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公开(公告)号：US10754994B2
公开(公告)日：2020-08-25
申请号：US16415960
申请日：2019-05-17
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： Bill James Peck
Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Additionally, devices described herein for de novo synthesis of nucleic acids encoding information related to the original source information may be rigid or flexible material. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Also provided herein are methods and systems for efficient transfer of preselected polynucleotides from a storage structure for reading stored information.
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公开(公告)号：US10417457B2
公开(公告)日：2019-09-17
申请号：US15709274
申请日：2017-09-19
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： Bill James Peck
Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Additionally, devices described herein for de novo synthesis of nucleic acids encoding information related to the original source information may be rigid or flexible material. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Also provided herein are methods and systems for efficient transfer of preselected polynucleotides from a storage structure for reading stored information.
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公开(公告)号：US10384188B2
公开(公告)日：2019-08-20
申请号：US15377547
申请日：2016-12-13
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: B01L3/00 , B01J19/00 , C12N15/10 , C40B50/18 , C12N15/66 , C12N15/74 , C40B50/00 , C40B40/06 , C40B50/14 , C12N15/09
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US09889423B2
公开(公告)日：2018-02-13
申请号：US15245054
申请日：2016-08-23
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US09555388B2
公开(公告)日：2017-01-31
申请号：US15187721
申请日：2016-06-20
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
Abstract translation: 本文提供了从头合成的大型核酸文库，其错误率低。 此外，本文描述了用于制造高质量构建块（例如寡核苷酸）的装置。 可以使用微流控组件并行合成更长的核酸。 此外，本文的方法允许快速构建长，高质量基因的大型文库。 用于制造长质量和高质量核酸的大型文库的装置在本文中进一步描述。
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公开(公告)号：US11562103B2
公开(公告)日：2023-01-24
申请号：US17578356
申请日：2022-01-18
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： Bill James Peck
Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Additionally, devices described herein for de novo synthesis of nucleic acids encoding information related to the original source information may be rigid or flexible material. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Also provided herein are methods and systems for efficient transfer of preselected polynucleotides from a storage structure for reading stored information.
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公开(公告)号：US11550939B2
公开(公告)日：2023-01-10
申请号：US15902855
申请日：2018-02-22
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： Bill James Peck , Ramsey Ibrahim Zeitoun
Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.
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公开(公告)号：US11452980B2
公开(公告)日：2022-09-27
申请号：US16737401
申请日：2020-01-08
Applicant: Twist Bioscience Corporation
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: C12N15/10 , C40B50/18 , C12N15/66 , C12N15/74 , C40B50/00 , C40B40/06 , C40B50/14 , C12N15/09 , B01J19/00
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US10773232B2
公开(公告)日：2020-09-15
申请号：US16535779
申请日：2019-08-08
Applicant: Twist Bioscience Corporation
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: B01J19/00 , C12N15/10 , C40B50/18 , C40B50/00 , C40B50/14 , C12N15/66 , C12N15/74 , C40B40/06 , C12N15/09
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US10744477B2
公开(公告)日：2020-08-18
申请号：US15960319
申请日：2018-04-23
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle , Eugene P. Marsh
Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.
