公开(公告)号：US07345085B2

公开(公告)日：2008-03-18

申请号：US11714341

申请日：2007-03-06

申请人： John J. Acton, III ,  Sheryl D. Debenham ,  Kun Liu ,  Peter T. Meinke ,  Harold B. Wood ,  Regina M. Black

发明人： John J. Acton, III ,  Sheryl D. Debenham ,  Kun Liu ,  Peter T. Meinke ,  Harold B. Wood ,  Regina M. Black

IPC分类号： A61K31/40 ,  C07D209/36

CPC分类号： C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04

摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

公开(公告)号：US07186746B2

公开(公告)日：2007-03-06

申请号：US10524697

申请日：2003-08-27

申请人： John J. Acton, III ,  Sheryl D. Debenham ,  Kun Liu ,  Peter T. Meinke ,  Harold B. Wood ,  Regina M. Black

发明人： John J. Acton, III ,  Sheryl D. Debenham ,  Kun Liu ,  Peter T. Meinke ,  Harold B. Wood ,  Regina M. Black

IPC分类号： A61K31/40 ,  C07D209/36

CPC分类号： C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/04

摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

摘要翻译： 具有芳氧基链烷酸取代基或芳基链烷酸取代基的吲哚是PPARγ的激动剂或部分激动剂，并且可用于治疗和控制II型糖尿病症状的高血糖，以及血脂异常，高脂血症，高胆固醇血症，高甘油三酯血症和肥胖症 经常与2型糖尿病有关。