公开(公告)号：US20180362661A1

公开(公告)日：2018-12-20

申请号：US16101861

申请日：2018-08-13

Applicant: Merck Sharp & Dohme Corp. ,  Adimab, LLC

Inventor： Zhu Chen ,  Kenneth Ellsworth ,  James A. Milligan ,  Elizabeth Oldham ,  Dietmar Seiffert ,  Vaishnavi Ganti ,  Mohammad Tabritzifard ,  Bianka Prinz

IPC: C07K16/36 ,  A61K39/395 ,  A61P7/02 ,  C07K16/30 ,  C07K14/745 ,  A61K39/00

Abstract: Antibodies that bind the apple 2 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa are described.