公开(公告)号：US10406182B2

公开(公告)日：2019-09-10

申请号：US15027424

申请日：2014-10-09

Applicant: RENEURON LIMITED

Inventor： Caroline Hicks ,  John Sinden ,  Lara Stevanato ,  Randolph Corteling

IPC: C12N15/113 ,  A61K35/30 ,  C12N5/0797 ,  A61K9/00

Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of cancer, typically a nestin-positive cancer. The cancer may be glioma, melanoma, breast cancer, pancreatic cancer or prostate cancer. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalized stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).

公开(公告)号：US20160235788A1

公开(公告)日：2016-08-18

申请号：US15027424

申请日：2014-10-09

Applicant: RENEURON LIMITED

Inventor： Caroline Hicks ,  John Sinden ,  Lara Stevanato ,  Randolph Corteling

IPC: A61K35/30 ,  C12N5/0797 ,  C12N15/113

CPC classification number: A61K35/30 ,  A61K9/0019 ,  C12N5/0623 ,  C12N15/113 ,  C12N2310/141 ,  C12N2501/15 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2502/088

Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of cancer, typically a nestin-positive cancer. The cancer may be glioma, melanoma, breast cancer, pancreatic cancer or prostate cancer. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).

Abstract translation: 本发明涉及从这些微粒分离的干细胞微粒和miRNA，其使用和生产，特别是神经干细胞微粒及其在癌症治疗中的用途，通常是巢蛋白阳性癌症。 癌症可能是胶质瘤，黑素瘤，乳腺癌，胰腺癌或前列腺癌。 干细胞微粒通常是外来体或微泡，并且可以衍生自神经干细胞系。 神经干细胞系可以是有条件永生化的干细胞系，例如CTX0E03（保藏在ECACC，登录号04091601）。

公开(公告)号：US09410122B2

公开(公告)日：2016-08-09

申请号：US14450733

申请日：2014-08-04

Applicant: RENEURON LIMITED

Inventor： John Sinden ,  Erik Miljan ,  Paolo Madeddu

IPC: A61K35/30 ,  C12N5/0797 ,  A61K35/12

CPC classification number: C12N5/0623 ,  A61K35/12 ,  A61K35/30 ,  C12N2510/04

Abstract: The present invention uses neural stem cells in the manufacture of a medicament for the treatment of a patient suffering peripheral arterial disease. The invention is particularly suited for treating limb ischemia or Buerger's disease.

公开(公告)号：US20230220344A1

公开(公告)日：2023-07-13

申请号：US17996329

申请日：2021-04-15

Applicant: ReNeuron Limited

Inventor： Steve PELLS ,  Marcela ROSAS ,  Randolph CORTELING

IPC: C12N5/0789 ,  C12N5/0783 ,  C12N15/90

CPC classification number: C12N5/0647 ,  C12N5/0636 ,  C12N15/907 ,  C12N2510/04 ,  C12N2506/45 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604

Abstract: The invention relates to induced pluripotent stem cells that are generated from cells, for example Adult Stem Cells, that are conditionally-immortalisable. In particular, the invention relates to induced pluripotent stem cells generated from stem cell lines comprising a controllable transgene for conditional immortalisation, and the progeny of those induced pluripotent stem cells such as cells of the haematopoietic lineage. Induced pluripotent stem cells, haematopoietic progeny cells derived from those pluripotent cells, compositions comprising those cells, methods of making all of those cells, and uses of all of those cells are also described.

公开(公告)号：US20190388475A1

公开(公告)日：2019-12-26

申请号：US16554388

申请日：2019-08-28

Applicant: Reneuron Limited

Inventor： John Sinden ,  Lara Stevanato ,  Randolph Corteling

IPC: A61K35/30 ,  G01N33/50 ,  C12N15/113

Abstract: This invention relates to stem cell microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTXOE03 (deposited at the ECACC with Accession No. 04091601).

公开(公告)号：US20190381105A1

公开(公告)日：2019-12-19

申请号：US16521298

申请日：2019-07-24

Applicant: RENEURON LIMITED

Inventor： CAROLINE HICKS ,  JOHN SINDEN ,  LARA STEVANATO ,  RANDOLPH CORTELING

IPC: A61K35/30 ,  C12N5/0797 ,  C12N15/113

Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of cancer, typically a nestin-positive cancer. The cancer may be glioma, melanoma, breast cancer, pancreatic cancer or prostate cancer. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).

公开(公告)号：US20150366897A1

公开(公告)日：2015-12-24

申请号：US14767278

申请日：2014-02-12

Applicant: RENEURON LIMITED

Inventor： Lara Stevanato ,  Randolph Corteling ,  John Sinden

IPC: A61K31/7105

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K35/30 ,  A61K2300/00

Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601). Identified miRNAs include hsa-miR-1246, hsa-miR-4492, hsa-miR-4488 and hsa-miR-4532.

Abstract translation: 本发明涉及从这些微粒分离的干细胞微粒和miRNA，其使用和生产，特别是神经干细胞微粒及其在治疗中的应用。 干细胞微粒通常是外来体或微泡，并且可以衍生自神经干细胞系。 神经干细胞系可以是有条件永生化的干细胞系，例如CTX0E03（保藏在ECACC，登录号04091601）。 鉴定的miRNA包括hsa-miR-1246，hsa-miR-4492，hsa-miR-4488和hsa-miR-4532。