公开(公告)号：US20160331326A1

公开(公告)日：2016-11-17

申请号：US15043688

申请日：2016-02-15

Applicant: National University of Singapore

Inventor： Zhuolin XIANG ,  Shih-Cheng YEN ,  Chengkuo LEE ,  Sanghoon LEE ,  Nitish V. THAKOR ,  Amitabha LAHIRI ,  Faith Ann BAZLEY ,  Ashwati VIPIN ,  Ignacio Delgado MARTINEZ ,  Angelo Homayoun ALL ,  Yen Xian PEH

IPC: A61B5/00 ,  A61N1/05 ,  A61B5/04

CPC classification number: A61B5/6877 ,  A61B5/04001 ,  A61B2562/164 ,  A61B2562/166 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/3756

Abstract: Embodiments in accordance with the present disclosure are directed to non-invasive or essentially non-invasive electrode structures, assemblies, and devices for sensing neural signals carried or produced by peripheral nerves, and/or applying stimulation signals to peripheral nerves. Electrode structures, assemblies, and devices in accordance with embodiments of the present disclosure include (a) flexible epineural strip electrode structures having one or more elongate electrode-carrying strips that can be adhered (e.g., glued) and/or sutured to a peripheral nerve; (b) flexible elongate ribbon electrode structures, which can be spirally wound about portions of a peripheral nerve's length such that microneedle and/or disc or stud type electrodes carried by the ribbon electrode structure are disposed in a helical arrangement about the peripheral nerve; and (c) an embedded nerve tissue—electrode interface having a tubular compartment containing adipose tissue that supports axonal tissue ingrowth and interfacing of ingrown axonal tissue with electrode microwires in the compartment.

Abstract translation: 根据本公开的实施例涉及用于感测由周围神经携带或产生的神经信号和/或向周围神经施加刺激信号的非侵入式或基本上非侵入性的电极结构，组件和装置。 根据本公开实施例的电极结构，组件和装置包括（a）具有一个或多个细长电极携带条带的柔性神经带状电极结构，其可以粘附（例如胶合）和/或缝合到周围神经 ; （b）柔性细长带状电极结构，其能够围绕周围神经长度的部分螺旋卷绕，使得由带状电极结构携带的微针和/或盘或螺柱型电极以围绕周围神经的螺旋形布置; 和（c）嵌入神经组织 - 电极界面，其具有包含脂肪组织的管状隔室，所述脂肪组织支持轴突组织向内生长并且将内向轴索组织与隔室中的电极微丝接合。