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公开(公告)号：US20240391900A1
公开(公告)日：2024-11-28
申请号：US18692053
申请日：2022-09-14
Applicant: SIRONAX (BEIJING) CO., LTD.
Inventor： Yaning Su , Hanying Ruan , Zhiyuan Zhang , Yanping Xu , Yimin Jianng
IPC: C07D401/14 , A61K31/416 , A61K31/4178 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , C07D401/04 , C07D401/10 , C07D403/08 , C07D403/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048
Abstract: Provided are novel compounds of general formula (I) that inhibit RIP1 kinase or a pharmaceutically acceptable salt thereof, a composition comprising such compounds, and use of such compounds in inhibiting programmed necrosis, inhibiting RIP1 kinase, or treating or preventing a disease that is at least partially mediated by RIP1 kinase.
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公开(公告)号：US20240383910A1
公开(公告)日：2024-11-21
申请号：US18664964
申请日：2024-05-15
Applicant: Baylor College of Medicine
Inventor： Wen-Hao Guo , Xin Yu , Ran Cheng , Jin Wang
IPC: C07D491/048 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/519 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/12
Abstract: Novel small molecule proteolysis-targeting chimeras (PROTACs) are provided, along with methods for their use as Bruton's tyrosine kinase (BTK) degraders. The small molecule PROTACs described herein are useful in treating and/or preventing BTK-related diseases, such as cancer, neurodegenerative disorders, inflammatory diseases, and metabolic disorders. Also provided are methods for inducing BTK degradation in a cell using the compounds and compositions described herein.
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公开(公告)号：US20240368176A1
公开(公告)日：2024-11-07
申请号：US18647107
申请日：2024-04-26
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Adam SZYMANIAK , Kevin McGRATH , Jianming YU , Tyler J. MANN , Long NGUYEN , Kaicheng ZHU , In Jong KIM , Yat Sun OR
IPC: C07D491/052 , C07D471/04 , C07D491/044 , C07D491/048
Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20240368175A1
公开(公告)日：2024-11-07
申请号：US18775916
申请日：2024-07-17
Applicant: Chuan Shih
Inventor： Tsu-An HSU , Hsing-Pang HSIEH , Sue-Ming CHANG
IPC: C07D491/048
Abstract: Disclosed herein is a specific crystalline forms of (S, E)-4-(dimethylamino)-N-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide (ABT-101) free base, the pharmaceutical composition and capsule comprising the same, and the medical application thereof. Said crystalline forms of ABT-101 free base can exhibit unexpected stability and improved pharmacokinetic properties compared to other forms or salt thereof, thereby allowing said compound more suitable for drug development and satisfying the requirements for bioavailability and drug efficacy.
![CRYSTALLINE FORMS OF (S, E)-4-(DIMETHYLAMINO)-N-(3-(4-(2-HYDROXY-1-PHENYLETHYLAMINO)-6-PHENYLFURO[2,3-D]PYRIMIDIN-5-YL)PHENYL)BUT-2-ENAMIDE FREE BASE](/docs/US/2024-11-07/US20240368175A1/abs.jpg.600x600.jpg)
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公开(公告)号：US20240368160A1
公开(公告)日：2024-11-07
申请号：US18763302
申请日：2024-07-03
Applicant: Ventus Therapeutics U.S., Inc.
Inventor： Stéphane DORICH , Jason BURCH , Miguel ST-ONGE , Amandine CHEFSON , Alexandre CÔTÉ
IPC: C07D471/04 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/5377 , C07D405/12 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):
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公开(公告)号：US20240360114A1
公开(公告)日：2024-10-31
申请号：US18293357
申请日：2022-08-09
Applicant: SIRONAX LTD.
Inventor： Jianguang HAN , Weijie HOU , Zhiyuan ZHANG , Yanping XU , Yimin JIANG , Xingyu XU
IPC: C07D413/04 , A61K31/4427 , A61K31/47 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/553 , C07C211/48 , C07D213/74 , C07D215/10 , C07D215/16 , C07D241/04 , C07D265/30 , C07D401/04 , C07D413/14 , C07D487/08 , C07D491/048 , C07D491/107
CPC classification number: C07D413/04 , A61K31/4427 , A61K31/47 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/553 , C07C211/48 , C07D213/74 , C07D215/10 , C07D215/16 , C07D241/04 , C07D265/30 , C07D401/04 , C07D413/14 , C07D487/08 , C07D491/048 , C07D491/107
Abstract: This disclosure provides compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those involving ferroptosis.
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公开(公告)号：US12133459B2
公开(公告)日：2024-10-29
申请号：US17282678
申请日：2020-01-13
Applicant: LG CHEM, LTD.
Inventor： Sang Duk Suh , Dong Hoon Lee , Boon Jae Jang , Min Woo Jung , Jungha Lee , Su Jin Han , Seulchan Park , Sunghyun Hwang
IPC: H10K85/60 , C07D491/048 , C07D495/04 , H10K50/11
CPC classification number: H10K85/654 , C07D491/048 , C07D495/04 , H10K85/657 , H10K85/6572 , H10K85/6574 , H10K50/11
Abstract: A heterocyclic compound represented by Chemical Formula 1 and an organic light emitting device comprising the same, and the heterocyclic compound used as a material of an organic material layer of the organic light emitting device and providing improved properties of efficiency, driving voltage and lifetime characteristics of the organic light emitting device.
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公开(公告)号：US20240343709A1
公开(公告)日：2024-10-17
申请号：US18746835
申请日：2024-06-18
Applicant: KayoThera Inc. , The Trustees of Princeton University
Inventor： Mark ESPOSITO , John PROUDFOOT , Yibin KANG , John PIWINSKI
IPC: C07D401/12 , A61P35/00 , C07D215/50 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D498/04 , C07D513/04
CPC classification number: C07D401/12 , A61P35/00 , C07D215/50 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D498/04 , C07D513/04
Abstract: Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
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公开(公告)号：US20240336608A1
公开(公告)日：2024-10-10
申请号：US18617907
申请日：2024-03-27
Applicant: Merck Sharp & Dohme LLC
Inventor： David A. Candito , Anthony Donofrio , Ronald Dale Ferguson, II , George Madalin Giambasu , Anmol Gulati , Andrew M. Haidle , Brett A. Hopkins , William P. Kaplan , Ping Liu , Michaelyn C. Lux , Xiao Mei Zheng , Ryan D. Otte , Alexander Pasternak , Elsie C. Yu
IPC: C07D417/14 , A61K31/422 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/542 , A61K39/395 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04
CPC classification number: C07D417/14 , A61K31/422 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/542 , A61K39/3955 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04
Abstract: Described herein are compounds of Formula I
or a pharmaceutically acceptable salt thereof, wherein R1, R2, A, and B are as defined herein. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.
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公开(公告)号：US12110288B2
公开(公告)日：2024-10-08
申请号：US17112906
申请日：2020-12-04
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Do Yeon Kwon , Thomas L Little , Markus Metz , Peter Kurt Nollert von Specht , Jennifer Tsoung , Jeremiah H. Nguyen , Melinda Davis , Robert Huerta Lemus , Santosh Kumar Keshipeddy , Sara Rebecca Goldstein
IPC: C07D471/04 , A61K31/495 , A61K31/497 , C07D239/545 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D491/048 , C07D495/04 , C07D519/00
CPC classification number: C07D471/04 , C07D239/545 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
