公开(公告)号：US20020065302A1

公开(公告)日：2002-05-30

申请号：US10016910

申请日：2001-12-14

申请人： ICOS Corporation

发明人： Kerry W. Fowler ,  Amy Oliver ,  Joshua Odingo

IPC分类号： C07D47/14 ,  C07D41/02 ,  A61K031/454 ,  A61K031/4025 ,  A61K031/40

CPC分类号： C07D207/09

摘要： Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.