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    Variant activin receptor
    21.
    发明授权
    Variant activin receptor 有权

    公开(公告)号：US10407487B2

    公开(公告)日：2019-09-10

    申请号：US15714726

    申请日：2017-09-25

    Applicant: Amgen Inc.

    Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Hui-Quan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K14/71 ,  A61K38/00

    Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

    Variant activin IIB receptor
    24.
    发明授权
    Variant activin IIB receptor 有权
    变异激活素IIB受体

    公开(公告)号：US09447165B2

    公开(公告)日：2016-09-20

    申请号：US14204460

    申请日：2014-03-11

    Applicant: Amgen Inc.

    Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Hui-Quan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

    Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

    Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。

    Variant activin IIB receptor
    25.
    发明授权
    Variant activin IIB receptor 有权

    公开(公告)号：US09382309B2

    公开(公告)日：2016-07-05

    申请号：US14204460

    申请日：2014-03-11

    Applicant: Amgen Inc.

    Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Hui-Quan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K14/71

    Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

    Anti-Activin A Antibodies and Uses Thereof
    27.
    发明申请
    Anti-Activin A Antibodies and Uses Thereof 审中-公开
    抗激素A抗体及其用途

    公开(公告)号：US20150086556A1

    公开(公告)日：2015-03-26

    申请号：US14260856

    申请日：2014-04-24

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K16/22

    CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    Abstract translation: 本公开提供与抗激活素A结合蛋白（包括抗体）相关或衍生的组合物和方法。 在具体实施方案中，本公开提供了完整的人，人源化和嵌合的抗激活蛋白A抗体，其结合人激活素A，激活素A结合片段和此类抗体的衍生物，以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断具有激素A相关疾病或包括与性腺癌，其他癌症，类风湿性关节炎和其它疾病相关的恶病质的病症的受试者。

    Isolated Nucleic Acid Molecules Encoding Variant Activin Receptor Polypeptides
    29.
    发明申请
    Isolated Nucleic Acid Molecules Encoding Variant Activin Receptor Polypeptides 有权
    分离的核酸分子编码变体激活素受体多肽

    公开(公告)号：US20140194355A1

    公开(公告)日：2014-07-10

    申请号：US14204460

    申请日：2014-03-11

    Applicant: Amgen Inc.

    Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Hui-Quan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

    Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

    Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。

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