公开(公告)号：US5972998A

公开(公告)日：1999-10-26

申请号：US76591

申请日：1998-05-12

Applicant: Michel J. Jung ,  Mahinda Wickramaratne ,  Michael Hepperle

Inventor： Michel J. Jung ,  Mahinda Wickramaratne ,  Michael Hepperle

IPC: C07D307/92 ,  C07D493/04 ,  C07D493/08 ,  C07D493/10 ,  C07D493/20 ,  A61K31/34 ,  C07D407/00

CPC classification number: C07D307/92 ,  C07D493/04 ,  C07D493/08 ,  C07D493/10

Abstract: The present invention relates to novel triptolide derivatives and a method of treating a patient suffering from an autoimmune disease comprising administering to a patient an effective amount of the novel triptolide derivatives.

公开(公告)号：US20070207997A1

公开(公告)日：2007-09-06

申请号：US11706760

申请日：2007-02-15

Applicant: Michael Hepperle ,  Julie Liu ,  R. Rowland ,  Dilrukshi Vitharana

Inventor： Michael Hepperle ,  Julie Liu ,  R. Rowland ,  Dilrukshi Vitharana

IPC: A61K31/55 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: This invention provides alpha-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, and x are as described in the specification. The compounds are useful for treating inflammatory diseases and cancer.

Abstract translation: 本发明提供了式I的α-咔啉化合物：其中R 1，R 2，R 3，R 4， >，R 5，和x如说明书中所述。 该化合物可用于治疗炎性疾病和癌症。

公开(公告)号：US06514977B1

公开(公告)日：2003-02-04

申请号：US09196623

申请日：1998-11-20

Applicant: Ashok Anantanarayan ,  Michael Clare ,  Paul W. Collins ,  Joyce Zuowu Crich ,  Rajesh Devraj ,  Daniel L. Flynn ,  Lifeng Geng ,  Matthew J. Graneto ,  Cathleen E. Hanau ,  Gunnar J. Hanson ,  Susan J. Hartmann ,  Michael Hepperle ,  He Huang ,  Francis J. Koszyk ,  Shuyuan Liao ,  Suzanne Metz ,  Richard A. Partis ,  Thao D. Perry ,  Shashidhar N. Rao ,  Shaun Raj Selness ,  Michael S. South ,  Michael A. Stealey ,  John Jeffrey Talley ,  Michael L. Vazquez ,  Richard M. Weier ,  Xiangdong Xu ,  Ish K. Khanna ,  Yi Yu

Inventor： Ashok Anantanarayan ,  Michael Clare ,  Paul W. Collins ,  Joyce Zuowu Crich ,  Rajesh Devraj ,  Daniel L. Flynn ,  Lifeng Geng ,  Matthew J. Graneto ,  Cathleen E. Hanau ,  Gunnar J. Hanson ,  Susan J. Hartmann ,  Michael Hepperle ,  He Huang ,  Francis J. Koszyk ,  Shuyuan Liao ,  Suzanne Metz ,  Richard A. Partis ,  Thao D. Perry ,  Shashidhar N. Rao ,  Shaun Raj Selness ,  Michael S. South ,  Michael A. Stealey ,  John Jeffrey Talley ,  Michael L. Vazquez ,  Richard M. Weier ,  Xiangdong Xu ,  Ish K. Khanna ,  Yi Yu

IPC: A61K31454

CPC classification number: C07D409/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.

公开(公告)号：US20050020594A1

公开(公告)日：2005-01-27

申请号：US10893073

申请日：2004-07-16

Applicant: Michael Hepperle ,  Kevin Jerome ,  John Walker ,  Shaun Selness ,  Rajesh Devraj

Inventor： Michael Hepperle ,  Kevin Jerome ,  John Walker ,  Shaun Selness ,  Rajesh Devraj

IPC: A61K31/501 ,  C07D237/14 ,  C07D237/16 ,  C07D237/18 ,  C07D237/22 ,  C07D405/12 ,  C07

CPC classification number: C07D405/12 ,  C07D237/14 ,  C07D237/16 ,  C07D237/18 ,  C07D237/22

Abstract: Disclosed are substituted pyridazinones that are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical composition containing the pyridazinone compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract translation: 公开了可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加剧的疾病和病症的取代哒嗪酮。 还公开了含有哒嗪酮化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。