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公开(公告)号：US20050075546A1
公开(公告)日：2005-04-07
申请号：US10943737
申请日：2004-09-17
Applicant: James Samsoondar , Duncan MacIntyre , Ashwani Kaushal
Inventor： James Samsoondar , Duncan MacIntyre , Ashwani Kaushal
CPC classification number: A61B5/0059 , A61B2562/0238
Abstract: The present invention provides an apparatus and a method for identifying the risk of a clinical condition in a human or animal by correlating Near Infrared (NIR) absorbance spectral data with one or several parameters including a concentration of one or more substances in the skin, a concentration of one or more substances in skin plus subdermal tissue, a score derived from one or more clinical tests like a stress test on a treadmill, coronary angiography, or intravascular coronary ultrasound. The method determines the concentration of a compound in the skin of a human or animal and comprises the steps of placing a part of the skin against a receptor, directing electromagnetic radiation (EMR) from the near-infrared spectrum onto the skin, measuring a quantity of EMR reflected by, or transmitted through, the skin with a detector; and performing a quantitative mathematical analysis of the quantity of EMR to determine the concentration of the compound, for example free and esterfied cholesterol. An example of a clinical condition is cardiovascular disease.
Abstract translation: 本发明提供了一种用于通过将近红外（NIR）吸收光谱数据与包括皮肤中的一种或多种物质的浓度的一个或几个参数相关联来鉴定人或动物的临床状况的风险的装置和方法， 皮肤中的一种或多种物质和皮下组织的浓度，来自一项或多项临床试验的得分，如跑步机上的压力试验，冠状动脉造影或血管内冠状动脉超声。 该方法确定化合物在人或动物皮肤中的浓度，包括以下步骤：将一部分皮肤放置在受体上，将电磁辐射（EMR）从近红外光谱引导到皮肤上，测量数量 由检测器反射或透过皮肤的EMR; 并对EMR的量进行定量数学分析以确定化合物的浓度，例如游离和酯化的胆固醇。 临床病症的一个例子是心血管疾病。
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公开(公告)号：US20050037505A1
公开(公告)日：2005-02-17
申请号：US10823778
申请日：2004-04-14
Applicant: James Samsoondar
Inventor： James Samsoondar
IPC: G01N33/483 , B01L3/00 , G01N21/03 , G01N21/27 , G01N21/31 , G01N21/33 , G01N21/35 , G01N33/48 , G01N33/72 , G01N33/20
CPC classification number: B01L3/508 , B01L2200/0605 , B01L2300/043 , B01L2300/0809 , G01N21/03 , G01N21/274 , G01N21/31 , G01N33/72
Abstract: An apparatus and method for spectroscopic measurement of an analyte in a sample is provided. The apparatus comprises a source of electromagnetic radiation (EMR) producing a light path, an aperture located within the light path and between the EMR source and a sample slot, and a photodector. The apparatus also has a primary calibration algorithm that is in operative association with the spectroscopic apparatus. Examples of analytes that may be measured using this apparatus include, but are not limited to Total-Hemoglobin, Met-Hemoglobin, Hemoglobin-based blood substitutes and any Met-Hemoglobin equivalent. The measurement of Met-Hemoglobin may be used to provide an accurate measurement of Total-Hemoglobin in whole blood, or Hemoglobin when used as an indicator of hemolysis. The measurement of Met-Hemoglobin may also be also used as a means of monitoring the degradation or reversal of degradation of Hemoglobin-based blood substitutes, or as a means of monitoring the oxidation or reversal of oxidation of Hemoglobin to Met-Hemoglobin.
Abstract translation: 提供了用于样品中分析物的光谱测量的装置和方法。 该装置包括产生光路的电磁辐射源（EMR），位于光路内以及EMR源与样本槽之间的孔以及光电二极管。 该装置还具有与分光装置操作关联的主校准算法。 可以使用该装置测量的分析物的实例包括但不限于全血红蛋白，血红蛋白，基于血红蛋白的血液代用品和任何Met-血红蛋白当量。 Met-Hemoglobin的测量可用于提供全血中血红蛋白总量的准确测量，或用作溶血指标时的血红蛋白。 Met-Hemoglobin的测量也可以用作监测血红蛋白基血液代用品降解或逆转的手段，或者作为监测血红蛋白氧化或逆转成血红蛋白的手段。
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公开(公告)号：US06841132B2
公开(公告)日：2005-01-11
申请号：US10042258
申请日：2002-01-11
Applicant: James Samsoondar
Inventor： James Samsoondar
CPC classification number: B01L3/508 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150343 , A61B5/150351 , B01L2300/043 , B01L2300/0809 , G01N21/03 , G01N21/314 , G01N33/721 , G01N33/726
Abstract: A sample lab for retaining a sample during spectrophorometric analysis includes a base plate, a sample well, and a cover plate. The sample tab may also include one, or more than one overflow opening for draining excess sample, and an overflow channel to retain the excess sample.
Abstract translation: 用于在分光光度法分析过程中保留样品的样品实验室包括底板，样品孔和盖板。 样品片还可以包括用于排出多余样品的一个或多于一个的溢流开口和用于保留多余样品的溢流通道。
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公开(公告)号：US06582964B1
公开(公告)日：2003-06-24
申请号：US09958933
申请日：2002-01-23
Applicant: James Samsoondar , Romuald Pawluczyk , Petersen Borge , Theordore E. Cadell , Bernard Zinman , Bronislaw Bednarz
Inventor： James Samsoondar , Romuald Pawluczyk , Petersen Borge , Theordore E. Cadell , Bernard Zinman , Bronislaw Bednarz
IPC: G01N3372
CPC classification number: B01L3/508 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150343 , A61B5/150351 , B01L2300/043 , B01L2300/0809 , G01N21/03 , G01N21/314 , G01N33/721 , G01N33/726
Abstract: Described is a method and apparatus for determining a diabetic patient's compliance with their insulin dosing regime. The method and apparatus involves taking a blood sample from a patient by a routine finger prick and placing it in a special sample tab which is placed in a spectrophotometer sample housing. The spectrophotometer measures Hb and HbA1c concentrations and allows for calculating a ratio of HbA1c to Hb which is indicative of the degree of patient compliance.
Abstract translation: 描述了一种用于确定糖尿病患者对其胰岛素给药方案的依从性的方法和装置。 该方法和装置包括通过常规手指刺从患者取血样并将其放置在放置在分光光度计样品壳体中的特殊样品片中。 分光光度计测量Hb和HbA1c浓度，并允许计算HbA1c与Hb的比值，表示患者依从程度。
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35.发明授权Method and apparatus for screening plasma for interferents in plasma from donor blood bags 有权用于筛选来自供体血袋的血浆中干扰物的血浆的方法和装置
公开(公告)号：US06268910B1
公开(公告)日：2001-07-31
申请号：US09367863
申请日：1999-09-03
Applicant: James Samsoondar , Douglas George Given
Inventor： James Samsoondar , Douglas George Given
IPC: G01N3348
CPC classification number: G01N21/314 , A61M1/0236 , G01N21/359
Abstract: An apparatus and a method whereby plasma integrity of plasma contained in a blood bag is rapidly and accurately assessed without compromising the sterility of the plasma, or destroying any of its components. This is achieved through spectral data which is used in a novel way so as to determine if a plasma specimen representative of plasma in a blood bag contains interferents and if so, to what extent. The apparatus and method analyse plasma contained in two bags whereby tubing connects the two bags. A lamp is used to irradiate the specimen, and a spectrophotometer is used to measure radiation from the specimen. The apparatus and method allow for determination where both the bags and tubings are translucent and contain writing on their surfaces (e.g., proprietary information), and the light is transmitted through the writings, plastic, and the plasma contained in the bag or tubing.
Abstract translation: 包含在血袋中的等离子体完整性的装置和方法能够快速而准确地评估，而不损害等离子体的无菌性或破坏血浆中的任何组分。 这通过以新颖的方式使用的光谱数据来实现，以便确定代表血袋中的血浆的血浆样本是否包含干扰物，如果是，则在多大程度上。 该装置和方法分析包含在两个袋中的等离子体，由此管连接两个袋。 使用灯来照射样品，并使用分光光度计来测量样品的辐射。 该装置和方法允许确定袋和管两者是否是半透明的并且在其表面上包含书写（例如，专有信息），并且光通过包含在袋或管中的书写，塑料和等离子体传输。
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公开(公告)号：US06013528A
公开(公告)日：2000-01-11
申请号：US115366
申请日：1998-07-14
Applicant: Merrit Nyles Jacobs , Davis Freeman, III , James David Shaw , James Samsoondar , Thomas Moffett
Inventor： Merrit Nyles Jacobs , Davis Freeman, III , James David Shaw , James Samsoondar , Thomas Moffett
CPC classification number: G01N21/359 , G01N21/03 , G01N21/11 , G01N21/13 , G01N2035/0432 , G01N2035/0434 , Y10T436/112499 , Y10T436/119163 , Y10T436/2575
Abstract: Apparatus and method for detecting patient sample quality, and/or analytes, in the tip used to aspirate the patient sample liquid and then dispense it onto a slide test element. Spectrophotometric analysis is done on the liquid while still in the tip, by scanning the tip for transmittance in a light-tight enclosure, using NIR and adjacent visible radiation, and detecting the absorbance spectra of the liquid. Thereafter, or prior thereto, the liquid is dispensed onto a dried slide test element for assaying analytes that are not assayed spectrophotometrically, thus enhancing throughput.
Abstract translation: 用于检测患者样品质量的装置和方法，和/或分析物，用于抽吸患者样品液体的尖端，然后将其分配到载玻片测试元件上。 通过使用NIR和相邻的可见光辐射扫描尖端以在不透光的外壳中进行透射，并检测液体的吸收光谱，对液体进行分光光度分析。 此后，或之前，将液体分配到干燥的载玻片测试元件上，用于测定未通过分光光度法测定的分析物，从而提高产量。
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公开(公告)号：US20170144146A1
公开(公告)日：2017-05-25
申请号：US15356630
申请日：2016-11-20
Applicant: James Samsoondar
Inventor： James Samsoondar
CPC classification number: B01L3/502 , B01L2200/025 , B01L2200/026 , B01L2200/0605 , B01L2200/0684 , B01L2300/042 , B01L2300/043 , B01L2300/046 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N33/49 , G01N33/86
Abstract: Some embodiments of the invention provide a disposable cartridge for rapidly metering a sample for measuring a property of the sample. The cartridge can receive a sample when it is in an unsealed configuration, and a cap is used to facilitate metering of the sample and sealing the cartridge. When the cartridge is in a sealed configuration, pressurised air is used to push the metered sample into a chamber containing at least one reagent, and subsequently into a detection chamber for measuring the property of the sample.
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公开(公告)号：US09162186B2
公开(公告)日：2015-10-20
申请号：US13549443
申请日：2012-07-14
Applicant: James Samsoondar
Inventor： James Samsoondar
IPC: B01D63/02
CPC classification number: B01D63/02 , B01D2313/16 , B01D2313/18 , B01D2313/24
Abstract: The present invention provides a filtration assembly in the form of a disposable cartridge. A key feature of the invention is a filtration chamber having a porous membrane also referred to as a filter, a sample inlet to the filtration chamber, and an outlet for outflow of the fraction of sample that does not penetrate the membrane. The membrane can be used in any configuration, for example a hollow fiber. The fraction of sample that penetrates the membrane is referred to as the filtrate, and the fraction that does not penetrate the membrane is referred to as the retentate or concentrate. Some uses of the cartridge are to prepare plasma from blood, and to prepare a plasma ultra-filtrate from plasma, without the need for centrifugation. Many therapeutic drugs are highly protein bound, and a plasma ultra-filtrate is sometimes required to measure the unbound biologically active drugs.
Abstract translation: 本发明提供一种过滤组件，其形式为一次性药筒。 本发明的一个关键特征是具有多孔膜的过滤室，也称为过滤器，过滤室的样品入口以及不渗透膜的样品部分的流出出口。 膜可以以任何构造使用，例如中空纤维。 将渗透膜的样品的部分称为滤液，将不渗透膜的部分称为滞留物或浓缩物。 墨盒的一些用途是从血液制备血浆，并从血浆制备血浆超滤液，而不需要离心。 许多治疗药物是高蛋白结合的，有时需要血浆超滤液来测量未结合的生物活性药物。
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公开(公告)号：US07807450B2
公开(公告)日：2010-10-05
申请号：US11835631
申请日：2007-08-08
Applicant: James Samsoondar
Inventor： James Samsoondar
IPC: C12M3/00
CPC classification number: A61B5/14546 , A61B5/14557 , A61B5/150022 , A61B5/15003 , A61B5/150213 , A61B5/150236 , A61B5/150244 , A61B5/150251 , A61B5/150343 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992
Abstract: A system that is suitable for extracting plasma from blood received from a blood supply is provided. The system comprises a housing, an inlet opening for receiving the blood, a filtration chamber comprising a membrane, and a plasma compartment. The membrane forms a barrier between the blood and the plasma extracted from the blood, and the plasma compartment collects the plasma extracted from the blood. In some embodiments, the system comprises a plasma flow path compression chamber for pulling plasma across the membrane. In some embodiments, the system comprises a blood flow path compression chamber for facilitating blood flow. Some embodiments of the system further comprise means for measuring plasma and blood analytes using spectroscopic and biosensor techniques.
Abstract translation: 提供一种适合于从血液供应的血液中提取血浆的系统。 该系统包括壳体，用于接收血液的入口开口，包括膜的过滤室和等离子体室。 所述膜在血液和从血液中提取的血浆之间形成屏障，血浆室收集从血液中提取的血浆。 在一些实施例中，该系统包括用于在膜上拉动等离子体的等离子体流动路径压缩室。 在一些实施例中，该系统包括用于促进血液流动的血流通道压缩室。 该系统的一些实施例还包括使用光谱和生物传感器技术来测量血浆和血液分析物的装置。
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公开(公告)号：US20080097243A1
公开(公告)日：2008-04-24
申请号：US11466588
申请日：2006-08-23
Applicant: James Samsoondar
Inventor： James Samsoondar
CPC classification number: A61B5/150603 , A61B5/15003 , A61B5/150213 , A61B5/150251 , A61B5/150389 , A61B5/150503 , A61B5/150633 , A61B5/150717 , A61B5/153 , A61M5/326 , A61M5/3271
Abstract: Some embodiments of the invention provide a needle with a sharp open end and a blunt open end, housed in a barrel with an open anterior end and an open posterior end. The barrel can travel along the hub of the needle, for extending the needle for insertion into a blood vessel, and for retracting the needle into the barrel to avoid injury. The blunt open end can be fluidly connected to the inlet opening of a measurement apparatus, so that the blood can flow directly into the measurement apparatus, eliminating the traditional step of transferring the blood from a syringe to the measurement apparatus. The hollow needle assembly can remain attached to the measurement apparatus because of its small size, and the engagement of an optional safety cap to the open anterior end of the barrel, minimizes the risk of injury and blood contamination. Because a small blood sample is required, a very small needle shaft can be used, minimizing the discomfort experienced by the patient.
Abstract translation: 本发明的一些实施例提供了一种具有尖锐的开口端和平坦的开口端的针，其容纳在具有开放的前端和敞开的后端的筒中。 枪管可以沿着针的轮毂行进，用于将针插入血管中，并将针回收到枪管中以避免伤害。 平坦的开口端可以流体地连接到测量装置的入口，使得血液可以直接流入测量装置，消除了将血液从注射器转移到测量装置的传统步骤。 中空针组件由于其尺寸小而可以保持附接到测量装置，并且可选安全帽与筒的敞开的前端的接合使得受伤和血液污染的风险最小化。 因为需要小血液样本，所以可以使用非常小的针轴，从而最小化患者经历的不适。
