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公开(公告)号：US08343461B2
公开(公告)日：2013-01-01
申请号：US12201662
申请日：2008-08-29
Applicant: Waldemar Debinski , Jill Wykosky , Denise Gibo
Inventor： Waldemar Debinski , Jill Wykosky , Denise Gibo
IPC: A61K49/00 , A61K51/00 , A61B10/00 , G01N33/53 , G01N33/574
CPC classification number: A61K38/177 , A61K38/00 , A61K38/2086 , A61K38/45 , A61K45/06 , A61K47/64 , A61K47/642 , A61K47/6801 , A61K49/0002 , C07K14/52 , C07K14/705 , C12Y204/02036
Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
Abstract translation: 本发明提供了用于检测，诊断和治疗多形性胶质母细胞瘤等癌症的化合物，组合物和方法。
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公开(公告)号：US20120289688A1
公开(公告)日：2012-11-15
申请号：US13500244
申请日：2010-10-07
Applicant: Normand Blais , Philippe Marc Helene Dehottay , Marianne Dewerchin , Philippe Goffin , Denis Martin
Inventor： Normand Blais , Philippe Marc Helene Dehottay , Marianne Dewerchin , Philippe Goffin , Denis Martin
IPC: C12N15/62
CPC classification number: C07K14/34 , C07K1/00 , C07K2319/034 , C12N9/1077 , C12Y204/02036
Abstract: Polynucleotides are provided herein.
Abstract translation: 本文提供多核苷酸。
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公开(公告)号：US20120189540A1
公开(公告)日：2012-07-26
申请号：US13439453
申请日：2012-04-04
Applicant: Ivan Bergstein
Inventor： Ivan Bergstein
IPC: A61K39/395 , A61P35/02 , A61P35/00 , A61K51/00 , C07K16/28
CPC classification number: C07K16/2866 , A61K39/00 , C07K16/18 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/55 , C12N5/163 , C12N9/1048 , C12N9/1077 , C12N15/86 , C12Y204/02036
Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3Rα-expressing cell population, the methods comprising contacting a population of IL3Rα-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3Rα. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3Rα chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3Rα-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3Rα.
Abstract translation: 本发明提供了结合IL-3受体α亚基α（II3Rα）链的抗体和包含此类抗体的组合物。 本发明提供了抑制或减少IL3Rα表达细胞群体的方法，所述方法包括将IL3Rα表达细胞群（例如癌细胞和/或癌干细胞）与结合IL3Rα的抗体接触。 本发明还提供了包含结合与细胞毒剂或抗细胞剂连接的IL3Rα链的抗体的抗体缀合物和包含这种缀合物的组合物。 本发明还提供了用于预防，治疗和/或控制与表达IL3Rα的细胞相关的病症（例如，血液癌症）的方法，所述方法包括向有需要的受试者施用与IL3Rα结合的抗体。
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公开(公告)号：US20110020344A1
公开(公告)日：2011-01-27
申请号：US12934214
申请日：2009-04-01
Applicant: Dimiter S. Dimitrov , Xiaodong Xiao , Ira H. Pastan
Inventor： Dimiter S. Dimitrov , Xiaodong Xiao , Ira H. Pastan
IPC: A61K39/395 , C07K16/28 , C07H21/00 , C12N15/63 , G01N33/574 , C12N5/10 , A61P35/00 , A61P35/02
CPC classification number: C07K16/2803 , A61K38/164 , A61K38/45 , A61K39/00 , A61K39/39558 , A61K47/6829 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/28 , C07K16/2896 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12Y204/02036 , G01N33/57492 , G01N2333/70503
Abstract: Disclosed herein are isolated human monoclonal antibodies that specifically bind human CD22 with a dissociation constant (Kd) of 25 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect human CD22 in a sample. In some cases, CD22 is soluble CD22. Methods of diagnosing a B-cell malignancy, or confirming a B-cell malignancy diagnosis, are disclosed herein that utilize these antibodies. Methods of treating a subject with a B-cell malignancy are also disclosed.
Abstract translation: 本文公开了分离的人单克隆抗体，其具有25nM或更低的解离常数（Kd）特异性结合人CD22。 还公开了编码这些抗体的核酸，包括这些核酸分子的表达载体和表达核酸分子的分离的宿主细胞。 抗体可用于检测样品中的人CD22。 在某些情况下，CD22是可溶性CD22。 本文公开了利用这些抗体的诊断B细胞恶性肿瘤或确认B细胞恶性肿瘤诊断的方法。 还公开了治疗患有B细胞恶性肿瘤的受试者的方法。
