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公开(公告)号：US20050288323A1
公开(公告)日：2005-12-29
申请号：US11205958
申请日：2005-08-17
Applicant: Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
Inventor： Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
IPC: A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/00 , A61K49/00 , A61K51/04 , A61P1/08 , A61P1/14 , A61P11/02 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P37/08 , A61P43/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07D487/04 , A61K31/4745
CPC classification number: C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
Abstract translation: 本发明具有取代的稠合双环化合物，含有它们的药物组合物，以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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22.发明申请Pyridone compounds as inhibitors of bacterial type III protien secreation systems 失效吡啶酮化合物作为细菌III型protien分泌系统的抑制剂
公开(公告)号：US20050256137A1
公开(公告)日：2005-11-17
申请号：US11123995
申请日：2005-05-06
Applicant: Xiaobing Li
Inventor： Xiaobing Li
IPC: A61K31/44 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/506 , C07D211/84 , C07D213/75 , C07D401/04 , C07D405/04 , C07D407/04 , C07D409/04
CPC classification number: C07D213/75 , C07D401/04 , C07D405/04 , C07D407/04 , C07D409/04
Abstract: In accordance with the present invention, compounds that inhibit Type III protein section have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein section and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制III型蛋白质区段的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制III型蛋白质区段和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的方法。
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23.发明申请Triazine compounds as inhibitors of bacterial type III protein secretion systems 审中-公开三嗪化合物作为细菌III型蛋白分泌系统的抑制剂
公开(公告)号：US20050250945A1
公开(公告)日：2005-11-10
申请号：US11124009
申请日：2005-05-06
Applicant: Xiaobing Li , Fu-An Kang , Mark Macielag
Inventor： Xiaobing Li , Fu-An Kang , Mark Macielag
IPC: C07D251/18 , C07D401/04 , C07D401/12 , C07D405/04 , C07D43/02
CPC classification number: C07D401/12 , C07D251/18 , C07D401/04 , C07D405/04
Abstract: In accordance with the present invention, compounds that inhibit Type III protein section have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein section and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制III型蛋白质区段的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制III型蛋白质区段和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的方法。
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公开(公告)号：US20050043348A1
公开(公告)日：2005-02-24
申请号：US10960248
申请日：2004-10-07
Applicant: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
Inventor： J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC classification number: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号：US07881754B2
公开(公告)日：2011-02-01
申请号：US12007664
申请日：2008-01-14
Applicant: Masanori Honda , Takayuki Hayashi , Hiroki Ishii , Xiaobing Li
Inventor： Masanori Honda , Takayuki Hayashi , Hiroki Ishii , Xiaobing Li
CPC classification number: H04M1/72586 , H04M1/0214 , H04M1/72522 , H04M1/72583 , H04M2250/16
Abstract: There is provided a portable communication terminal capable of switching between icon display and non-display. Processes executed by a control unit of a portable phone which is an aspect of the portable communication terminal comprises the steps of detecting, during the execution of an icon-bar displaying process, a press of an operation key, terminating outputting icon data if the operation key is associated with the icon-bar non-display function and if there is already no icon bar being displayed, detecting a press of the operation key, and executing the icon-bar displaying process if the operation key is associated with the icon-bar display function and if there is no icon bar being displayed.
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公开(公告)号：US20090263322A1
公开(公告)日：2009-10-22
申请号：US12494754
申请日：2009-06-30
Applicant: Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
Inventor： Richard Apodaca , Nicholas I. Carruthers , John R. Carson , Wenying Chai , Annette K. Kwok , Xiaobing Li , Timothy W. Lovenberg , Dale A. Rudolph , Chandravadan R. Shah
IPC: A61K31/437 , C07D221/04 , C07D401/14 , A61K31/496 , A61K51/00 , A61P11/00 , A61P25/00
CPC classification number: C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
Abstract translation: 本发明具有取代的稠合双环化合物，含有它们的药物组合物，以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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公开(公告)号：US07041828B2
公开(公告)日：2006-05-09
申请号：US10960363
申请日：2004-10-07
Applicant: J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
Inventor： J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
IPC: C07D47/04
CPC classification number: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号：US07041827B2
公开(公告)日：2006-05-09
申请号：US10960200
申请日：2004-10-07
Applicant: J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
Inventor： J. Guy Breitenbucher , Nicholas I. Carruthers , Xiaobing Li , Laura C. McAtee , Chandravadan R. Shah , Ronald L. Wolin
IPC: C07D471/04
CPC classification number: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号：US20050272784A1
公开(公告)日：2005-12-08
申请号：US11123977
申请日：2005-05-06
Applicant: Xiaobing Li , William Murray , Mark Macielag , Qunying Guan
Inventor： Xiaobing Li , William Murray , Mark Macielag , Qunying Guan
IPC: A61K31/421 , A61K31/4245 , A61P31/04 , C07D231/14 , C07D233/90 , C07D249/10 , C07D263/34 , C07D277/56 , C07D413/02 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10
CPC classification number: C07D263/34 , C07D231/14 , C07D233/90 , C07D249/10 , C07D277/56 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10
Abstract: In accordance with the present invention, compounds that inhibit Type III protein secretion have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein secretion and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制III型蛋白质分泌的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的方法。
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公开(公告)号：US20050250819A1
公开(公告)日：2005-11-10
申请号：US11124008
申请日：2005-05-06
Applicant: Xiaobing Li , Mark Macielag
Inventor： Xiaobing Li , Mark Macielag
IPC: A61K31/16 , C07C235/78 , C07C237/22 , C07C275/24 , C07D207/22 , C07D209/42 , C07D211/72 , C07D307/14 , C07D307/54 , C07D307/85 , C07D333/24 , C07D333/68 , C07D401/04 , C07K5/06
CPC classification number: C07C323/25 , C07C235/78 , C07C237/22 , C07C275/10 , C07C275/24 , C07C281/06 , C07C323/59 , C07D209/42 , C07D307/14 , C07D307/54 , C07D307/85 , C07D333/24 , C07D333/68 , C07D401/04 , C07K5/06078 , C07K5/06191
Abstract: In accordance with the present invention, compounds that inhibit Type III protein section have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein section and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention.
Abstract translation: 根据本发明，已经鉴定了抑制III型蛋白质区段的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制III型蛋白质区段和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的方法。
