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公开(公告)号：US20180101487A1
公开(公告)日：2018-04-12
申请号：US15709274
申请日：2017-09-19
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： Bill James PECK
IPC: G06F13/16 , C07H21/04 , G06F12/14 , G06F12/0875 , G06F13/42
Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Additionally, devices described herein for de novo synthesis of nucleic acids encoding information related to the original source information may be rigid or flexible material. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Also provided herein are methods and systems for efficient transfer of preselected polynucleotides from a storage structure for reading stored information.
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公开(公告)号：US20160310927A1
公开(公告)日：2016-10-27
申请号：US15135434
申请日：2016-04-21
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE , Eugene P. MARSH
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00317 , B01J2219/00497 , B01J2219/00511 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00635 , B01J2219/00637 , B01J2219/00662 , B01J2219/00722 , B01L3/50857 , C12N15/1093 , C12Q2563/159 , C12Q2565/513 , C12Q2565/629
Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.
Abstract translation: 本文提供了用于从头合成大量和高精度的寡核酸文库的装置和方法。 器件包括具有主通道和微通道的结构，其中微通道具有高表面积与体积比。 本文公开的装置提供具有低错误率的寡核酸的从头合成。
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公开(公告)号：US20160251651A1
公开(公告)日：2016-09-01
申请号：US15156134
申请日：2016-05-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE
IPC: C12N15/10
CPC classification number: C12N15/1093 , C12Q1/6806 , C12Q2521/501 , C12Q2525/179 , C12Q2525/191 , C12Q2525/204 , C12Q2525/307 , C12Q2527/143 , C12Q2531/113 , C12Q2535/122 , C12Q2563/149 , C12Q2563/159 , C12Q2565/626 , C12Q2531/125
Abstract: Methods and devices for cell-free sorting and cloning of nucleic acid libraries are provided herein.
Abstract translation: 本文提供了用于无细胞分选和克隆核酸文库的方法和装置。
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公开(公告)号：US20230338913A1
公开(公告)日：2023-10-26
申请号：US18319356
申请日：2023-05-17
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE , Eugene P. MARSH
CPC classification number: B01J19/0046 , C12N15/1093 , B01J2219/00596 , B01J2219/00722 , B01J2219/00497 , B01J2219/00585 , B01J2219/00317 , B01J2219/00511 , B01J2219/00522 , B01J2219/00635 , B01J2219/00637 , B01J2219/00662 , B01L3/50857
Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.
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公开(公告)号：US20220325276A2
公开(公告)日：2022-10-13
申请号：US15156134
申请日：2016-05-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE , Cheng-Hsien WU , Esteban TORO
IPC: C12N15/10
Abstract: Methods and devices for cell-free sorting and cloning of nucleic acid libraries are provided herein.
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公开(公告)号：US20200222875A1
公开(公告)日：2020-07-16
申请号：US16726073
申请日：2019-12-23
Applicant: Twist Bioscience Corporation
Inventor： Bill James PECK , Mary NOE , Stefan PITSCH , Patrick A. Weiss
Abstract: Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or byproducts from previous synthetic steps to allow for the generation of polynucleotides with low error rates. Processes described herein also provide for reduction in deletion rates during chemical nucleic acid synthesis. Further, methods and devices described herein allow for the rapid construction and assembly of large libraries of highly accurate polynucleotides.
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公开(公告)号：US20190240636A1
公开(公告)日：2019-08-08
申请号：US16384678
申请日：2019-04-15
Applicant: Twist Bioscience Corporation
Inventor： Bill James PECK , Pierre INDERMUHLE , Eugene P. MARSH , Andres FERNANDEZ , David STERN
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00441 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00619 , B01J2219/00637 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722
Abstract: Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis. Provided herein are processes which include use of lamps, lasers, and/or microcontact printing to add functional groups to surfaces for the efficient and uniform synthesis of oligonucleic acids.
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公开(公告)号：US20160090592A1
公开(公告)日：2016-03-31
申请号：US14885962
申请日：2015-10-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE
IPC: C12N15/10
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US20160089651A1
公开(公告)日：2016-03-31
申请号：US14885965
申请日：2015-10-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US20230211308A1
公开(公告)日：2023-07-06
申请号：US18067652
申请日：2022-12-16
Applicant: Twist Bioscience Corporation
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE
CPC classification number: B01J19/0046 , C12N15/1093 , C40B50/18 , C12N15/66 , C12N15/1096 , C12N15/74 , B01J2219/00722 , B01J2219/00596 , B01J2219/0059 , B01J2219/00587 , C40B50/00
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
