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91.发明授权Modular implant system containing active substances and method for the production thereof 有权含有活性物质的模块化植入体系及其生产方法公开(公告)号：US08003121B1
公开(公告)日：2011-08-23
申请号：US10343363
申请日：2000-08-01
Applicant: Elvira Dingeldein , Helmut Wahlig , Jörg Bauer , Edgar Wüst , Christoph Sattig
Inventor： Elvira Dingeldein , Helmut Wahlig , Jörg Bauer , Edgar Wüst , Christoph Sattig
CPC classification number: A61L24/0015 , A61L24/06 , A61L2300/406 , A61L2300/416 , A61L2300/44 , C08L33/06
Abstract: System of implant components containing active agents, wherein each component is intended to function as an additive for an implant material produced with a powdery or finely granulated starting material and/or active agents and additives.Each component is powdery or finely granulated and includes at least one powdery or finely granulated active agent or additive having a higher dosage than the desired concentration for the application. The components themselves are made of a powdery or finely granulated starting material for the implant material, as well as of the active agent or additive. The active agents can be chemotherapeutical agents, such as antibiotics, whereas the additives can be x-ray contrast materials and/or or additives that alter the physical properties of the starting material, such as its elasticity or viscosity.
Abstract translation: 包含活性剂的植入物组分的系统，其中每个组分旨在作为用粉末状或精细粒化的原料和/或活性剂和添加剂生产的植入材料的添加剂。 每种组分是粉状或细粒化的，并且包括至少一种粉末状或细粒状的活性剂或添加剂，其用量高于所需应用浓度。 组分本身由用于植入材料以及活性剂或添加剂的粉末状或精细制粒的起始材料制成。 活性剂可以是化学治疗剂，例如抗生素，而添加剂可以是改变起始物质的物理性质的X射线对比材料和/或添加剂，例如其弹性或粘度。
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92.发明申请POST IRRADIATION SHELF-STABLE DUAL PASTE DIRECT INJECTABLE BONE CEMENT PRECURSOR SYSTEMS AND METHODS OF MAKING SAME 有权后喷射保护性双稳态直接注射骨水泥前体系统及其制造方法
公开(公告)号：US20110152195A1
公开(公告)日：2011-06-23
申请号：US12970393
申请日：2010-12-16
Applicant: Donal O'Mahony , Venkat R. Garigapati , Adrian Sun Wai , Brian Hess , Matthew E. Murphy
Inventor： Donal O'Mahony , Venkat R. Garigapati , Adrian Sun Wai , Brian Hess , Matthew E. Murphy
CPC classification number: A61L24/06 , A61L24/001 , A61L24/02 , A61L27/12 , A61L27/50 , A61L2430/02
Abstract: The present invention relates to a bone cement precursor system that is presented in the form of two shelf-stable pastes which have been terminally sterilized and are held in separate containers during product transport and storage. When the product is used during surgery, these pastes inject to a site of application through a static mixing device by the action of applied injection force. When the two pastes are mixed, they start to react to each other while injecting out. The resulting composition is highly biocompatible, osteoconductive, injectable, rapid setting and bioresorbable, and is useful in connection with bone repair procedures, for example, in the craniomaxillofacial, trauma and orthopedic areas.
Abstract translation: 本发明涉及一种骨水泥前体体系，其以两种储存稳定的糊状物的形式存在，这些浆料已被终止灭菌，并在产品运输和储存期间保持在分开的容器中。 当在手术中使用该产品时，这些糊剂通过施加注射力的作用通过静态混合装置注射到施用部位。 当两种糊料混合时，它们在注射时开始彼此反应。 所得组合物具有高生物相容性，骨诱导性，可注射，快速凝固和生物可再吸收，并且可用于骨修复程序，例如颅颌面，创伤和矫形区域。
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公开(公告)号：US20110144231A1
公开(公告)日：2011-06-16
申请号：US13000691
申请日：2009-06-30
Applicant: Juergen Engelbrecht , Ademola Olaseni Akinmade
Inventor： Juergen Engelbrecht , Ademola Olaseni Akinmade
CPC classification number: A61K6/0835 , A61K6/0023 , A61L24/06 , C08L29/04 , C08L67/02 , C08L33/00
Abstract: The invention relates to a polyalkenoate cement for biomedical or dental applications, comprising: a) at least one acidic, phosphorus-based polyalkenoate polymer, b) at least one acid-soluble salt or acid-soluble compound of a multivalent metal, c) at least one non-polymeric acidic phosphorus compound and d) an ion-releasing, finely divided glass which is capable of reacting with components (a), (b) and (c) in the presence of water.
Abstract translation: 本发明涉及用于生物医学或牙科应用的聚烯丙酯粘合剂，其包含：a）至少一种酸性，磷基聚烯烃酸酯聚合物，b）至少一种酸可溶性盐或多价金属的酸溶性化合物，c） 至少一种非聚合酸性磷化合物和d）能够在水存在下与组分（a），（b）和（c）反应的离子释放的细碎玻璃。
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公开(公告)号：US20110118363A1
公开(公告)日：2011-05-19
申请号：US12900603
申请日：2010-10-08
Applicant: Jarl Jensen , Ravi Ramjit , Ta Kang Keng
Inventor： Jarl Jensen , Ravi Ramjit , Ta Kang Keng
IPC: C09J191/00 , A61K47/32 , A61P17/02
CPC classification number: A61L24/06 , A61F5/445 , A61L15/30 , A61L15/34 , A61L15/58 , A61L24/0015 , A61L24/0031 , A61L24/043 , A61L2400/14
Abstract: The present invention relates to an adhesive composition applicable to skin comprising: (i) a polar oil or fat including (a) at least one triglyceride and/or (b) at least one fatty acid of the formula R—CO2H, wherein R is a C3 to C30 alkyl group; and (ii) at least one homopolymer, and/or copolymer. This invention also relates to a medical adhesive device including such adhesive composition.
Abstract translation: 本发明涉及适用于皮肤的粘合剂组合物，其包含：（i）极性油或脂肪，其包含（a）至少一种甘油三酯和/或（b）至少一种式R-CO 2 H的脂肪酸，其中R为 C3至C30烷基; 和（ii）至少一种均聚物和/或共聚物。 本发明还涉及包括这种粘合剂组合物的医用粘合剂装置。
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公开(公告)号：US20100272649A1
公开(公告)日：2010-10-28
申请号：US12750782
申请日：2010-03-31
Applicant: Berthold Nies , Werner Siol
Inventor： Berthold Nies , Werner Siol
CPC classification number: A61L24/06 , A61L2430/02 , Y10S977/904 , Y10S977/908 , C08L33/12
Abstract: A bioactive PMMA (polymethylmethacrylate) bone cement contains a powder component and a reactive monomer liquid, wherein the powder component and the reactive monomer liquid when mixed with one another react with one another and form a polymer-based solid material. The powder component contains particulate polymer powder of polymethylmethacrylates; a radical starter; and anionic copolymer nanoparticles. The anionic copolymer nanoparticles are distributed in nano-particulate form within the particulate powder component or coated as a film on particles of the particulate polymer powder.
Abstract translation: 生物活性PMMA（聚甲基丙烯酸甲酯）骨水泥含有粉末成分和反应性单体液体，其中当彼此混合时，粉末组分和反应性单体液体彼此反应并形成基于聚合物的固体材料。 粉末成分含有聚甲基丙烯酸甲酯的微粒聚合物粉末; 激进的启动者 和阴离子共聚物纳米粒子。 阴离子共聚物纳米颗粒以纳米颗粒形式分布在颗粒状粉末组分内，或者作为薄膜涂覆在颗粒状聚合物粉末颗粒上。
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公开(公告)号：US20100269749A1
公开(公告)日：2010-10-28
申请号：US12833036
申请日：2010-07-09
Applicant: Ibraheem T. Badejo , Teresa Warren
Inventor： Ibraheem T. Badejo , Teresa Warren
IPC: B05C5/00
Abstract: An adhesive composition is provided including one or more polymerizable cyanoacrylate monomers and boron trifluoride as a stabilizer or complexing agent. The adhesive composition may also include or be used with a decomplexing agent, particularly one or more quaternary ammonium fluoride salts or one or more quaternary ammonium ether salts. A polymerization initiator or accelerator may also be used. The viscosity of the adhesive composition may be controlled by addition of a thickening agent which may be a polymer or copolymer catalyzed by a boron trifluoride complex or compound. Methods for the application of the adhesive compositions to living tissue are also provided.
Abstract translation: 提供了包含一种或多种可聚合的氰基丙烯酸酯单体和三氟化硼作为稳定剂或络合剂的粘合剂组合物。 粘合剂组合物还可以包括或与解络剂一起使用，特别是一种或多种季铵氟化物盐或一种或多种季铵醚盐。 也可以使用聚合引发剂或促进剂。 粘合剂组合物的粘度可以通过加入增稠剂来控制，增稠剂可以是由三氟化硼配合物或化合物催化的聚合物或共聚物。 还提供了将粘合剂组合物施用于生物组织的方法。
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97.发明申请METHODS AND APPARATUS FOR REPLACING BIOLOGICAL JOINTS USING BONE CEMENT IN A SUSPENDED STATE 审中-公开在暂停状态下使用骨水泥替代生物接头的方法和装置
公开(公告)号：US20100125335A1
公开(公告)日：2010-05-20
申请号：US12544697
申请日：2009-08-20
Applicant: Robert J. Daley
Inventor： Robert J. Daley
Abstract: The present disclosure provides methods and apparatus for replacing biological joints, but applies also to the fixation of any solid implant for use in dental or orthopaedic applications. In general, an ideal amount of bone cement is applied to the implant prior to going in to the operating room. Next, the polymerization (e.g., drying) process is suspended with a coating and/or a chemical. Once the implant(s) are needed in the operating room, the polymerization process is resumed. In this manner, the bone cement does not need to be mixed in the operating room, the surgeon does not need to “race the clock,” each implant is placed with the ideal amount of cement in the ideal consistency, there are no powder clumps, and there is little to no excess cement to remove.
Abstract translation: 本公开提供了用于替换生物关节的方法和装置，但也适用于用于牙科或矫形应用的任何固体植入物的固定。 通常，在进入手术室之前，将植入物施加理想量的骨水泥。 接下来，用涂层和/或化学品悬浮聚合（例如干燥）过程。 一旦在手术室中需要植入物，则恢复聚合过程。 以这种方式，骨水泥不需要在手术室中混合，外科医生不需要“跑步”，每个植入物以理想的一致性放置理想量的水泥，没有粉末团块 ，几乎没有多余的水泥去除。
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公开(公告)号：US20100090157A1
公开(公告)日：2010-04-15
申请号：US12520703
申请日：2007-12-17
Applicant: Prabhakara S. Rao , Steven M. Aasen , Ahmed S. Abuelyaman , Sumita B. Mitra , Bradley D. Craig , Brian A. Shukla , David J. Plaut , Victoria A. Russell
Inventor： Prabhakara S. Rao , Steven M. Aasen , Ahmed S. Abuelyaman , Sumita B. Mitra , Bradley D. Craig , Brian A. Shukla , David J. Plaut , Victoria A. Russell
IPC: C09K13/00
CPC classification number: C09J201/005 , A61K6/0023 , A61L24/06 , C08F2/32 , C09J133/14 , C08L25/04 , C08L33/06
Abstract: An adhesive composition including an etchant for a hard tissue surface, at least one multifunctional crosslinkable (meth)acrylate monomer with a functionality greater than 4, and water. The adhesive composition is a water-in-oil emulsion.
Abstract translation: 包括硬组织表面的蚀刻剂，功能大于4的至少一种多官能交联性（甲基）丙烯酸酯单体和水的粘合剂组合物。 粘合剂组合物是油包水乳液。
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99.发明授权
公开(公告)号：US07687053B2
公开(公告)日：2010-03-30
申请号：US09933316
申请日：2001-08-20
Applicant: Stephen C. Porter
Inventor： Stephen C. Porter
IPC: A61K49/04
CPC classification number: C08F20/32 , A61L24/06 , A61L2430/36 , C08L35/04
Abstract: Compositions for embolization are disclosed herein. The compositions disclosed can have a matrix-forming component, a solid-aggregate material, and a rheology modifying agent, wherein the matrix-forming component includes at least alkyl cyanoacrylate monomers, a stabilizer, and a plasticizer, and the solid-aggregate material includes at least a radiopacifier. The composition and a method of administering the composition are useful for treating vasculature abnormalities, particularly when the composition solidifies upon contact with an ionic environment, such as blood.
Abstract translation: 本文公开了用于栓塞的组合物。 所公开的组合物可以具有基质形成组分，固体骨料材料和流变改性剂，其中基质形成组分至少包括氰基丙烯酸烷基酯单体，稳定剂和增塑剂，并且所述固体骨料材料包括 至少一个无线电传感器。 组合物和施用组合物的方法可用于治疗脉管系统异常，特别是当组合物在与离子环境例如血液接触时固化。
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公开(公告)号：US20100016467A1
公开(公告)日：2010-01-21
申请号：US12395527
申请日：2009-02-27
Applicant: Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
Inventor： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC: C08L33/12
CPC classification number: A61L24/06 , A61B17/8805 , A61B17/8822 , A61B17/8833 , A61B2017/00022 , A61L24/0084 , A61L24/02 , A61L24/043 , A61L27/16 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
Abstract: The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.
Abstract translation: 本公开内容涉及具有用于椎体成形术程序和其它骨成形术程序的延长工作时间的骨水泥制剂以及水泥注射器，其包括用于按需控制水泥粘度和流动参数的能量输送系统。 骨水泥制剂可以包括具有至少一种单体和包含聚合物颗粒和过氧化苯甲酰（BPO））的非液体组分的液体组分。 非液体组分可以进一步构造成允许BPO受控地暴露于液体单体，以便能够控制骨水泥组合物的粘度。
