公开(公告)号：US11130791B2

公开(公告)日：2021-09-28

申请号：US16196936

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Eric Gary Stefanich ,  Richard Vandlen ,  Philip E. Hass ,  Xiaoting Wang

IPC: C07K14/54 ,  C07K16/28 ,  A61K38/20 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US20190177390A1

公开(公告)日：2019-06-13

申请号：US16196936

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Ganesh A. Kolumam ,  Xiaoting Wang ,  Jed Ross ,  Nicholas Van Bruggen ,  Wyne P. Lee

IPC: C07K14/54 ,  A61K38/20 ,  A61K47/38 ,  C07K16/28

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10584155B2

公开(公告)日：2020-03-10

申请号：US15801867

申请日：2017-11-02

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Ganesh A. Kolumam ,  Xiaoting Wang ,  Jed Ross ,  Nicholas Van Bruggen ,  Wyne P. Lee

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US20190177387A1

公开(公告)日：2019-06-13

申请号：US16196743

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Ganesh A. Kolumam ,  Xiaoting Wang ,  Jed Ross ,  Nicholas Van Bruggen ,  Wyne P. Lee

IPC: C07K14/54 ,  A61K38/20 ,  A61K47/38 ,  C07K16/28

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10160793B2

公开(公告)日：2018-12-25

申请号：US14214161

申请日：2014-03-14

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US09512217B2

公开(公告)日：2016-12-06

申请号：US14148414

申请日：2014-01-06

Applicant: Genentech, Inc.

Inventor： Yongmei Chen ,  Yan (Helen) Hu ,  Wenjun Ouyang ,  Scott Stawicki ,  Yan Wu

IPC: A61K39/395 ,  C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention relates generally to antibodies cross-reactive with IL-17A and IL-17F, and bispecific anti-IL-17A/F and their uses.

Abstract translation: 本发明一般涉及与IL-17A和IL-17F交叉反应的抗体，以及双特异性抗IL-17A / F及其用途。

公开(公告)号：US20130302347A1

公开(公告)日：2013-11-14

申请号：US13900707

申请日：2013-05-23

Applicant: Genentech, Inc.

Inventor： Adrian Lobito ,  Wenjun Ouyang ,  Lino C. Gonzalez, JR.

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  C07K14/4743 ,  C07K14/65 ,  C07K14/70578 ,  C07K2317/76 ,  C07K2319/00

Abstract: Described herein is a novel receptor-ligand interaction and agents that may modify and/or block the interaction. Methods, uses, reagents and kits for the modulation of ligand activities related to its interaction with the novel receptor are disclosed. Also disclosed are therapeutic uses of reagents in treating inflammation-related disorders.

Abstract translation: 本文描述的是新的受体 - 配体相互作用和可以修饰和/或阻断相互作用的试剂。 公开了用于调节与其与新受体的相互作用相关的配体活性的方法，用途，试剂和试剂盒。 还公开了试剂治疗炎症相关疾病的治疗用途。