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公开(公告)号：US08940310B2
公开(公告)日：2015-01-27
申请号：US13704978
申请日：2011-06-16
Applicant: Franck Barrat , Robert L. Coffman , Cristiana Guiducci
Inventor： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
IPC: A61K31/7125 , A01N43/04 , C12N15/117
CPC classification number: C12N15/117 , A61K31/573 , A61K31/7125 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2320/30 , C12N2320/31 , Y02A50/411 , C12N2310/3521
Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
Abstract translation: 本申请涉及调节包含TLR7和/或TLR9抑制剂的免疫应答的组合物和方法，例如免疫调节多核苷酸和/或免疫调节化合物。 本申请还涉及用于预测和/或确定疾病对包括TLR7和/或TLR9抑制剂的治疗反应性的组合物和方法。
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92.发明授权
公开(公告)号：US08871732B2
公开(公告)日：2014-10-28
申请号：US13438757
申请日：2012-04-03
Applicant: Dino Dina , Karen L. Fearon , Jason Marshall
Inventor： Dino Dina , Karen L. Fearon , Jason Marshall
CPC classification number: C12N15/117 , A61K39/0011 , A61K45/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/17 , C12N2310/315 , C12N2310/333 , C12N2310/335 , C12N2310/336
Abstract: The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
Abstract translation: 本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。
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公开(公告)号：US08835108B2
公开(公告)日：2014-09-16
申请号：US13839023
申请日：2013-03-15
Inventor： Katalin Kariko , Drew Weissman
IPC: C12Q1/68 , C07H21/02 , A61K48/00 , C12N15/67 , C12N15/117 , C07K14/47 , C07K14/505
CPC classification number: A61K48/0066 , A61K38/177 , A61K38/1816 , A61K38/50 , A61K48/00 , A61K48/0041 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/47 , C07K14/4712 , C07K14/505 , C12N15/117 , C12N15/67 , C12N15/85 , C12N2310/17 , C12N2310/33 , C12N2310/3341 , C12N2800/95 , C12Q1/68 , C12Y305/04004
Abstract: This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.
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公开(公告)号：US20140134233A1
公开(公告)日：2014-05-15
申请号：US14026995
申请日：2013-09-13
Applicant: The Government of the United States of America as represented by the Secretary of the Department of
Inventor： Dennis M. Klinman , Rainald Zeuner , Mayda Gursel , Ihsan Gursel , Daniela Verthelyi
IPC: C12N15/117 , A61K45/06 , A61K31/7125
CPC classification number: C12N15/117 , A61K31/7125 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315 , C12N2310/3515
Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
Abstract translation: 本公开涉及抑制免疫应答的寡脱氧核苷酸。 公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来预防或治疗免疫介导的病症，例如但不限于自身免疫性疾病的方法。 还公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来抑制受试者的免疫应答的方法。
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公开(公告)号：US08680069B2
公开(公告)日：2014-03-25
申请号：US13897367
申请日：2013-05-18
Applicant: Moderna Therapeutics
Inventor： Antonin de Fougerolles , Kristy M. Wood , Sayda M. Elbashir , Jason P. Schrum
IPC: C12N15/117 , A61K48/00
CPC classification number: A61K38/193 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/1271 , A61K9/1272 , A61K9/14 , A61K9/16 , A61K9/1647 , A61K31/7088 , A61K31/7105 , A61K38/4833 , A61K48/00 , A61K48/0033 , A61K48/0041 , A61K48/005 , A61K48/0066 , C07K2/00 , C07K14/535 , C12N15/00 , C12N15/117 , C12N15/88 , C12P21/00
Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
Abstract translation: 本公开尤其提供包含修饰的核酸分子的制剂组合物，其可以编码蛋白质，蛋白质前体或部分或完全加工形式的蛋白质或蛋白质前体。 制剂组合物还可包含经修饰的核酸分子和递送剂。 本发明还提供了用于编码能够调节细胞功能和/或活性的多肽的核酸。
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公开(公告)号：US08168201B2
公开(公告)日：2012-05-01
申请号：US11696131
申请日：2007-04-03
Applicant: Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
Inventor： Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
IPC: A61K39/295 , A61K48/00 , A61K39/02 , C12N15/117 , A61K38/00
CPC classification number: A61K39/385 , A61K39/012 , A61K39/08 , A61K2039/552 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C07K2319/55 , C12N2720/10034 , C12N2760/18434 , C12N2770/20034 , Y02A50/489
Abstract: The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.
Abstract translation: 本发明涉及用于诱导免疫应答的组合物，包括抗原和混杂T细胞表位。 还提供了在宿主中诱导免疫应答的方法，包括向宿主施用包含抗原和混杂的T细胞表位的组合物。
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公开(公告)号：US06949520B1
公开(公告)日：2005-09-27
申请号：US09672126
申请日：2000-09-27
Applicant: Gunther Hartmann , Robert L. Bratzler , Arthur M. Krieg
Inventor： Gunther Hartmann , Robert L. Bratzler , Arthur M. Krieg
IPC: A61K38/21 , A61K39/00 , C12N5/0784 , C12N15/117 , A61K31/70 , C12N15/63
CPC classification number: C12N15/117 , A61K38/21 , A61K2039/5154 , A61K2039/5158 , A61K2039/55561 , C12N5/0639 , C12N2501/056 , C12N2501/22 , C12N2501/23 , A61K2300/00
Abstract: Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
Abstract translation: 提供了方法和组合物，用于延长IFN-α在治疗各种病毒和增殖性疾病中的临床效用。 在其它方面，本发明提供了增加IFN-α治疗功效并降低IFN-α治疗相关副作用的方法。 此外，提供了用于在体外支持生存和激活天然干扰素产生细胞（IPC）的方法，而没有外源IL-3或GM-CSF的方法。 本发明基于某些CpG和非CpG ISNA促进IPC的存活和刺激的发现。
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公开(公告)号：US20050049216A1
公开(公告)日：2005-03-03
申请号：US10894862
申请日：2004-07-16
Applicant: Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
Inventor： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
IPC: C12N15/09 , A61K9/127 , A61K31/00 , A61K31/175 , A61K31/335 , A61K31/47 , A61K31/4706 , A61K31/70 , A61K31/7088 , A61K39/39 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/52 , C12N15/117 , C12Q1/68
CPC classification number: A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
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公开(公告)号：US20050032736A1
公开(公告)日：2005-02-10
申请号：US10888785
申请日：2004-07-09
Applicant: Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
Inventor： Arthur Krieg , Joel Kline , Dennis Klinman , Alfred Steinberg
IPC: C12N15/09 , A61K9/127 , A61K31/00 , A61K31/175 , A61K31/335 , A61K31/47 , A61K31/4706 , A61K31/70 , A61K31/7088 , A61K39/39 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P11/06 , A61P17/06 , A61P19/02 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/52 , C12N15/117 , C12Q1/68
CPC classification number: A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
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100.发明授权Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states 失效使用多核苷酸，寡核苷酸及其衍生物治疗各种疾病状态的方法
公开(公告)号：US5977083A
公开(公告)日：1999-11-02
申请号：US465352
申请日：1995-06-05
Applicant: Arsinur Burcoglu
Inventor： Arsinur Burcoglu
CPC classification number: A61K31/70 , A61K31/711 , C12N15/117 , A61K38/00 , C12N2310/18
Abstract: Oligodeoxyribonucleotides, polydeoxyribonucleotides and derivatives thereof, such as defibrotide, are agents of genetic modulation at the levels of transcription, translation, secondary messengers and cellular signal transduction systems. Various disease states can be treated by modifying the dose of such agents in response to observed fluctuations (e.g., increase, decrease, appearance, disappearance) in normal, disease and repair markers.
Abstract translation: 寡脱氧核糖核苷酸，多脱氧核糖核苷酸及其衍生物，如去纤维蛋白肽，是转录，翻译，第二信使和细胞信号转导系统水平的遗传调节剂。 可以通过根据正常，疾病和修复标记物中观察到的波动（例如增加，减少，外观，消失）改变这些药剂的剂量来治疗各种疾病状态。
