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111.发明申请公开(公告)号：US20120178650A1
公开(公告)日：2012-07-12
申请号：US13416968
申请日：2012-03-09
Applicant: Gregory T. Carroll , Jeffrey T. Koberstein , Denong Wang , Nicholas J. Turro
Inventor： Gregory T. Carroll , Jeffrey T. Koberstein , Denong Wang , Nicholas J. Turro
IPC: C40B40/08 , C07F7/18 , C40B40/04 , B05D5/00 , C40B40/10 , C40B40/14 , G03F7/20 , B05D3/06 , C07D403/06 , C40B40/12
CPC classification number: C07C49/303 , B05D3/06 , B05D3/067 , B05D5/00 , B05D7/02 , B05D7/14 , C07C69/76 , C07D209/48 , C23C18/1612 , C23C18/1641 , C23C18/30 , C23C18/32 , G03F7/0045 , G03F7/20
Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.
Abstract translation: 描述了用于控制表面性质的化合物和方法。 本发明的化合物可以在暴露于辐射下形成自由基，然后其可以与附近的分子反应以改变各种底物的表面性质。 本发明可以提供耐脱湿的表面，具有固定化分子的表面，例如碳水化合物和聚合物固定的表面，以及在表面上沉积金属的表面。 本发明可以用于广泛的应用，例如传感器，微反应器，微阵列，金属的无电沉积等。
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112.发明申请
公开(公告)号：US20120172402A1
公开(公告)日：2012-07-05
申请号：US13383266
申请日：2010-07-09
Applicant: Hans-Günther Schmalz , Ronald Kuhne , Verena Hack , Cédric Reuter
Inventor： Hans-Günther Schmalz , Ronald Kuhne , Verena Hack , Cédric Reuter
IPC: A61K31/429 , C07K1/107 , C40B50/00 , C40B40/10 , C07D498/18 , C07D487/18 , A61K31/424 , A61K31/407 , A61P35/00 , A61P25/28 , A61P31/12 , A61P31/04 , C07K2/00 , C07K14/00 , C07D513/18
CPC classification number: C07D487/18
Abstract: Substituted tricyclic diproline analogues of the formula (I): wherein the variables are as defined herein. Also disclosed are methods for the production thereof, the use thereof for the induction of an alpha-helix conformation in peptides and/or proteins, pharmaceuticals containing said compounds, methods for the production of a peptide library containing said compounds, and peptide libraries containing said compounds.
Abstract translation: 取代的式（I）的三环二叠氮类似物：其中变量如本文所定义。 还公开了其生产方法，其用于在肽和/或蛋白质中诱导α-螺旋构象的用途，含有所述化合物的药物，含有所述化合物的肽文库的制备方法和含有所述化合物的肽文库 化合物。
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113.发明申请METHOD FOR A HIGHLY SENSITIVE DETECTION AND QUANTIFICATION OF BIOMOLECULES USING SECONDARY ION MASS SPECTROMETRY (SIMS) 审中-公开使用二次离子质谱法（SIMS）对生物分子敏感检测和定量的方法
公开(公告)号：US20120172249A1
公开(公告)日：2012-07-05
申请号：US13395238
申请日：2010-09-15
Applicant: Camille Ripoll , Victor Norris , Guillaume Legent , Anthony Delaune
Inventor： Camille Ripoll , Victor Norris , Guillaume Legent , Anthony Delaune
CPC classification number: G01N33/6848 , B01J2219/00527 , B01J2219/00619 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , C12Q1/02 , C12Q1/6837 , C40B20/02 , C40B20/08 , G01N33/50 , G01N2458/15
Abstract: The present invention relates to an improved method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the SIMS technique and arrays for use in said method.
Abstract translation: 本发明涉及使用所述方法中使用的SIMS技术和阵列来检测和定量样品中存在或不存在多种生物分子的改进方法。
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114.发明申请Loop-Variant Pdz Domains As Biotherapeutics, Diagnostics And Research Reagents 审中-公开环形变体Pdz域作为生物治疗，诊断和研究试剂
公开(公告)号：US20120171122A1
公开(公告)日：2012-07-05
申请号：US13415490
申请日：2012-03-08
Applicant: Simon Delagrave
Inventor： Simon Delagrave
IPC: A61K49/00 , C12N15/11 , C40B30/04 , C12N1/21 , C12N1/19 , A61P31/00 , C12N5/10 , G01N33/53 , A61K38/16 , C40B40/10 , C40B40/08 , C07K14/00 , C12N1/15
Abstract: The present invention provides polypeptides that contain one or more PDZ loop-variants and are useful in the detection of pathogens and disease-associated molecules. The polypeptides of the invention are also useful in the diagnosis, treatment, and prevention of diseases. Also provided are methods of preparing polypeptides of the invention.
Abstract translation: 本发明提供含有一个或多个PDZ环变体并且可用于检测病原体和疾病相关分子的多肽。 本发明的多肽也可用于诊断，治疗和预防疾病。 还提供了制备本发明多肽的方法。
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公开(公告)号：US20120129717A1
公开(公告)日：2012-05-24
申请号：US13299367
申请日：2011-11-18
Applicant: Stefanie Urlinger , Thomas Tiller , Ingrid Schuster , Yvonne Stark
Inventor： Stefanie Urlinger , Thomas Tiller , Ingrid Schuster , Yvonne Stark
CPC classification number: G01N33/6854 , C07K16/005 , C07K2317/55 , C07K2317/567 , C12N15/1037 , C40B40/08
Abstract: The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties relevant to developability, wherein the collections may be used to select against any antigen using, for example, phage display.
Abstract translation: 本公开使得可变重链和可变轻链对的收集部分包含预先选择用于与显影性相关的功能性质的种系蛋白序列，其中所述集合可以用于使用例如， 噬菌体展示。
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116.发明申请ANTIBODIES DIRECTED TO TRA ANTIGENS, AND METHODS OF PRODUCTION, SCREENING AND ANALYSIS OF SAID ANTIBODIES, AS WELL AS METHODS OF ANALYSIS OF STEM CELLS AND CANCER CELL 审中-公开抗TRA抗原的抗体以及抗体的生产，筛选和分析方法，以及作为干细胞和癌细胞分析的方法
公开(公告)号：US20120129712A1
公开(公告)日：2012-05-24
申请号：US13266090
申请日：2010-04-26
Applicant: Tero Satomaa , Suvi Natunen , Leena Valmu , Jari Natunen
Inventor： Tero Satomaa , Suvi Natunen , Leena Valmu , Jari Natunen
CPC classification number: C07H5/06 , C07H13/04 , C07K16/44 , G01N33/5005 , G01N33/574 , G01N2400/38
Abstract: A complex of Tra-antibody bound to an isolated glycan comprising type I—N-acetyllactosamine comprising target structure, and methods and uses utilizing said complex.
Abstract translation: 包含目标结构的包含I-N-乙酰基乳糖胺的分离聚糖的Tra-抗体复合物，以及利用所述复合物的方法和用途。
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117.发明申请
公开(公告)号：US20120122736A1
公开(公告)日：2012-05-17
申请号：US13201181
申请日：2010-02-11
Applicant: R. Michael Angelo , April S. Brown , Scott Wolter , William V. Lampert
Inventor： R. Michael Angelo , April S. Brown , Scott Wolter , William V. Lampert
CPC classification number: G01N33/5438 , Y10T29/41
Abstract: A sensor comprising an electronic circuit electrically coupled to a type III-V semiconductor material, for example indium arsenide (InAs) and an antibody contacting the type III-V semiconductor material. The sensor produces measurable N changes in the electrical properties of the semiconductor upon antibody-antigen binding events. Electrical properties measurable by the electronic device may include resistivity, capacitance, impedance, and inductance. A method of detecting an antigen using sensors of the invention. A method of detecting a reaction of an analyte to a stimulus using sensors of the invention. Sensor arrays comprising multiple sensors of the invention.
Abstract translation: 一种传感器，包括电耦合到III-V族半导体材料的电子电路，例如砷化铟（InAs）和与III-V族半导体材料接触的抗体。 传感器在抗体 - 抗原结合事件时产生半导体电性能的可测量的N变化。 电子设备可测量的电气特性可包括电阻率，电容，阻抗和电感。 使用本发明的传感器检测抗原的方法。 使用本发明的传感器检测分析物与刺激物的反应的方法。 传感器阵列包括本发明的多个传感器。
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公开(公告)号：US20120122726A1
公开(公告)日：2012-05-17
申请号：US13386536
申请日：2010-07-23
Applicant: Miguel Abal Posada , Andreas Doll , Antonio Gil Moreno , Tamara Maes , Cristina Perez , Jaume Reventós Puigjaner , Elisabet Rossell
Inventor： Miguel Abal Posada , Andreas Doll , Antonio Gil Moreno , Tamara Maes , Cristina Perez , Jaume Reventós Puigjaner , Elisabet Rossell
CPC classification number: G01N33/57442 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2800/60
Abstract: The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals.
Abstract translation: 本发明涉及令人惊奇的发现：对应于ACAA1，AP1M2，CGN，DDR1，EPS8L2，FASTKD1，GMIP，IKBKE，P2RX4，P4HB，PHKG2，PPFIBP2，PPP1R16A，RASSF7，RNF183，SIRT6，TJP3，EFEMP2，S0CS2， 与对照样品相比，DCN与子宫内膜癌患者相比差异表达，因此可用于检测子宫内膜癌。 特别地，这些具有优异的敏感性，特异性和/或分离受影响的非受影响个体的能力的生物标志物。 此外，发明人发现与对照值相比，这些生物标志物在原发性子宫内膜癌肿瘤组织中的差异表达与子宫液样品中的表达水平相关。 因此，这些生物标志物是稳健的，因为它们被发现在受影响个体的几种不同类型的样品中差异表达。
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公开(公告)号：US20120122711A1
公开(公告)日：2012-05-17
申请号：US13384510
申请日：2010-07-15
Applicant: James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo , Yi Li Ang , Yiran Zhang
Inventor： James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo , Yi Li Ang , Yiran Zhang
CPC classification number: G01N33/6845
Abstract: Described herein are inventive compositions and methods relating to sampling of biopolymers and, in particular, to fractional sampling of biopolymers. In one aspect, embodiments are generally related to unique biopolymer species where a fraction of each biopolymer species contains a cleavable linker. The biopolymer species may, in some embodiments, be attached to a surface. For example, the biopolymer species may be attached to beads. In some embodiments, a portion of a unique biopolymer species may be sampled by cleaving the cleavable linker. In some cases, the sample may be analyzed to determine the sequence of the biopolymer.
Abstract translation: 本文描述了与生物聚合物的取样有关的本发明组合物和方法，特别是生物聚合物的分数取样。 在一个方面，实施方案通常涉及独特的生物聚合物种类，其中每个生物聚合物种类的一部分含有可切割的连接体。 在一些实施方案中，生物聚合物物质可附着于表面。 例如，生物聚合物物质可以连接到珠粒上。 在一些实施方案中，可以通过切割可切割接头来采样一部分独特的生物聚合物种类。 在一些情况下，可以分析样品以确定生物聚合物的顺序。
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公开(公告)号：US20120108791A1
公开(公告)日：2012-05-03
申请号：US13263886
申请日：2010-04-20
Applicant: Roland Dunbrack , Maxim Shapovalov
Inventor： Roland Dunbrack , Maxim Shapovalov
Abstract: Rotamer libraries and methods of use thereof are provided.
Abstract translation: 提供了Rotamer文库及其使用方法。
