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    Sustained delivery of polyionic bioactive agents
    23.
    发明授权
    Sustained delivery of polyionic bioactive agents 失效
    持续输送聚离子生物活性剂

    公开(公告)号：US06395029B1

    公开(公告)日：2002-05-28

    申请号：US09234011

    申请日：1999-01-19

    Applicant: Robert J. Levy

    Inventor： Robert J. Levy

    IPC: A61F200

    CPC classification number: B82Y5/00 ,  A61F2/82 ,  A61F2250/0098 ,  A61K47/6455 ,  A61K47/6937 ,  A61K48/00 ,  A61L17/145 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/606

    Abstract: The invention relates to compositions and methods for delivering a polyionic bioactive composition such as a nucleic acid to a tissue of an animal. The compositions of the invention include compositions which comprise a matrix comprising the polyionic bioactive agent and wherein at least most of the polyionic bioactive agent at the exterior portion of the matrix is present in a condensed form. The invention also includes methods of making such compositions, including particles, devices, bulk materials, and other objects which comprise, consist of, or are coated with such compositions. Methods of delivering a polyionic bioactive agent to an animal tissue are also described. The invention further includes a method of storing a nucleic acid.

    Abstract translation: 本发明涉及用于将聚离子生物活性组合物例如核酸递送至动物组织的组合物和方法。 本发明的组合物包括包含基质的组合物，所述基质包含聚离子生物活性剂，并且其中基质外部部分的至少大部分聚离子生物活性剂以浓缩形式存在。 本发明还包括制造这样的组合物的方法，包括颗粒，装置，散装材料以及其它包含这些组合物的组合物，或由这些组合物涂覆的物体。 还描述了将聚离子生物活性剂递送到动物组织的方法。 本发明还包括存储核酸的方法。

    System for controlled release of antiarrhythmic agents
    24.
    发明授权
    System for controlled release of antiarrhythmic agents 失效
    用于控制释放抗心律失常药物的系统

    公开(公告)号：US5387419A

    公开(公告)日：1995-02-07

    申请号：US37810

    申请日：1993-03-26

    Applicant: Robert J. Levy ,  Amnon Sintov

    Inventor： Robert J. Levy ,  Amnon Sintov

    IPC: A61K9/00 ,  A61K9/70

    CPC classification number: A61K9/0024 ,  A61K9/7007 ,  Y10S514/821

    Abstract: A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric matrix with an incorporated therapeutic agent for direct placement at the epicardium. Advantageously, the dosage form can be fabricated in such a manner as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, lidocaine, an antiarrhythmic depressant, is incorporated in polyurethane by a unique method which permits drug-loading of the polymeric matrix from about 5% up to 40% by weight, with about 25% to 30% in a preferred embodiment. A novel FeCl.sub.3 catalyst causes the polyurethane to polymerize despite the presence of drug in the polymeric matrix mixture.

    Abstract translation: 用于受控释放，特定地点递送治疗剂，特别是心肌药物如抗心律失常剂的系统包括具有用于直接置于心外膜的并入治疗剂的生物相容性聚合物基质。 有利地，剂型可以按照所需待处理的物理条件的性质来定制释放特性的方式制造。 在具体的说明性实施方案中，通过独特的方法将利多卡因，抗心律失常抑制剂掺入聚氨酯中，其允许聚合物基质的药物加载量为约5％至40％重量，优选的为约25％至30％ 实施例。 尽管在聚合物基质混合物中存在药物，但新型FeCl 3催化剂使聚氨酯聚合。

    MAGNETIC TARGETING DEVICE, SYSTEM AND METHOD
    26.
    发明申请
    MAGNETIC TARGETING DEVICE, SYSTEM AND METHOD 有权
    磁性定位装置，系统和方法

    公开(公告)号：US20130267762A1

    公开(公告)日：2013-10-10

    申请号：US13883054

    申请日：2011-10-27

    Applicant: Robert J. Levy ,  Michael Chorny ,  Ilia Fishbein

    Inventor： Robert J. Levy ,  Michael Chorny ,  Ilia Fishbein

    IPC: A61N2/00 ,  A61M25/10

    CPC classification number: A61N2/00 ,  A61K9/0009 ,  A61K9/5094 ,  A61K9/5115 ,  A61L29/14 ,  A61L29/18 ,  A61M25/10

    Abstract: A treatment system includes a magnetic targeting catheter and a plurality of MNP. The MNP may include one or more magnetic field-responsive agents and one or more therapeutic agents. The catheter may include an inner shaft having at least one lumen and a fluid delivery balloon adapted to administer a fluid from the inner shaft into a space surrounding the catheter. An expandable mesh formed of a magnetizable material may surround the fluid delivery balloon. The catheter may further include one or more occlusion balloons for controlling blood flow through a vessel in which the catheter is placed. A method of treating a medical condition may include advancing a magnetic targeting catheter to a site, deploying an expandable mesh connected to the catheter, applying a magnetic field to the mesh and depositing a plurality of MNP or cells loaded with MNP near the mesh.

    Abstract translation: 治疗系统包括磁性靶向导管和多个MNP。 MNP可以包括一种或多种磁场响应剂和一种或多种治疗剂。 导管可以包括具有至少一个内腔的内轴和适于将流体从内轴施加到围绕导管的空间的流体输送球囊。 由可磁化材料形成的可膨胀网可围绕流体输送球囊。 导管还可以包括一个或多个阻塞气囊，用于控制通过其中放置导管的血管的血流。 治疗医疗状况的方法可以包括将磁性靶向导管推进到位置，展开连接到导管的可扩张网，向网状物施加磁场并且在网格附近沉积多个MNP或装载有MNP的细胞。

    Photochemical activation of surfaces for attaching biomaterial
    29.
    发明授权
    Photochemical activation of surfaces for attaching biomaterial 有权
    用于附着生物材料的表面的光化学活化

    公开(公告)号：US08263127B2

    公开(公告)日：2012-09-11

    申请号：US12633593

    申请日：2009-12-08

    Applicant: Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    Inventor： Ivan Alferiev ,  Ilia Fishbein ,  Michael Chorny ,  Robert J. Levy ,  Benjamin Yellen ,  Darryl Williams

    IPC: A61K9/14 ,  A61K47/48

    CPC classification number: C08G63/91 ,  A61K31/765 ,  A61K31/785 ,  A61L27/50 ,  A61L2400/18 ,  C07K17/02 ,  C08F8/10 ,  C08F8/32 ,  C08F8/34 ,  C08F226/02 ,  C08F271/02 ,  C08F290/00 ,  C08F291/00 ,  C08J7/18 ,  C08L75/04 ,  C08F120/06 ,  C08F126/02

    Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

    Abstract translation: 一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。 一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上 。 组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。 还提供了将生物材料递送到细胞的方法。

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