公开(公告)号：US07923445B2

公开(公告)日：2011-04-12

申请号：US11897669

申请日：2007-08-31

Applicant: Stephen Roth ,  Clayton Buck ,  Christopher Self ,  Gary Olson

Inventor： Stephen Roth ,  Clayton Buck ,  Christopher Self ,  Gary Olson

IPC: A01K31/54 ,  A01K31/497

CPC classification number: C07D279/26 ,  C07D279/28 ,  C07D417/06 ,  C07D417/12 ,  C09B21/00

Abstract: The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.

Abstract translation: 本发明涉及抑制增殖并诱导活化的淋巴细胞（包括T细胞和B细胞）的细胞凋亡。 本发明还提供了用于抑制增殖和诱导活化淋巴细胞凋亡的组合物和方法，以及通过施用5-HT受体拮抗剂治疗与活化淋巴细胞相关的疾病的方法。