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公开(公告)号：US10933130B2
公开(公告)日：2021-03-02
申请号：US16117320
申请日：2018-08-30
Inventor： David Weiner , Daniel Villarreal , Matthew Morrow , Jian Yan
IPC: A61K39/39 , A61K39/00 , A61K38/20 , C12N15/63 , A61K38/16 , C07K14/54 , A61K39/015 , A61K39/04 , A61K39/12 , C12N15/82 , A61K39/21 , C12N7/00 , A61K38/00 , C07K14/025 , C07K14/35 , C07K14/16 , C07K14/005 , C07K14/445 , C12N15/09
Abstract: Disclosed herein is a vaccine comprising an antigen and IL-33. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating cancer in a subject in need thereof. The methods may comprise administering the vaccine to the subject.
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22.发明申请
公开(公告)号：US20190307870A1
公开(公告)日：2019-10-10
申请号：US16302718
申请日：2017-05-19
Applicant: Ahmed S.I. Aly , The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
Inventor： David Weiner , Emma Reuschel , Bernadette Ferraro , Ahmed S.I. Aly
IPC: A61K39/015 , A61P33/06 , C07K14/445
Abstract: Provided herein are sequences of Plasmodium spp. liver stage exported proteins as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against malaria using the expression constructs provided herein.
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公开(公告)号：US10398769B2
公开(公告)日：2019-09-03
申请号：US14910136
申请日：2014-08-04
Applicant: The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , David B. Weiner , Jian Yan
Inventor： David B. Weiner , Jian Yan
IPC: A61K39/145 , A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA Influenza A of serotype H7N9 alone and in combination with HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
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公开(公告)号：US20190192650A1
公开(公告)日：2019-06-27
申请号：US16298006
申请日：2019-03-11
Inventor： David Weiner , Jian Yan
IPC: A61K39/12 , A61N1/32 , C07K14/005
CPC classification number: A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/70 , A61N1/327 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/42 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2760/16022 , C12N2760/16034 , C12N2760/16041 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
Abstract: Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV39 E6E7 and HPV45 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
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公开(公告)号：US20190153076A1
公开(公告)日：2019-05-23
申请号：US16098908
申请日：2017-05-05
Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , INOVIO PHARMACEUTICALS, INC.
Inventor： David Weiner , Ami Patel , Jian Yan
IPC: C07K16/12 , A61K39/40 , A61K31/407 , C07K16/46 , A61P31/04
Abstract: Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method of generation.
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26.发明申请
公开(公告)号：US20190046621A1
公开(公告)日：2019-02-14
申请号：US15884594
申请日：2018-01-31
Inventor： David Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y. Sardesai , Mathura P. Ramanathan
Abstract: Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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公开(公告)号：US20190009081A1
公开(公告)日：2019-01-10
申请号：US16066959
申请日：2016-12-28
Applicant: Inovio Pharmaceuticals, Inc.
Inventor： Beat Stadelmann
Abstract: A handset for an electroporation device having an improved signal generator. The signal generator includes a primary winding and a plurality of secondary windings where the plurality of secondary windings are coupled together in a series configuration. A storage capacitor and the fly-back diode are coupled to each of the plurality of secondary windings. The signal generator includes a signal amplifier, and a power switch. The power switch is configured to supply a voltage from a power source across the primary winding.
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公开(公告)号：US20190000489A1
公开(公告)日：2019-01-03
申请号：US16066919
申请日：2016-12-28
Applicant: Inovio Pharmaceuticals, Inc.
Inventor： Jay McCoy , Kate Broderick , Stephen Kemmerrer
Abstract: An jet injection and electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device including a housing having an axis extend therethrough, a nozzle at least partially positioned within the housing, and a cavity sized to receive at least a portion of the agent cartridge therein. The device also includes an array having a plurality of electrodes extending therefrom, a propulsion cartridge configured to operatively engage the cartridge when the agent cartridge is positioned within the cavity; and a power supply in electrical communication with the array.
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公开(公告)号：US09913885B2
公开(公告)日：2018-03-13
申请号：US15207271
申请日：2016-07-11
Inventor： David Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y. Sardesai , Mathura P. Ramanathan
CPC classification number: A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/485 , C12N9/6424 , C12Y116/01 , C12Y304/17021 , C12Y304/21077
Abstract: Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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30.发明申请PD1 AND PDL1 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR IMMUNOTHERAPY 审中-公开PD1和PDL1抗体和疫苗组合及其用于免疫疗法
公开(公告)号：US20170007693A1
公开(公告)日：2017-01-12
申请号：US15109900
申请日：2015-01-06
Inventor： David WEINER , Karupplah MUTHUMANI , Niranjan SARDESAI
CPC classification number: A61K39/12 , A61K9/0009 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K2039/505 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55516 , A61M2037/0007 , A61N1/327 , C07K16/2827 , C12N7/00 , C12N2710/20034 , Y02A50/412
Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
Abstract translation: 本文公开了包含抗原和PD1抗体和/或PDL1抗体的疫苗。 本文还公开了增强受试者的免疫应答的方法。 该方法可以包括向有需要的受试者施用疫苗。
