公开(公告)号：US20220074947A1

公开(公告)日：2022-03-10

申请号：US17325036

申请日：2021-05-19

Applicant: UCB Biopharma SRL ,  SANOFI

Inventor： James Philip O'CONNELL ,  John Robert PORTER ,  Alastair LAWSON ,  Tracy Lynn ARAKAKI ,  Daniel John LIGHTWOOD ,  Rebecca Jayne MUNRO

IPC: G01N33/68 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705 ,  C07K16/24 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US20210107971A1

公开(公告)日：2021-04-15

申请号：US16771993

申请日：2018-12-13

Applicant: UCB Biopharma SRL

Inventor： Ralph ADAMS ,  Patrick DOWNEY ,  Terence Seward BAKER ,  Kerry Louise TYSON ,  Lorenzo DE LICHTERVELDE ,  Daniel John LIGHTWOOD ,  David James MCMILLAN

IPC: C07K16/18

Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.