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24 条记录 (耗时 0.014 秒)

    CONJUGATE OF CATECHOL-MODIFIED POLYETHYLENE GLYCOL WITH PROTEIN OR PEPTIDE AND PREPARATION METHOD THEROF
    21.
    发明申请
    CONJUGATE OF CATECHOL-MODIFIED POLYETHYLENE GLYCOL WITH PROTEIN OR PEPTIDE AND PREPARATION METHOD THEROF 有权
    具有蛋白质或肽的CATECHOL改性聚乙烯甘油的结合物及其制备方法

    公开(公告)号：US20120208258A1

    公开(公告)日：2012-08-16

    申请号：US13133166

    申请日：2010-10-29

    申请人： Haeshin Lee ,  Hyukjin Lee ,  In Taek Song ,  Moon Sue Lee

    发明人： Haeshin Lee ,  Hyukjin Lee ,  In Taek Song ,  Moon Sue Lee

    IPC分类号： C07K17/08 ,  C12N9/96

    CPC分类号： C07K19/00 ,  A61K47/60 ,  C07K1/13

    摘要： The present invention relates to a conjugate of a protein or peptide with a polyethylene glycol derivative having catechol, wherein the protein or peptide is mono-PEGylated at the N-terminal with the polyethylene glycol derivative, and to a preparation method thereof. According to the invention, the catechol-PEG derivative can be site-specifically conjugated with the N-terminal amine group of a protein or peptide, so that a homogeneous polyethylene glycol-protein or -peptide conjugate can be obtained in high yield. Unlike a prior art conjugate, the conjugate obtained according to the invention allows the decrease in the activity of the protein to be minimized without chemically modifying the protein, and thus the conjugate has an excellent pharmacological effect. Also, because the conjugate is homogeneous, the process for preparing the conjugate can be simplified. Moreover, the conjugate has uniform biological efficacy in vivo and shows strong resistance to hydrolysis and thus a long in vivo duration time. Accordingly, the conjugate has the effect of increasing the in vivo efficacy and stability of the protein drug.

    摘要翻译： 本发明涉及蛋白质或肽与具有儿茶酚的聚乙二醇衍生物的缀合物及其制备方法，其中所述蛋白质或肽在N-末端与聚乙二醇衍生物单PEG化。 根据本发明，儿茶酚-PEG衍生物可以与蛋白质或肽的N-末端胺基位点特异性缀合，从而可以高产率获得均匀的聚乙二醇 - 蛋白质或肽结合物。 与现有技术的缀合物不同，根据本发明获得的缀合物允许在不化学修饰蛋白质的情况下使蛋白质的活性降低至最小，因此缀合物具有优异的药理作用。 另外，由于缀合物是均相的，因此可以简化制备缀合物的方法。 此外，缀合物在体内具有均一的生物学功效，并且显示出很强的抗水解性，因此具有长的体内持续时间。 因此，缀合物具有增加蛋白质药物的体内功效和稳定性的作用。

    CARBON NANOTUBE BULK MATERIAL AND METHOD OF FABRICATING THE SAME
    23.
    发明申请
    CARBON NANOTUBE BULK MATERIAL AND METHOD OF FABRICATING THE SAME 失效
    碳纳米管块材料及其制造方法

    公开(公告)号：US20100314586A1

    公开(公告)日：2010-12-16

    申请号：US12702479

    申请日：2010-02-09

    申请人： Soonhyung Hong ,  Seongwoo Ryu ,  Jaewon Hwang ,  Taegwan Park ,  Haeshin Lee ,  Yuhan Lee

    发明人： Soonhyung Hong ,  Seongwoo Ryu ,  Jaewon Hwang ,  Taegwan Park ,  Haeshin Lee ,  Yuhan Lee

    IPC分类号： H01B1/24 ,  B05D5/12

    CPC分类号： C08K9/08

    摘要： A carbon nanotube bulk material is provided. The carbon nanotube bulk material includes carbon nanotubes constituting a matrix and a polymer binder interposed between the carbon nanotubes. The polymer binder includes a polymer backbone and at least one organic moiety grafted to a terminal or a side of the polymer backbone. The organic moiety has a C3-C24 aromatic functional group having at least one hydroxy group.

    摘要翻译： 提供了碳纳米管散装材料。 碳纳米管本体材料包括构成基体的碳纳米管和介于碳纳米管之间的聚合物粘合剂。 聚合物粘合剂包括聚合物主链和至少一个接枝到聚合物主链的末端或侧面上的有机部分。 有机部分具有至少一个羟基的C 3 -C 24芳族官能团。