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公开(公告)号：US10125134B2
公开(公告)日：2018-11-13
申请号：US15814279
申请日：2017-11-15
发明人： James F. Blake , Laurence E. Burgess , Mark Joseph Chicarelli , James Gail Christensen , Jay Bradford Fell , John P. Fischer , John J. Gaudino , Erik James Hicken , Ronald Jay Hinklin , Matthew Randolf Lee , Matthew Arnold Marx , Macedonio J. Mejia , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P. A. Vigers , Henry J. Zecca
IPC分类号： C07D471/04 , C07D519/00 , A61K31/519
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US11932633B2
公开(公告)日：2024-03-19
申请号：US17053273
申请日：2019-05-06
发明人： Matthew Arnold Marx , Matthew Randolph Lee , James F. Blake , Mark Joseph Chicarelli , Jay Bradford Fell , John P. Fischer , Erik James Hicken , Pavel Savechenkov , Tony Tang , Guy P. A. Vigers , Henry J. Zecca
IPC分类号： C07D413/06 , A61P35/00 , C07D413/04 , C07D413/14 , C07D417/14
CPC分类号： C07D413/14 , A61P35/00 , C07D413/06
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20210380570A1
公开(公告)日：2021-12-09
申请号：US17053273
申请日：2019-05-06
发明人： Matthew Arnold Marx , Matthew Randolph Lee , James F. Blake , Mark Joseph Chicarelli , Jay Bradford Fell , John P. Fischer , Erik James Hicken , Pavel Savechenkov , Tony Tang , Guy P.A. Vigers , Henry J. Zecca
IPC分类号： C07D413/14 , C07D413/06 , A61P35/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20210230170A1
公开(公告)日：2021-07-29
申请号：US17272276
申请日：2019-08-29
发明人： Matthew Arnold Marx , James F. Blake , Jay Bradford Fell , John P. Fischer , Macedonio J. Mejia
IPC分类号： C07D487/04 , A61P35/00
摘要： The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20200331911A1
公开(公告)日：2020-10-22
申请号：US16917128
申请日：2020-06-30
发明人： Matthew Arnold Marx , James Gail Christensen , Christopher Ronald Smith , John P. Fischer , Aaron Craig Burns
IPC分类号： C07D471/04 , A61P35/00 , C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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![4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS](/abs-image/US/2019/06/13/US20190177328A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190177328A1
公开(公告)日：2019-06-13
申请号：US16212493
申请日：2018-12-06
发明人： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC分类号： C07D487/04 , A61K45/06 , A61K31/4985 , A61K31/5377
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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![4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors](/abs-image/US/2019/01/29/US10189845B2/abs.jpg.150x150.jpg)
公开(公告)号：US10189845B2
公开(公告)日：2019-01-29
申请号：US15532937
申请日：2015-12-04
发明人： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC分类号： A61K45/06 , C07D487/04 , A61K31/4985 , A61K31/5377
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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公开(公告)号：US20180072723A1
公开(公告)日：2018-03-15
申请号：US15814279
申请日：2017-11-15
发明人： James F. Blake , Laurence E. Burgess , Mark Joseph Chicarelli , James Gail Christensen , Jay Bradford Fell , John P. Fischer , John J. Gaudino , Erik James Hicken , Ronald Jay Hinklin , Matthew Randolf Lee , Matthew Arnold Marx , Macedonio J. Mejia , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Henry J. Zecca
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US11267812B2
公开(公告)日：2022-03-08
申请号：US16099398
申请日：2017-05-17
发明人： John P. Fischer , Jay Bradford Fell , James F. Blake , Ronald Jay Hinklin , Macedonio J. Mejia , Erik James Hicken , Mark Joseph Chicarelli , John J. Gaudino , Guy P. A. Vigers , Laurence E. Burgess , Matthew Arnold Marx , James Gail Christensen , Matthew Randolph Lee , Pavel Savechenkov , Henry J. Zecca , Tony P. Tang
IPC分类号： C07D471/04 , C07D519/00 , A61P35/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20190062330A1
公开(公告)日：2019-02-28
申请号：US16173726
申请日：2018-10-29
发明人： James F. Blake , Laurence E. Burgess , Mark Joseph Chicarelli , James Gail Christensen , Jay Bradford Fell , John P. Fischer , John J. Gaudino , Erik James Hicken , Ronald Jay Hinklin , Matthew Randolf Lee , Matthew Arnold Marx , Macedonio J. Mejia , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Henry J. Zecca
IPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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