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公开(公告)号：US20220361844A1
公开(公告)日：2022-11-17
申请号：US17319741
申请日：2021-05-13
Applicant: General Electric Company
Inventor： David Andrew Shoudy , Craig Patrick Galligan , Weston Blaine Griffin , Jeffrey Michael Ashe , Warren Lee , James Enrico Sabatini
Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.
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公开(公告)号：US11311225B2
公开(公告)日：2022-04-26
申请号：US16027057
申请日：2018-07-03
Applicant: General Electric Company
Inventor： Azar Alizadeh , Andrew A. Burns , Matthew Jeremiah Misner , Ralf Lenigk , Jeffrey Michael Ashe , Obi Aghogho , Nancy Cecelia Stoffel , Juha Virtanen , Otto Pekander , Timo Toivanen , Robert Santala
Abstract: A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module.
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公开(公告)号：US20210228912A1
公开(公告)日：2021-07-29
申请号：US16750932
申请日：2020-01-23
Applicant: General Electric Company
Inventor： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
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公开(公告)号：US20210015454A1
公开(公告)日：2021-01-21
申请号：US16517289
申请日：2019-07-19
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , David Andrew Shoudy , Victoria Eugenia Cotero , James Enrico Sabatini
Abstract: Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.
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15.发明申请公开(公告)号：US20150094548A1
公开(公告)日：2015-04-02
申请号：US14039497
申请日：2013-09-27
Applicant: General Electric Company
Inventor： James Enrico Sabatini , Jeffrey Michael Ashe , Xiaohui Chen , Tzu-Jen Kao
CPC classification number: A61B5/0053 , A61B5/0537 , A61B5/4875 , A61B5/4878
Abstract: In accordance with one aspect of the present technique, a method is disclosed. The method includes applying a mechanical perturbation to a tissue region using a displacement device. The method further includes calculating a compression impedance of the tissue region in response to applying the mechanical perturbation. The method further includes retracting the displacement device and calculating a retraction impedance of the tissue region in response to retracting the displacement device. The method also includes determining a hydration level of the tissue region based on at least one of the compression impedance and the retraction impedances.
Abstract translation: 根据本技术的一个方面，公开了一种方法。 该方法包括使用位移装置将机械扰动施加到组织区域。 该方法还包括响应于施加机械扰动来计算组织区域的压缩阻抗。 该方法还包括回缩位移装置并响应于缩回位移装置计算组织区域的缩回阻抗。 该方法还包括基于压缩阻抗和回缩阻抗中的至少一个来确定组织区域的水化水平。
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Patent Agency Ranking
公开(公告)号：US20150002168A1
公开(公告)日：2015-01-01
申请号：US13929362
申请日：2013-06-27
Applicant: General Electric Company
Inventor： Tzu-Jen Kao , David Michael Davenport , Jeffrey Michael Ashe , Xiaohui Chen
IPC: G01R27/02
CPC classification number: A61B5/0536 , A61B5/4875 , A61B5/4878
Abstract: One system includes a pattern generator that generates one or more excitation patterns suitable for probing a hydration level of a tissue of a subject at one or more depths from a surface of the subject into an interrogation region. Each of the excitation patterns has a spatial sensitivity at one of the one or more predetermined depths. A data analysis module receives one or more measured responses of the subject at a plurality of electrodes to excitation applied by the plurality of electrodes based on the one or more excitation patterns and determines one or more hydration changes at the one or more depths within the subject based on the measured responses. Each of the measured responses corresponds to the one of the one or more predetermined depths for which the applied excitation pattern has spatial sensitivity.
Abstract translation: 一个系统包括图案发生器，其产生一个或多个激励图案，所述激励图案适于探测从被摄体表面到询问区域的一个或多个深度处的受试者的组织的水化水平。 每个激发图案在一个或多个预定深度中的一个处具有空间灵敏度。 数据分析模块基于一个或多个激励图案，在多个电极处接收受试者在多个电极处的一个或多个测量的响应，由多个电极施加的激励，并确定受试者内的一个或多个深度处的一个或多个水合变化 基于测量的响应。 每个测量的响应对应于所施加的激励图案具有空间灵敏度的一个或多个预定深度中的一个。
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公开(公告)号：US12257457B2
公开(公告)日：2025-03-25
申请号：US17864212
申请日：2022-07-13
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
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公开(公告)号：US20240115886A1
公开(公告)日：2024-04-11
申请号：US18481700
申请日：2023-10-05
Applicant: General Electric Company
Inventor： Christine A. Morton , Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero
IPC: A61N7/02
CPC classification number: A61N7/02 , A61N2007/0017
Abstract: The present approaches are generally directed to facilitating healing of wounds, including chronic wounds typically associated with slow heal times or which are persistent. In one embodiment, a method of promoting wound healing comprises positioning an ultrasound transducer at a stimulation site on a subject having a wound. Pulsed focused ultrasound (pFUS) is non-invasively applies using the transducer to cause modulation of a target anatomic site containing resident or circulating immune cells. Modulation of the target anatomic site of the subject causes migration of one or more of monocytes, macrophages, or neutrophils to a wound bed of the wound.
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公开(公告)号：US11602331B2
公开(公告)日：2023-03-14
申请号：US16567996
申请日：2019-09-11
Applicant: General Electric Company
Inventor： Asha Singanamalli , David Andrew Shoudy , Jeffrey Michael Ashe , Christopher Michael Puleo
Abstract: Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.
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公开(公告)号：US20200346043A1
公开(公告)日：2020-11-05
申请号：US16399692
申请日：2019-04-30
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
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