公开(公告)号：US20230116885A1

公开(公告)日：2023-04-13

申请号：US17966689

申请日：2022-10-14

申请人： Myriad Genetics, Inc.

发明人： Alexander Gutin ,  Julia Reid ,  Ralf Kronenwett ,  Marsel Scheer

IPC分类号： C12Q1/6886 ,  G16H70/60 ,  G16H50/20 ,  G16H20/10 ,  G16B25/10 ,  G16B20/00

摘要： Provided herein are methods for predicting chemotherapy benefit. The invention predicts chemotherapy benefit based on the expression analysis of biomarkers, e.g., RNA biomarker transcription analysis, taken from a tumor sample. The biomarker expression data can be combined with clinical variables, e.g., tumor size and nodal status, to generate a profile that predicts the benefit of including chemotherapy as a treatment decision.

公开(公告)号：US11505832B2

公开(公告)日：2022-11-22

申请号：US16809338

申请日：2020-03-04

申请人： MYRIAD GENETICS, INC.

发明人： Alexander Gutin ,  Julia Reid ,  Ralf Kronenwett ,  Marsel Scheer

IPC分类号： C12Q1/6886 ,  G16H70/60 ,  G16H50/20 ,  G16H20/10 ,  G16B25/10 ,  G16B20/00

摘要： Provided herein are methods for predicting chemotherapy benefit. The invention predicts chemotherapy benefit based on the expression analysis of biomarkers, e.g., RNA biomarker transcription analysis, taken from a tumor sample. The biomarker expression data can be combined with clinical variables, e.g., tumor size and nodal status, to generate a profile that predicts the benefit of including chemotherapy as a treatment decision.

公开(公告)号：US11174517B2

公开(公告)日：2021-11-16

申请号：US15349866

申请日：2016-11-11

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Julia Reid

IPC分类号： C12Q1/6886

摘要： Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.

公开(公告)号：US20150247208A1

公开(公告)日：2015-09-03

申请号：US14713636

申请日：2015-05-15

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.

摘要翻译： 提供了使用生物标志物在患者中分类癌症的生物标志物和方法（例如，预测癌症特异性死亡或癌症复发的风险）。

公开(公告)号：US20140212415A1

公开(公告)日：2014-07-31

申请号：US14172632

申请日：2014-02-04

申请人： Myriad Genetics, Inc.

发明人： Alexander Gutin ,  Srikanth Jammulapati ,  Susanne Wagner ,  Julia Reid ,  Darl Flake

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Biomarkers, particularly hypoxia-related genes, and methods using the biomarkers for molecular classification of disease are provided.

摘要翻译： 提供了生物标志物，特别是缺氧相关基因，以及使用生物标志物进行疾病分子分类的方法。

公开(公告)号：US20220112565A1

公开(公告)日：2022-04-14

申请号：US17484179

申请日：2021-09-24

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Julia Reid

IPC分类号： C12Q1/6886

摘要： Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.

公开(公告)号：US20210071269A1

公开(公告)日：2021-03-11

申请号：US17096755

申请日：2020-11-12

申请人： MYRIAD GENETICS, INC.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/6886

摘要： Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.

公开(公告)号：US20190185939A1

公开(公告)日：2019-06-20

申请号：US16221165

申请日：2018-12-14

申请人： Myriad Genetics, Inc.

发明人： Victor Abkevich ,  Kirsten Timms ,  Alexander Gutin ,  Julia Reid

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US20180265930A1

公开(公告)日：2018-09-20

申请号：US15919394

申请日：2018-03-13

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16B20/00 ,  G16B40/00

摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US20170152571A1

公开(公告)日：2017-06-01

申请号：US15349866

申请日：2016-11-11

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Julia Reid

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.