公开(公告)号：US09453080B2

公开(公告)日：2016-09-27

申请号：US14407421

申请日：2013-06-11

Applicant: Amgen Inc.

Inventor： Huiquan Han ,  Xiaolan Zhou ,  Qing Chen ,  Mei-Mei Tsai

IPC: C07K16/28 ,  C12N15/13 ,  C12P21/08 ,  A61K39/395 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: This disclosure relates to antagonistic dual receptor antigen-binding proteins, e.g. antibodies and methods of using the dual receptor antibodies for treatment of pathological diseases. The dual receptor antibodies may comprise an antibody to ActRII receptors and may be used to treat pathological condition. The pathological conditions can comprise muscle wasting diseases or any disease that requires stimulation of muscle growth.

Abstract translation: 本公开涉及拮抗性双重受体抗原结合蛋白，例如 抗体和使用双重受体抗体治疗病理性疾病的方法。 双重受体抗体可以包含ActRII受体的抗体，并可用于治疗病理状态。 病理状况可能包括肌肉消瘦疾病或任何需要刺激肌肉生长的疾病。

公开(公告)号：US20150086556A1

公开(公告)日：2015-03-26

申请号：US14260856

申请日：2014-04-24

Applicant: Amgen Inc.

Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

Abstract translation: 本公开提供与抗激活素A结合蛋白（包括抗体）相关或衍生的组合物和方法。 在具体实施方案中，本公开提供了完整的人，人源化和嵌合的抗激活蛋白A抗体，其结合人激活素A，激活素A结合片段和此类抗体的衍生物，以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断具有激素A相关疾病或包括与性腺癌，其他癌症，类风湿性关节炎和其它疾病相关的恶病质的病症的受试者。