公开(公告)号：US10689453B2

公开(公告)日：2020-06-23

申请号：US16382645

申请日：2019-04-12

Applicant: Janssen Biotech, Inc

Inventor： John Chen ,  Johan Fransson ,  Natalie Fursov ,  Damon Hamel ,  Thomas Malia ,  Galina Obmolova ,  Tatiana Ort ,  Michael Rycyzyn ,  Michael Scully ,  Raymond Sweet ,  Alexey Teplyakov ,  John Wheeler ,  Juan Carlos Almagro

IPC: C07K16/28 ,  A61K39/00

Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.