公开(公告)号：US20160272632A1

公开(公告)日：2016-09-22

申请号：US14778046

申请日：2014-03-19

Applicant: Matthew Lloyd CHILDERS ,  Peter FULLER ,  David GUERIN ,  Jason David KATZ ,  Qinglin PU ,  Mark E. SCOTT ,  Christopher E. THOMPSON ,  Michelle MARTINEZ ,  Danielle FALCONE ,  Luis TORRES ,  Yongqi DENG ,  Ravi KURUKULASURIYA ,  Hongbo ZENG ,  Yunfeng BAI ,  Norman KONG ,  Yumei LIU ,  MERCK SHARP & DOHME CORP.

Inventor： Matthew Lloyd Childers ,  Peter Fuller ,  David Guerin ,  Jason David Katz ,  Qinglin Pu ,  Mark E. Scott ,  Christopher F. Thompson ,  Michelle Martinez ,  Danielle Falcone ,  Luis Torres ,  Yongqi Deng ,  Ravi Kurukulasuriya ,  Hongbo Zeng ,  Yunfeng Bai ,  Norman Kong ,  Yumei Liu ,  Zhixiang Zheng

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract translation: 本发明提供了作为JAK抑制剂的式（I）化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。