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公开(公告)号：US20180162846A1
公开(公告)日：2018-06-14
申请号：US15674230
申请日：2017-08-10
Applicant: CHEMOCENTRYX, INC.
Inventor： Trevor T. CHARVAT , Junfa FAN , Christopher W. LANGE , Manmohan Reddy LELETI , Yandong LI , Venkat Reddy MALI , Jeffrey P. McMAHON , Jay POWERS , Sreenivas PUNNA , Ju YANG
IPC: C07D413/06 , A61K31/5377 , C07D401/04 , A61K31/495 , A61K31/4545 , A61K31/454 , A61K31/451 , C07D211/34 , C07D207/16 , C07D241/04 , C07D211/70 , C07D211/26 , C07D211/62 , C07D295/135 , C07D211/56 , C07D417/04 , C07D405/06 , C07D403/06 , C07D401/06 , A61K31/496
CPC classification number: C07D413/06 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/70 , C07D241/04 , C07D295/135 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04
Abstract: Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US20180092902A1
公开(公告)日：2018-04-05
申请号：US15709012
申请日：2017-09-19
Applicant: CHEMOCENTRYX, INC.
Inventor： Daniel DAIRAGHI , Dean R. DRAGOLI , Jaroslaw KALISIAK , Christopher W. LANGE , Manmohan Reddy LELETI , Yandong LI , Rebecca M. LUI , Venkat Reddy MALI , Viengkham MALATHONG , Jay P. POWERS , Hiroko TANAKA , Joanne TAN , Matthew J. WALTERS , Ju YANG , Penglie ZHANG
IPC: A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
CPC classification number: A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US20180086766A1
公开(公告)日：2018-03-29
申请号：US15692739
申请日：2017-08-31
Applicant: CHEMOCENTRYX, INC.
Inventor： Junfa FAN , Antoni KRASINSKI , Christopher W. LANGE , Rebecca M. LUI , Jeffrey P. McMAHON , Jay P. POWERS , Yibin ZENG , Penglie ZHANG
IPC: C07D487/04 , G01N33/574 , A61K51/04
CPC classification number: C07D487/04 , A61K51/0459 , G01N33/57492 , G01N2333/7158
Abstract: Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
