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    Certain pyrrolyl-substituted hydroxamic acid derivatives
    91.
    发明授权
    Certain pyrrolyl-substituted hydroxamic acid derivatives 失效
    某些吡咯基取代的异羟肟酸衍生物

    公开(公告)号：US4960787A

    公开(公告)日：1990-10-02

    申请号：US306975

    申请日：1989-02-06

    Applicant: Jan W. F. Wasley

    Inventor： Jan W. F. Wasley

    IPC: C07D207/32 ,  C07D207/327 ,  C07D207/34

    CPC classification number: C07D207/327 ,  C07D207/34

    Abstract: The invention relates to the pyrrolyl-substituted hydroxamic acid derivatives of the formula ##STR1## wherein R represents aryl, aryl-lower alkyl, cycloalkyl, bicycloalkyl or adamantyl; R.sub.1 and R.sub.2 represent hydrogen or lower alkyl; Y represents a direct bond, lower alkylene, lower alkenylene or lower alkadienylene; Z represents ##STR2## wherein R.sub.3 represents hydrogen or acyl; R.sub.4 represents lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, aryl or aryl-lower alkyl; or Z represents ##STR3## wherein R.sub.3 represents hydrogen or acyl; R.sub.5 represents lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, aryl, aryl-lower alkyl, amino or N-(mono- or di-lower alkyl)-amino; R.sub.6 and R.sub.7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof provided that R.sub.3 represents hydrogen; which are useful as lipoxygenase inhibitors.

    Abstract translation: 本发明涉及式（I）的吡咯基取代的异羟肟酸衍生物，其中R代表芳基，芳基 - 低级烷基，环烷基，双环烷基或金刚烷基; R1和R2表示氢或低级烷基; Y表示直接键，低级亚烷基，低级亚烯基或低级亚二烯基; Z代表（a）其中R3代表氢或酰基; R 4表示低级烷基，C 3 -C 7 - 环烷基，芳基或芳基 - 低级烷基; 或Z表示（b）其中R3表示氢或酰基; R 5表示低级烷基，C 3 -C 7 - 环烷基，芳基，芳基 - 低级烷基，氨基或N-（单 - 或二 - 低级烷基） - 氨基; R6和R7代表氢或低级烷基; 其药学上可接受的盐，其中R3表示氢; 它们可用作脂氧合酶抑制剂。

    Bis[4-(3,4-dimethylene-pyrrolidyl)phenyl] methane
    95.
    发明授权
    Bis[4-(3,4-dimethylene-pyrrolidyl)phenyl] methane 失效
    双[4-（3,4-二甲基 - 吡咯烷基）苯基]甲烷

    公开(公告)号：US4895915A

    公开(公告)日：1990-01-23

    申请号：US311551

    申请日：1989-02-16

    Applicant: Raphael M. Ottenbrite

    Inventor： Raphael M. Ottenbrite

    IPC: C07D207/32 ,  C07D207/325 ,  C08G73/12

    CPC classification number: C07D207/325 ,  C08G73/12

    Abstract: A polyimide composition consisting essentially of recurring units having the following structural formula: ##STR1## is produced by the copolymerization of a bismaleimide and bis[4-(3,4-dimethylenepyrrolidyl)phenyl] methane.

    Abstract translation: 主要由具有以下结构式的重复单元组成的聚酰亚胺组合物：通过双马来酰亚胺和双[4-（3,4-二甲基甲酰吡咯烷基）苯基]甲烷的共聚合产生。

    Pyrrolacetic amides having antiinflammatory activity
    96.
    发明授权
    Pyrrolacetic amides having antiinflammatory activity 失效
    具有抗炎活性的吡咯乙酰胺

    公开(公告)号：US4882349A

    公开(公告)日：1989-11-21

    申请号：US700059

    申请日：1985-02-11

    Applicant: Alessandro Baglioni

    Inventor： Alessandro Baglioni

    IPC: A61K31/40 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/495 ,  A61K31/535 ,  A61P11/14 ,  A61P25/04 ,  A61P29/00 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D401/12

    CPC classification number: C07D207/337 ,  C07D401/12

    Abstract: N-monosubstituted and N,N-disubstituted amides of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid, which are active as antiinflammatory, analgesic, antipyretic, antisecretive and antitussive agents, are disclosed.These amides are prepared by reacting an amine with an activated derivative of the 1-methyl-5-p-toluoylpyrrole-2-acetic-acid of formula ##STR1## where X is an activating group suitable for promoting the formation of an amide bond.

    Abstract translation: 公开了1-甲基-5-对甲苯酰基吡咯-2-乙酸的N-单取代和N，N-二取代的酰胺，其作为抗炎，镇痛，解热，抗分解和止咳剂是有活性的。 这些酰胺通过使胺与式（IMAGE）的1-甲基-5-对甲苯酰基吡咯-2-乙酸的活化衍生物反应来制备，其中X是适于促进形成酰胺键的活化基团。

    Bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane
    99.
    发明授权
    Bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane 失效
    双[4-（3,4-二甲基甲酰吡咯烷基）苯基]甲烷

    公开(公告)号：US4851544A

    公开(公告)日：1989-07-25

    申请号：US221386

    申请日：1988-07-19

    Applicant: Raphael M. Ottenbrite

    Inventor： Raphael M. Ottenbrite

    IPC: C07D207/32 ,  C07D207/325 ,  C08G73/12

    CPC classification number: C07D207/325 ,  C08G73/12

    Abstract: A polyimide composition consisting essentially of recurring units having the following structural formula: ##STR1## is produced by the copolymerization of a bismaleimide and bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane.

    Abstract translation: 主要由具有以下结构式的重复单元组成的聚酰亚胺组合物：通过双马来酰亚胺和双[4-（3,4-二甲基甲酰吡咯烷基）苯基]甲烷的共聚合产生。

    Aryl pyrroles as useful antiallergy compounds
    100.
    发明授权
    Aryl pyrroles as useful antiallergy compounds 失效
    芳基吡咯酮作为有用的抗过敏化合物

    公开(公告)号：US4792568A

    公开(公告)日：1988-12-20

    申请号：US851989

    申请日：1986-04-14

    Applicant: Joseph Auerbach

    Inventor： Joseph Auerbach

    IPC: C07D207/32 ,  C07D207/333 ,  A61K31/40 ,  C07D207/325

    CPC classification number: C07D207/333

    Abstract: This invention relates to new lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties. The present new compounds are of the formula: ##STR1## and salts thereof; wherein, R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower aralkyl, phenyl, naphthyl, or a nitrogen oxygen or sulfur heterocyclic; andY.sub.1 and Y are independently hydrogen, lower alkyl, hydroxy, lower alkoxy, aryloxy, lower aralkoxy, aryl, lower aralkyl, carboxy, lower carbalkoxy, lower carbaralkoxy, carbaryloxy, formyl, or alkyl, alkenyl or alkynyl containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms;provided that when Y and Y.sub.1 are both hydrogen or when Y.sub.1 is hydrogen and Y is CHO, the R is other than hydrogen, unsubstituted phenyl, or lower alkyl.

    Abstract translation: 本发明涉及具有抗炎和抗过敏性质的新的脂氧合酶抑制剂。 本发明的新化合物具有以下结构式：其中： 其中R为氢，低级烷基，低级烯基，低级炔基，低级芳烷基，苯基，萘基或氮氧或硫杂环; 并且Y 1和Y独立地为氢，低级烷基，羟基，低级烷氧基，芳氧基，低级芳烷氧基，芳基，低级芳烷基，羧基，低级烷氧羰基，低级卡尔巴尔氧基，碳酰氧基，甲酰基或含有至多6个碳原子的烷基，烯基或炔基 在主链和总共10个碳原子; 条件是当Y和Y1都是氢或当Y1是氢且Y是CHO时，R不是氢，未取代的苯基或低级烷基。

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