公开(公告)号：US20190389895A1

公开(公告)日：2019-12-26

申请号：US16555222

申请日：2019-08-29

Applicant: THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Ryan Hudson ,  Daniel D. Long ,  Donna A.A. Wilton ,  Mandy Loo ,  Patrick J. Brassil

IPC: C07H15/26 ,  C12P17/16

Abstract: The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.

公开(公告)号：US20230399312A1

公开(公告)日：2023-12-14

申请号：US18140423

申请日：2023-04-27

Applicant: THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Mandy Loo ,  Svitlana Kulyk ,  Christopher Bailey ,  Jennifer Kozak ,  Matthew B. Soellner ,  Adam D. Hughes

IPC: C07D401/14 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P35/00 ,  A61K9/00 ,  A61K45/06

CPC classification number: C07D401/14 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P35/00 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K45/06 ,  A61K31/506

Abstract: The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

公开(公告)号：US20230218597A1

公开(公告)日：2023-07-13

申请号：US18093250

申请日：2023-01-04

Applicant: THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Christina Owens ,  Svitlana Kulyk ,  Steven D.E. Sullivan ,  Paul Allegretti ,  Mandy Loo ,  Jennifer Kozak ,  Chen Zhao ,  Erik Fenster ,  Adam D. Hughes

IPC: A61K31/444 ,  A61P35/00 ,  C07D487/04 ,  A61K31/5377 ,  A61P11/00 ,  A61K9/00 ,  A61K31/4709 ,  C07D487/08 ,  C07D519/00 ,  A61P19/04 ,  C07D409/14 ,  C07D471/04 ,  A61K31/4995 ,  A61K45/06 ,  A61K31/4985 ,  C07D401/14 ,  A61K31/496 ,  C07D513/04 ,  C07D405/14 ,  C07D417/14 ,  A61K31/519

CPC classification number: A61K31/444 ,  A61P35/00 ,  C07D487/04 ,  A61K31/5377 ,  A61P11/00 ,  A61K9/0073 ,  A61K31/4709 ,  C07D487/08 ,  C07D519/00 ,  A61P19/04 ,  C07D409/14 ,  C07D471/04 ,  A61K31/4995 ,  A61K45/06 ,  A61K31/4985 ,  C07D401/14 ,  A61K31/496 ,  C07D513/04 ,  C07D405/14 ,  C07D417/14 ,  A61K31/519

Abstract: The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

公开(公告)号：US11590116B2

公开(公告)日：2023-02-28

申请号：US16949915

申请日：2020-11-20

Applicant: THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Christina Owens ,  Svitlana Kulyk ,  Steven D. E. Sullivan ,  Paul Allegretti ,  Mandy Loo ,  Jennifer Kozak ,  Erik Fenster ,  Adam D. Hughes

IPC: C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D513/04 ,  C07D519/00 ,  A61K31/444 ,  A61P19/04 ,  A61P11/00 ,  A61P35/00 ,  A61K9/00 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/4995 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06

Abstract: The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

公开(公告)号：US20170145044A1

公开(公告)日：2017-05-25

申请号：US15358462

申请日：2016-11-22

Applicant: THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Ryan Hudson ,  Daniel D. Long ,  Donna A.A. Wilton ,  Mandy Loo

IPC: C07H15/26 ,  C12P17/16

CPC classification number: C07H15/26 ,  C07D487/04 ,  C07H1/00 ,  C12P17/165

Abstract: The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.