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公开(公告)号：US20160202271A1
公开(公告)日：2016-07-14
申请号：US14655748
申请日：2014-08-20
Inventor： Peng Yue , Jinyuan Zhou , Weiwei Sheng
CPC classification number: G01N33/6893 , G01N21/78 , G01N33/54306 , G01N2021/752 , G01N2021/757 , G01N2021/7759 , G01N2021/7763 , G01N2035/00118 , G01N2333/4713 , G01N2333/76 , G01N2800/042 , G01N2800/347
Abstract: Disclosed is a test paper for detection of diabetic nephropathy, which includes a water-absorbing filter paper, a glass fiber membrane and a NC membrane, all of which are stacked successively from top to bottom. The test paper has a T1 testing region, a T2 testing region and a T3 reference region arranged along a transverse direction; the NC membrane is coated by urinary microalbumin antibodies in the T1 testing region, is coated by urinary haptoglobin antibodies in the T2 testing region and is coated by mouse anti-human IgG antibodies in the T3 reference region; and the glass fiber membrane is coated by urinary microalbumin labeled with colloidal gold in the T1 testing region, is coated by urinary haptoglobin labeled with colloidal gold in the T2 testing region and is coated by mouse anti-human IgG albumen labeled with colloidal gold in the T3 reference region.
Abstract translation: 公开了一种用于检测糖尿病肾病的试纸，其包括吸水滤纸，玻璃纤维膜和NC膜，所有这些都从上到下依次层叠。 测试纸具有沿横向布置的T1测试区域，T2测试区域和T3参考区域; NC膜在T1测试区域用尿微量白蛋白抗体包被，在T2测试区域用尿触珠蛋白抗体包被，并在T3参考区域用小鼠抗人IgG抗体包被; 玻璃纤维膜在T1测试区域用胶体金标记的尿微量白蛋白涂覆，在T2测试区域用胶体金标记的尿触珠蛋白包被，并用胶体金标记的小鼠抗人IgG白蛋白 T3参考区域。
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32.发明授权Progressive compression driven flow cartridge for analyte detecting strip and method 有权用于分析物检测条的逐行压缩驱动流动盒和方法
公开(公告)号：US09377457B1
公开(公告)日：2016-06-28
申请号：US14887179
申请日：2015-10-19
Applicant: Naishu Wang , David F. Zhou
Inventor： Naishu Wang , David F. Zhou
IPC: G01N21/75 , G01N33/543 , G01N21/78 , G01N33/558 , G01N21/77
CPC classification number: G01N33/54386 , G01N21/78 , G01N21/8483 , G01N33/558 , G01N33/56983 , G01N2021/7759
Abstract: A cartridge and method for conducting a labeled molecular affinity binding test such as antibody/antigen, ligand/receptor, and colorometric reactions, and other chemical reactions for which one or more analytes is present in a liquid sample formate. A progressive compression structure progressively forces a liquid flow out of a conjugate pad toward a reaction region to more thoroughly and rapidly mix the liquid, encouraging specific first affinity binding to the analytes in question. A specially dimensioned constricting passageway surrounding the reaction region including the result zones provides an additional siphoning force to the flow. These combined forces rapidly and more evenly guide the flow of liquid through the reaction region so that the rushed rate of uptake of analytes at the strip lines are more evenly distributed, adhesive attachment of non-specific molecules is largely avoided, vastly improving sensitivity and specificity, and providing quantitative results in some tests.
Abstract translation: 用于进行标记的分子亲和力结合试验例如抗体/抗原，配体/受体和着色反应的药筒和方法以及其中一种或多种分析物存在于液体样品甲酸盐中的其它化学反应。 渐进的压缩结构逐渐迫使液体流出共轭垫朝向反应区域，以更彻底和快速地混合液体，鼓励与所讨论的分析物的特异性第一亲和力结合。 围绕包括结果区域的反应区域的特别尺寸的收缩通道向流动提供额外的虹吸力。 这些组合力迅速且均匀地引导液体流过反应区域，使得剥离线处的分析物的冲洗速率更均匀分布，很大程度上避免了非特异性分子的粘附性附着，大大提高了敏感性和特异性 ，并在一些测试中提供定量结果。
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公开(公告)号：US20160146714A1
公开(公告)日：2016-05-26
申请号：US14549055
申请日：2014-11-20
Inventor： Keith A. Oberg , Mark D. Dobbs , Ekaterina Tkatchouk , Scott P. Layne , Milton Lee
CPC classification number: C08J9/286 , B01L3/5023 , B01L2200/12 , B01L2200/147 , B01L2300/0825 , B01L2300/161 , C08J2333/06 , C08J2333/08 , C08J2333/10 , C08J2333/14 , C08J2335/02 , C12Q1/6813 , C12Q1/6844 , G01N1/28 , G01N21/49 , G01N21/59 , G01N21/77 , G01N2021/495 , G01N2021/7759 , G01N2021/7786
Abstract: Described herein are monoliths for processing fluid samples, and methods of making and using such monoliths.
Abstract translation: 这里描述的是用于处理流体样品的整料，以及制造和使用这种整料的方法。
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公开(公告)号：US09329159B2
公开(公告)日：2016-05-03
申请号：US13789935
申请日：2013-03-08
Applicant: Ecolab USA Inc.
Inventor： Robert S Walicki
CPC classification number: G01N21/78 , G01N21/8483 , G01N31/22 , G01N33/18 , G01N2021/752 , G01N2021/7759
Abstract: Methods and systems for colorimetrically analyzing a liquid medium by analyzing chemical test strip images are provided. The liquid medium can be industrial water in an industrial water system. Image analyzing software carries out the analysis. The results of the analysis can be used to diagnosing a chemical treatment regimen of the industrial water system. A chemical test strip holder can be used to enhance reliability and repeatability of the imaging process and/or subsequent analysis.
Abstract translation: 提供了通过分析化学测试条图像对液体介质进行比色分析的方法和系统。 液体介质可以是工业用水系统中的工业用水。 图像分析软件进行分析。 分析结果可用于诊断工业用水系统的化学处理方案。 可以使用化学测试条支架来增强成像过程的可靠性和重复性和/或随后的分析。
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35.发明申请Laminated Detector for Detection and Quantitative Determination of Formaldehyde 审中-公开用于甲醛检测和定量测定的层压检测器
公开(公告)号：US20160077013A1
公开(公告)日：2016-03-17
申请号：US14059041
申请日：2013-10-21
Applicant: Amir James Attar , Matthew David Swartz , Jason Allen Morton
Inventor： Amir James Attar , Matthew David Swartz , Jason Allen Morton
CPC classification number: G01N31/22 , G01N2021/7759
Abstract: A multi-layered laminated test strip detector for formaldehyde is described which simplifies significantly the qualitative detection and quantitative determination of formaldehyde in aqueous solution or on the surface of wet solids. Layers of water soluble polymer are used to separate chemical reagents that otherwise will not be stable, and/or encapsulate the chemical reagents on bibulous material. Introducing the sample or wetting the detector through holes in a laminated encapsulating envelope permits the aqueous sample to dissolve the solid barrier when the sample is introduced and contact the reagents and the analyte, thereby forming color on the back side of the detector.
Abstract translation: 描述了用于甲醛的多层层压测试条检测器，其显着地简化了在水溶液中或在固体表面上的甲醛的定性检测和定量测定。 使用水溶性聚合物层分离否则不稳定的化学试剂和/或将化学试剂包封在吸水材料上。 引入样品或通过层叠封装外壳中的孔润湿检测器，允许水样品在引入样品时溶解固体屏障，并接触试剂和分析物，从而在检测器背面形成颜色。
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公开(公告)号：US20160054229A1
公开(公告)日：2016-02-25
申请号：US14825876
申请日：2015-08-13
Applicant: Xerox Corporation
Inventor： Nancy Y. Jia , Mandakini Kanungo , Wei Hong , Jing Zhou
CPC classification number: G01N21/253 , G01N21/251 , G01N21/78 , G01N21/8483 , G01N2021/7759 , G06F19/00 , G16H10/60
Abstract: This disclosure provides a workflow method and system associated with a paper-based sensor. Specifically, provided is a paper-based sensor workflow including printing of customized security sensing information and bio-reagents to produce a paper-based sensor, applying a test material, such as, but not limited to, blood, to the paper-based sensor, capturing an image of the paper-based sensor and performing a colorimetric process; and performing one or more analytics to produce results associated with the test material
Abstract translation: 本公开提供了与纸基传感器相关联的工作流方法和系统。 具体来说，提供了一种基于纸的传感器工作流程，包括定制的安全感测信息的印刷和生物试剂以生产基于纸的传感器，将测试材料（例如但不限于血液）应用于纸基传感器 捕获基于纸的传感器的图像并执行比色处理; 并执行一个或多个分析以产生与测试材料相关联的结果
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37.发明申请Method for Detection of Legionella Bacteria Employing Purified Antigen-Specific Antibodies 有权检测使用纯化抗原特异性抗体的军团菌细菌的方法
公开(公告)号：US20160047807A1
公开(公告)日：2016-02-18
申请号：US14828823
申请日：2015-08-18
Applicant: Alere Scarborough, Inc.
Inventor： Vladimir A. Koulchin , Norman J. Moore , Elena V. Molokova
IPC: G01N33/569 , G01N21/78
CPC classification number: G01N33/56911 , C07K16/126 , G01N21/78 , G01N33/53 , G01N2021/752 , G01N2021/757 , G01N2021/7759 , G01N2400/10 , G01N2469/10
Abstract: The present invention involves extracting from Legionella bacteria, particularly L. pneumophila bacteria, an essentially protein-free O-polysaccharide or carbohydrate antigen, coupling this antigen to an activated chromatographic column through a protein space molecule which is first conjugated to the antigen, utilizing the column thus prepared for the affinity purification of raw polyvalent antibodies to the same Legionella bacterium from which the O-polysaccharide or carbohydrate antigen was separated—thereby obtaining antigen-specific antibodies which are useful for the rapid detection of the corresponding Legionella bacterium or its antibody in human bodily fluids such as urine, sputum, blood and the like or in environmental samples suspected of harboring theLegionella bacterium.
Abstract translation: 本发明涉及从军团菌细菌，特别是嗜肺链球菌细菌，一种基本上无蛋白的O-多糖或碳水化合物抗原提取，该抗原通过首先与抗原缀合的蛋白质空间分子将该抗原与活化的色谱柱偶联， 将这样制备的原料多价抗体亲和纯化到与其分离O-多糖或碳水化合物抗原的相同军团杆菌细菌中，从而获得可用于快速检测相应的军团菌或其抗体的抗原特异性抗体 人体液体如尿液，痰液，血液等，或涉嫌怀疑含有白血病细菌的环境样品。
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公开(公告)号：US20150367149A1
公开(公告)日：2015-12-24
申请号：US14748163
申请日：2015-06-23
Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services , The Regents of the University of California
Inventor： Lee A. Greenawald , Gerry R. Boss , Nicole Fry , Michael J. Sailor , Matthew Brenner , Sari B. Mahon
CPC classification number: A62B9/006 , A62B19/00 , G01N21/783 , G01N2021/7759 , G01N2021/7773 , G01N2021/7783
Abstract: This disclosure concerns materials for detecting and removing gaseous chemical agents (e.g., cyanide, cyanogen, sulfide, nitrite, nitric oxide, and combinations thereof), devices including the materials, and methods of making and using the disclosed materials. Embodiments of the disclosed materials include a support material impregnated with cobinamide and/or a cobinamide derivative.
Abstract translation: 本公开涉及用于检测和去除气体化学试剂（例如氰化物，氰，硫化物，亚硝酸盐，一氧化氮及其组合）的材料，包括材料的装置以及制造和使用所公开的材料的方法。 所公开的材料的实施方案包括用共混酰胺和/或共混酰胺衍生物浸渍的载体材料。
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公开(公告)号：US20150285778A1
公开(公告)日：2015-10-08
申请号：US14441781
申请日：2013-11-12
Applicant: HACH COMPANY
Inventor： Matthew P. Hertel , David A.N. Morris
CPC classification number: G01N33/18 , G01N21/293 , G01N21/78 , G01N21/80 , G01N21/8483 , G01N31/22 , G01N2021/7759 , G01N2021/7793 , G01N2021/8488
Abstract: A species test wand for liquids, wherein a user is informed whether the concentration of a species is high, at an acceptable level, or low by a comparison of the color of the wand after exposure to the liquid with nearby labeled colored boxes integral with the wand, is described. Tests include liquid evaluation for chlorine, pH and total alkalinity, as examples.
Abstract translation: 用于液体的物种测试棒，其中通过在暴露于液体之后比较鞭子的颜色，附近标记的彩色盒子与 魔杖被描述。 测试包括对氯，pH和总碱度的液体评估，例如。
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公开(公告)号：US20120149093A1
公开(公告)日：2012-06-14
申请号：US13287306
申请日：2011-11-02
Applicant: Jason Gould , Martin Gould , Susan Gould
Inventor： Jason Gould , Martin Gould , Susan Gould
CPC classification number: B01L3/5023 , B01L2300/0654 , B01L2300/0816 , B01L2300/0825 , B01L2400/0406 , B01L2400/0672 , G01N21/78 , G01N31/22 , G01N2021/7759
Abstract: A device which collects specimen fluids or performs chemical or biological assays of the specimen fluid is provided with a specimen fluid receiver and a fluid actuated expandable trigger coupled to receive specimen fluid from the specimen fluid receiver such that a predetermined delay occurs before the trigger expands sufficiently to move another component of the device, and the specimen fluid interacts with a substance during the delay. The trigger is made of a material which expands substantially upon absorbing specimen fluid, and it is mounted and positioned so as to contact and move the other component of the device upon expanding through the absorption of specimen fluid. The other component may contain a surface coupled to receive specimen fluid from the specimen fluid receiver and the surface has an area which contains a substance which interacts with the specimen fluid.
Abstract translation: 收集样品流体或进行样品流体的化学或生物测定的装置设置有样品流体接收器和流体致动的可膨胀触发器，其被耦合以从样品流体接收器接收样本流体，使得在触发器充分膨胀之前发生预定的延迟 以移动装置的另一部件，并且在延迟期间样品流体与物质相互作用。 触发器由在吸收样本流体时基本膨胀的材料制成，并且其被安装和定位以便在通过吸收样品流体膨胀时接触并移动该装置的另一个部件。 另一个组件可以包含耦合以从样品流体接收器接收样本流体的表面，并且表面具有包含与样品流体相互作用的物质的区域。
