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公开(公告)号：US20230242602A1
公开(公告)日：2023-08-03
申请号：US17791395
申请日：2021-01-22
发明人： Bryan Zeitler , Asa Hatami , Lei Zhang
CPC分类号： C07K14/4703 , C07K14/4711 , C12N15/86 , A61P25/28 , C12N2750/14143 , C07K2319/71
摘要： The present disclosure provides zinc finger fusion proteins that inhibit expression of tau in the nervous system, and methods of using the proteins to treat neurodegenerative diseases such as Alzheimer's disease, frontotemporal dementia, and other tauopathies.
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公开(公告)号：US20230002459A1
公开(公告)日：2023-01-05
申请号：US17766083
申请日：2020-10-02
发明人： Bryan Zeitler , Lei Zhang
摘要： The present disclosure provides zinc finger fusion proteins that inhibit expression of the prion gene in the nervous system, and methods of using the proteins to treat prion disease.
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公开(公告)号：US11279739B2
公开(公告)日：2022-03-22
申请号：US16386885
申请日：2019-04-17
摘要： The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
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公开(公告)号：US11421007B2
公开(公告)日：2022-08-23
申请号：US16386885
申请日：2019-04-17
摘要： The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
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公开(公告)号：US20190322711A1
公开(公告)日：2019-10-24
申请号：US16386885
申请日：2019-04-17
摘要： The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
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