Video capturing device for predicting special driving situations

    公开(公告)号:US10296796B2

    公开(公告)日:2019-05-21

    申请号:US15478886

    申请日:2017-04-04

    Abstract: A video device for predicting driving situations while a person drives a car is presented. The video device includes multi-modal sensors and knowledge data for extracting feature maps, a deep neural network trained with training data to recognize real-time traffic scenes (TSs) from a viewpoint of the car, and a user interface (UI) for displaying the real-time TSs. The real-time TSs are compared to predetermined TSs to predict the driving situations. The video device can be a video camera. The video camera can be mounted to a windshield of the car. Alternatively, the video camera can be incorporated into the dashboard or console area of the car. The video camera can calculate speed, velocity, type, and/or position information related to other cars within the real-time TS. The video camera can also include warning indicators, such as light emitting diodes (LEDs) that emit different colors for the different driving situations.

    T-CELL RECEPTOR REPERTOIRE SELECTION PREDICTION WITH PHYSICAL MODEL AUGMENTED PSEUDO-LABELING

    公开(公告)号:US20230129568A1

    公开(公告)日:2023-04-27

    申请号:US17969883

    申请日:2022-10-20

    Abstract: Systems and methods for predicting T-Cell receptor (TCR)-peptide interaction, including training a deep learning model for the prediction of TCR-peptide interaction by determining a multiple sequence alignment (MSA) for TCR-peptide pair sequences from a dataset of TCR-peptide pair sequences using a sequence analyzer, building TCR structures and peptide structures using the MSA and corresponding structures from a Protein Data Bank (PDB) using a MODELLER, and generating an extended TCR-peptide training dataset based on docking energy scores determined by docking peptides to TCRs using physical modeling based on the TCR structures and peptide structures built using the MODELLER. TCR-peptide pairs are classified and labeled as positive or negative pairs using pseudo-labels based on the docking energy scores, and the deep learning model is iteratively retrained based on the extended TCR-peptide training dataset and the pseudo-labels until convergence.

    BINDING PEPTIDE GENERATION FOR MHC CLASS I PROTEINS WITH DEEP REINFORCEMENT LEARNING

    公开(公告)号:US20230085160A1

    公开(公告)日:2023-03-16

    申请号:US17899004

    申请日:2022-08-30

    Abstract: A method for generating binding peptides presented by any given Major Histocompatibility Complex (MHC) protein is presented. The method includes, given a peptide and an MHC protein pair, enabling a Reinforcement Learning (RL) agent to interact with and exploit a peptide mutation environment by repeatedly mutating the peptide and observing an observation score of the peptide, learning to form a mutation policy, via a mutation policy network, to iteratively mutate amino acids of the peptide to obtain desired presentation scores, and generating, based on the desired presentation scores, qualified peptides and binding motifs of MHC Class I proteins.

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