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37 条记录 (耗时 0.054 秒)

    Imidazol-2-carboxamide derivatives as raf kinase inhibitors
    22.
    发明授权
    Imidazol-2-carboxamide derivatives as raf kinase inhibitors 失效
    咪唑-2-甲酰胺衍生物作为raf激酶抑制剂

    公开(公告)号：US06987119B2

    公开(公告)日：2006-01-17

    申请号：US10220675

    申请日：2001-03-02

    申请人： Alessandra Gaiba ,  Andrew Kenneth Takle ,  David Matthew Wilson

    发明人： Alessandra Gaiba ,  Andrew Kenneth Takle ,  David Matthew Wilson

    IPC分类号： A61K31/44 ,  C07D401/04

    CPC分类号： C07D401/04

    摘要： Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heterocyclyl, heterocyclyl-C1-6alkyl, heteroaryl, or heteroarylC1-6alkyl any of which except hydrogen may be optionally substituted; R2 and R3 independently represent hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heteroaryl, heteroarylC1-6alkyl, heterocyclyl, or heterocyclylC1-6alkyl any one of which except hydrogen may be optionally substituted, or R2 and R3 together with the nitrogen atom to which they are attached form a 4- to 10-membered optionally substituted monocyclic or bicyclic ring; Ar is an aryl or heteroaryl ring either of which may be optionally substituted; one of X1 and X2 is N and the other is NR4, wherein R4 is hydrogen, C1-6alkyl, or arylC1-6alkyl; or pharmaceutically acceptable salts thereof; their use as inhibitors of Raf kinases and pharmaceutical compositions containing them.

    摘要翻译： 式（I）的化合物：其中X是O，CH 2，S或NH，或X-R 1部分是氢; V是CH或N; R 1是氢，C 1-6烷基，C 3-7环烷基，芳基，芳基C 1-6 烷基，杂环基，杂环基-C 1-6烷基，杂芳基或杂芳基C 1-6烷基，除氢以外的任何一个可以任选被取代; R 2和R 3独立地表示氢，C 1-6烷基，C 3-7环烷基，芳基 ，芳基C 1-6烷基，杂芳基，杂芳基C 1-6烷基，杂环基或杂环基C 1-6烷基，除氢以外的任何一个 可以任选地被取代，或者R 2和R 3与它们所连接的氮原子一起形成4-至10-元任选取代的单环或双环; Ar是任选被取代的芳基或杂芳基环; X 1和X 2之一是N，另一个是NR 4，其中R 4是氢， C 1-6烷基或芳基C 1-6烷基; 或其药学上可接受的盐; 它们用作Raf激酶的抑制剂和含有它们的药物组合物。

    Self-adjusting wave break
    24.
    发明申请
    Self-adjusting wave break 审中-公开
    自调波浪破裂

    公开(公告)号：US20100178109A1

    公开(公告)日：2010-07-15

    申请号：US12457188

    申请日：2009-06-03

    申请人： Dave David Matthew Wilson

    发明人： Dave David Matthew Wilson

    IPC分类号： E02B3/04

    CPC分类号： E02B3/062

    摘要： The wave break has an elongated shape and three wave-breaking surfaces mounted thereon and forming an elongated triangular configuration. The wave break has a lazy side on its forward edge, such that the force of the wave tilts it about the forward edge to increase a projection of its wave-breaking surfaces against the incoming wave. Because of the lazy forward side of the wave break, the leading stringer dive into each wave without deviating substantially from a horizontal plane. The trailing side of the wave break is subject to the lifting forces of each wave and therefore, the trailing side tilts upward and downward in use. The trailing side tilts upward and downward about the leading stringer to rotate the wave-breaking barriers into a more or less perpendicular alignment relative to the wave movement, for breaking the wave more effectively.

    摘要翻译： 波浪断裂具有细长形状和安装在其上的三个波浪形表面并形成细长的三角形构造。 波浪断裂在其前缘具有懒惰的一侧，使得波的力将其围绕前缘倾斜以增加其波浪破坏表面相对于入波的投影。 由于波浪the懒的前方，主要的纵梁潜入每一波而不会从水平面上大幅偏离。 波浪断裂的尾部受到每个波浪的提升力的影响，因此在使用中，尾部侧向上和向下倾斜。 后缘侧围绕着前纵梁向上和向下倾斜，以将波浪破坏障碍物相对于波浪运动旋转成或多或少的垂直对准，以更有效地打破波浪。