 1 and observes results in detection chamber of Unit 2. Several versions of this kit can be developed using different sequence-specific primers and probes to detect any nucleic acid sequence (DNA or RNA) in a multiplex fashion. In a preferred embodiment, visual detection of amplified signal is done using Lateral Flow Strips, eliminating the need for any additional complex equipment. Such a kit can be easily developed and manufactured to assist in the mitigation response to any pandemic, especially for COVID-19. The COVID-19 kit is called an At-Home COVID test (AH-COV).
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公开(公告)号：US12181471B2
公开(公告)日：2024-12-31
申请号：US18176144
申请日：2023-02-28
Applicant: SciKare, Inc.
Inventor： Prajakta Kulkarni
IPC: G01N33/543 , A61B10/00 , E03D9/00
Abstract: A non-invasive system and method for disease detection and real-time monitoring of organ health wherein the changes in the electrical properties of urine samples are studied over time in the presence or absence of interacting chemicals for qualitative and quantitative estimation of urinary analytes. The system has two components—a test platform and a reader. The test platform is integrated with electrodes and chemicals, which interact with urine to detect the biomarker of the disease and quantify the analyte. The changes in the electrical properties serve as an electrical signature for a particular analyte. This electrical signal from the test platform is relayed to an electronic reader that receives, processes, and analyzes the data for single test detection or continuous monitoring. The reader stores the information that can then be coupled to a readout system or transmitted by wired or wireless mechanisms to any electronic platform in real-time.
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公开(公告)号：US12178592B2
公开(公告)日：2024-12-31
申请号：US17411511
申请日：2021-08-25
Applicant: Abbott Laboratories
Inventor： Beth McQuiston , Frederick Korley , Agim Beshiri , Jaime Marino , Saul Datwyler
IPC: A61B5/00 , C12Q1/6883 , G01N33/543 , G01N33/564 , G01N33/577 , G01N33/68 , G01N33/533
Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using cTnI. Also disclosed are methods for determining whether to perform a head computerized tomography on a subject by detecting levels of cTnI. Finally, also disclosed are methods of outcome in subjects suffering from a mild TBI.
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公开(公告)号：US20240426819A1
公开(公告)日：2024-12-26
申请号：US18755023
申请日：2024-06-26
Applicant: NephroSant, Inc.
Inventor： Chih-Hung LAI , Robert ZAWADA , Jeff STOLL , Francsico Dias LOURENCO
IPC: G01N33/543 , G01N21/78 , G01N33/53 , G01N33/68
Abstract: The disclosure provides lateral flow devices for detecting the presence or absence of methylated cIDNA and one or more protein(s) in a biological sample, such as urine or blood.
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公开(公告)号：US20240426817A1
公开(公告)日：2024-12-26
申请号：US18340625
申请日：2023-06-23
Applicant: Zhejiang Orient Gene Biotech Co.,Ltd
Inventor： Siyu LEI , Jianqiu FANG , Hua ZHANG
IPC: G01N33/536 , G01N27/327 , G01N33/543
Abstract: The invention provides a device for testing an analyte in a fluid sample, and the device includes: a housing combined with an upper card and a lower card, where a supporting structure for supporting a lateral flow testing element is arranged on the lower card, the lateral flow testing element is configured to test the analyte in the fluid sample and includes an application pad for receiving a liquid sample, the supporting structure includes a supporting structure for supporting an entire sample application pad, and part of the supporting structure for supporting the sample application pad is inclined.
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40.发明申请
公开(公告)号：US20240418725A1
公开(公告)日：2024-12-19
申请号：US18813645
申请日：2024-08-23
Applicant: Qingdao Sino-Cell Biomedicine Co., Ltd.
Inventor： Zhen Sun , Bin Li , Wenjing Li , Mingming Zhao , Zeyao Wang , Wenna Liu , Qing Gao
IPC: G01N33/574 , G01N15/14 , G01N33/543
Abstract: The present invention relates to a method for detecting and isolating a cell population co-expressing CD45 and EpCAM and the use thereof. In the present invention, a composition or a kit comprising an anti-CD45 antibody and an anti-EpCAM antibody is used for detecting and isolating a cell population co-expressing CD45 and EpCAM from PBMCs, and is used for rapid in-vitro screening of cancer, guiding treatment of cancer, and evaluating the effectiveness of cancer treatment.
